Tangles of Ependyma-Choroid Plexus Contain B-Amyloid Protein Epitopes and Represent a New Form of Amyloid Fiber

Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern

“…4c), as shown by other authors [20,26,49]. The reaction was not congruent with the intracellular age-related Congo red-staining protein fibrils and Biondi rings, which seem to consist of a special type of intracellular amyloid [8,9] with Aβ features [42,58]. Corresponding to this a weak cytoplasmic anti-Aβ reactivity was seen in 6 of our cases (5/9 being of the AA and 1/8 of the AL class).…”

Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern

“…4c), as shown by other authors [20,26,49]. The reaction was not congruent with the intracellular age-related Congo red-staining protein fibrils and Biondi rings, which seem to consist of a special type of intracellular amyloid [8,9] with Aβ features [42,58]. Corresponding to this a weak cytoplasmic anti-Aβ reactivity was seen in 6 of our cases (5/9 being of the AA and 1/8 of the AL class).…”

Choroid plexus: Target for polypeptides and site of their synthesis

“…Unlike apoJ, apoE promotes amyloid fibrillogenesis (Ma et al, 1994), and the apoE-sA␤ complexes do not easily dissociate (Strittmatter et al, 1993). This may explain the observations of amyloid deposition in choroidal epithelium (Miklossy et al, 1999;Wen et al, 1988).…”

Non‐Neoplastic Lesions of the Ependyma: A Neuropathological Overview

“…These inclusions are rarely also found in choroid plexus papilloma [82]. Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79].…”

“…Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79]. Miklossy et al [79] demonstrated that their occurrence was significantly associated with that of Alzheimer-type changes in the cerebral cortex and suggested that these ependymal or choroid plexus lesions might be the earliest manifestation of the degenerative process in Alzheimer disease.…”

“…It has long been known that, in elderly people, thread-or tanglelike cytoplasmic inclusions that are argyrophilic, periodic acid-Schiff-reactive, and positive for Congo red or thioflavin T appear frequently in choroid plexus epithelial cells and ependymal cells [78,79]. They are called "curly fibers" [79] or "Biondi body (or Biondi ring)" [78,80,81], and considered to represent a kind of senescent changes. These inclusions are rarely also found in choroid plexus papilloma [82].…”

Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern

“…4c), as shown by other authors [20,26,49]. The reaction was not congruent with the intracellular age-related Congo red-staining protein fibrils and Biondi rings, which seem to consist of a special type of intracellular amyloid [8,9] with Aβ features [42,58]. Corresponding to this a weak cytoplasmic anti-Aβ reactivity was seen in 6 of our cases (5/9 being of the AA and 1/8 of the AL class).…”

Choroid plexus: Target for polypeptides and site of their synthesis

“…Unlike apoJ, apoE promotes amyloid fibrillogenesis (Ma et al, 1994), and the apoE-sA␤ complexes do not easily dissociate (Strittmatter et al, 1993). This may explain the observations of amyloid deposition in choroidal epithelium (Miklossy et al, 1999;Wen et al, 1988).…”

Non‐Neoplastic Lesions of the Ependyma: A Neuropathological Overview

“…These inclusions are rarely also found in choroid plexus papilloma [82]. Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79].…”

“…Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79]. Miklossy et al [79] demonstrated that their occurrence was significantly associated with that of Alzheimer-type changes in the cerebral cortex and suggested that these ependymal or choroid plexus lesions might be the earliest manifestation of the degenerative process in Alzheimer disease.…”

“…It has long been known that, in elderly people, thread-or tanglelike cytoplasmic inclusions that are argyrophilic, periodic acid-Schiff-reactive, and positive for Congo red or thioflavin T appear frequently in choroid plexus epithelial cells and ependymal cells [78,79]. They are called "curly fibers" [79] or "Biondi body (or Biondi ring)" [78,80,81], and considered to represent a kind of senescent changes. These inclusions are rarely also found in choroid plexus papilloma [82].…”

Cerebrovascular involvement in systemic AA and AL amyloidosis: a clear haematogenic pattern

“…4c), as shown by other authors [20,26,49]. The reaction was not congruent with the intracellular age-related Congo red-staining protein fibrils and Biondi rings, which seem to consist of a special type of intracellular amyloid [8,9] with Aβ features [42,58]. Corresponding to this a weak cytoplasmic anti-Aβ reactivity was seen in 6 of our cases (5/9 being of the AA and 1/8 of the AL class).…”

Choroid plexus: Target for polypeptides and site of their synthesis

“…Unlike apoJ, apoE promotes amyloid fibrillogenesis (Ma et al, 1994), and the apoE-sA␤ complexes do not easily dissociate (Strittmatter et al, 1993). This may explain the observations of amyloid deposition in choroidal epithelium (Miklossy et al, 1999;Wen et al, 1988).…”

Non‐Neoplastic Lesions of the Ependyma: A Neuropathological Overview

“…These inclusions are rarely also found in choroid plexus papilloma [82]. Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79].…”

“…Their ultrastructure is unique and consists of fibrillary or tubular structures admixed with small lipid droplets [78,82,83] (Figure 5). These inclusions are immunoreactive for β-amyloid [78], tau protein [79], and ubiquitin [79]. Miklossy et al [79] demonstrated that their occurrence was significantly associated with that of Alzheimer-type changes in the cerebral cortex and suggested that these ependymal or choroid plexus lesions might be the earliest manifestation of the degenerative process in Alzheimer disease.…”

“…It has long been known that, in elderly people, thread-or tanglelike cytoplasmic inclusions that are argyrophilic, periodic acid-Schiff-reactive, and positive for Congo red or thioflavin T appear frequently in choroid plexus epithelial cells and ependymal cells [78,79]. They are called "curly fibers" [79] or "Biondi body (or Biondi ring)" [78,80,81], and considered to represent a kind of senescent changes. These inclusions are rarely also found in choroid plexus papilloma [82].…”