Tangeretin sensitises human lung cancer cells to TRAILinduced apoptosis via ROS-JNK/ERK-CHOP pathwaymediated up-regulation of death receptor 5

Liu, Xi; Chen, Lei; Liu, Yang; Zhang, Tao

doi:10.4314/tjpr.v16i1.4

Cited by 9 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, tangertin in combination with TRIAL in H1299 and H1975 cells downregulated anti-apoptotic Bcl-2, Bcl-xL, survivin, x-IAP, c-IAP1, and c-IAP2 and elevated expression of pro-apoptotic Bax and caspases-3, -8, and -9. In addition to a significant increase in expression of DR 4 and 5, induction of ER stress was mediated via upregulation of CHOP and elevation of ROS [161].…”

Section: Phytochemicalsmentioning

confidence: 99%

Flavonoids in Cancer and Apoptosis

Abotaleb

Samuel

Varghese

et al. 2018

Cancers

541

394

View full text Add to dashboard Cite

Cancer is the second leading cause of death globally. Although, there are many different approaches to cancer treatment, they are often painful due to adverse side effects and are sometimes ineffective due to increasing resistance to classical anti-cancer drugs or radiation therapy. Targeting delayed/inhibited apoptosis is a major approach in cancer treatment and a highly active area of research. Plant derived natural compounds are of major interest due to their high bioavailability, safety, minimal side effects and, most importantly, cost effectiveness. Flavonoids have gained importance as anti-cancer agents and have shown great potential as cytotoxic anti-cancer agents promoting apoptosis in cancer cells. In this review, a summary of flavonoids and their effectiveness in cancer treatment targeting apoptosis has been discussed.

show abstract

Section: Phytochemicalsmentioning

confidence: 99%

Flavonoids in Cancer and Apoptosis

Abotaleb

Samuel

Varghese

et al. 2018

Cancers

541

394

View full text Add to dashboard Cite

show abstract

“…As mentioned before, miRNA could bind to 3'-UTR of target mRNA to induce translational repression. There are target regions called "seed regions", which refer to the 7 nucleotides at 2 to 8 at the 5′ end of miRNA [12]. The "seed region" is the key sequence to recognize the target of miRNAs [12].…”

Section: Discussionmentioning

confidence: 99%

“…There are target regions called "seed regions", which refer to the 7 nucleotides at 2 to 8 at the 5′ end of miRNA [12]. The "seed region" is the key sequence to recognize the target of miRNAs [12]. The prediction results in this study from TargetScan indicated that there was a complementary sequence between 3'-UTR of CAMKK2 and 2 to 8 at the 5′ end of miR-378a-5p in compliance with Watson-Crick match [24], suggesting that calmodulin-dependent protein kinase kinase-2 was the direct target of miR-378a-5p.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

miR-378a-5p regulates CAMKK2/AMPK pathway to contribute to cerebral ischemia/reperfusion injury-induced neuronal apoptosis

Zhang

Deng

2021

Folia Histochem Cytobiol.

View full text Add to dashboard Cite

show abstract

“…Small noncoding microRNAs (miRNAs) have inhibitory effects on protein translation by directly targeting the 3′-untranslated region (3′-UTR) of mRNAs [4]. Many studies revealed that miRNAs were involved in the regulation of innate and adaptive immune responses [4]. For example, 66 aberrant miRNAs were identified using miRNA microarray chip analysis of renal biopsies of LN patients [5].…”

Section: Introductionmentioning

confidence: 99%

MiR-384 is associated with renal damage in lupus nephritis via regulation of TET3 expression

Zhang¹,

Lu²,

Ding³

et al. 2021

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To investigate the correlations between miR-384 expression and renal damage in lupus nephritis (LN).Methods: Lupus nephritis and normal tissues were collected during surgery. The relative miR-384 expression was evaluated by extracting RNA and performing quantitative real time PCR (qRT-PCR) assays. Expression of ten-eleven translocation (TET3) mRNA and protein were measured by qRT-PCR and western blotting, respectively. The 24-h urine protein, serum complement C3, and serum creatinine were determined using commercial enzyme-linked immunosorbent assay (ELISA) kits. TargetScan and luciferase assays were used to validate the binding site for miR-384 and its target mRNA. Relationships among miR-384, TET3, and renal damage were analyzed by Spearman rank-order correlation coefficients.Results: MiR-384 expression increased in LN tissues and was positively correlated with the activity index (AI) and chronicity index of LN, whereas miR-384 expression and serum complement C3 were negatively correlated. Positive correlations were observed between miR-384 expression and 24-h urine protein, serum creatinine, and systemic lupus erythematosus disease AI. TargetScan and luciferaseassays indicated that the TET3 3′-UTR was the direct target of miR-384. MiR-384 upregulation inhibited TET3 mRNA and protein expression, and was negatively associated with renal damage in LN.Conclusion: MiR-384 upregulation contributes to renal damage in LN by targeting the 3′-UTR of TET3 mRNA, suggesting that miR-384 is a potential biomarker and therapeutic target in LN. Keywords: MiR-384, Renal damage, Lupus nephritis, Ten-eleven translocation, TET3

show abstract

Tangeretin sensitises human lung cancer cells to TRAILinduced apoptosis via ROS-JNK/ERK-CHOP pathwaymediated up-regulation of death receptor 5

Cited by 9 publications

References 27 publications

Flavonoids in Cancer and Apoptosis

Flavonoids in Cancer and Apoptosis

miR-378a-5p regulates CAMKK2/AMPK pathway to contribute to cerebral ischemia/reperfusion injury-induced neuronal apoptosis

MiR-384 is associated with renal damage in lupus nephritis via regulation of TET3 expression

Contact Info

Product

Resources

About