Take a Deep Breath - Monitoring of Inhaled Nanoparticles with Magnetic Particle Imaging

Wegner, Franz; Buzug, Thorsten M.; Barkhausen, Joerg

doi:10.7150/thno.27454

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…159 When taken with the results from Zhou et al, 27 the authors demonstrated a proof-of-concept for MPI-based perfusion-ventilation mapping. 341 This mapping has been applied clinically using other modalities, for the diagnosis of PE and in preoperative evaluation of the lungs. The rate of cancer curing almost directly correlates with the stage at which it is diagnosed, meaning that if it was diagnosed and provided with appropriate treatment at an earlier stage, the cure rate would increase significantly.…”

Section: Perfusion Imagingmentioning

confidence: 99%

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Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

2022

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Section: Perfusion Imagingmentioning

confidence: 99%

“…158 When taken with the results from Zhou et al , 27 the authors demonstrated a proof-of-concept for MPI-based perfusion–ventilation mapping. 340 This mapping has been applied clinically using other modalities, for the diagnosis of PE and in preoperative evaluation of the lungs.…”

Section: Primary Biomedical Applications Of Mpimentioning

confidence: 99%

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

2022

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“…Magnetic particle imaging (MPI) is an emerging tomographic method that uses superparamagnetic iron oxide nanoparticles (SPIONs) as imaging agents 12 - 14 . Since its first introduction in 2005 15 , high mass sensitivity (Fe nanograms), high spatial resolution (sub-mm), zero tissue depth signal attenuation, and lack of ionizing radiation have been reported as advantages of MPI 16 .…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles

et al. 2021

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Inflammation is a pivotal driver of atherosclerotic plaque progression and rupture and is a target for identifying vulnerable plaques. However, challenges arise with the current in vivo imaging modalities for differentiating vulnerable atherosclerotic plaques from stable plaques due to their low specificity and sensitivity. Herein, we aimed to develop a novel multimodal imaging platform that specifically targets and identifies high-risk plaques in vivo by detecting active myeloperoxidase (MPO), a potential inflammatory marker of vulnerable atherosclerotic plaque. Methods: A novel multimodal imaging agent, 5-HT-Fe 3 O 4 -Cy7 nanoparticles (5HFeC NPs), used for active MPO targeting, was designed by conjugating superparamagnetic iron oxide nanoparticles (SPIONs) with 5-hydroxytryptamine and cyanine 7 N-hydroxysuccinimide ester. The specificity and sensitivity of 5HFeC NPs were evaluated using magnetic particle imaging (MPI), fluorescence imaging (FLI), and computed tomographic angiography (CTA) in an ApoE -/- atherosclerosis mouse model. Treatment with 4-ABAH, an MPO inhibitor, was used to assess the monitoring ability of 5HFeC NPs. Results: 5HFeC NPs can sensitively differentiate and accurately localize vulnerable atherosclerotic plaques in ApoE -/- mice via MPI/FLI/CTA. High MPI and FLI signals were observed in atherosclerotic plaques within the abdominal aorta, which were histologically confirmed by multiple high-risk features of macrophage infiltration, neovascularization, and microcalcification. Inhibition of active MPO reduced accumulation of 5HFeC NPs in the abdominal aorta. Accumulation of 5HFeC NPs in plaques enabled quantitative evaluation of the severity of inflammation and monitoring of MPO activity. Conclusions: This multimodal MPI approach revealed that active MPO-targeted nanoparticles might serve as a method for detecting vulnerable atherosclerotic plaques and monitoring MPO activity.

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“…MPI does not use ionizing radiation and SPIO tracers have a long shelf life ex vivo, while they break down in vivo, with iron being incorporated into hemoglobin and ferritin. [14][15] In addition, images obtained from MPI can be coregistered with other modalities, like computed-tomography (CT) and MR. Proof-of-principle studies have explored the application of MPI for blood pool imaging, [16][17][18][19][20] lung perfusion, [21][22][23] bleed detection, [24][25] and tracking of nanoparticle accumulation in cancer tumors. [26][27] .…”

Section: Introductionmentioning

confidence: 99%

Tracking Adoptive T Cell Therapy Using Magnetic Particle Imaging

Rivera‐Rodriguez

Hoang-Minh

Chiu‐Lam

et al. 2020

Preprint

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Adoptive cellular therapy (ACT) is a potent strategy to boost the immune response against cancer. ACT is an effective treatment for blood cancers, such as leukemias and lymphomas, but faces challenges treating solid tumors and cancers in locations like the brain. A critical step for success of ACT immunotherapy is achieving efficient trafficking of T cells to solid tumors, and the non-invasive and quantitative tracking of adoptively transferred T cell biodistribution would accelerate its development.Here, we demonstrate the use of Magnetic Particle Imaging (MPI) to non-invasively track ACT T cells in vivo. Labeling T cells with the superparamagnetic iron oxide nanoparticle tracer ferucarbotran did not affect T cell viability, phenotype, or cytotoxic function in vitro. Following ACT, ferucarbotran-labeled T cells were detected and quantified using MPI ex vivo and in vivo, in a mouse model of invasive brain cancer. Proof-of-principle in vivo MPI demonstrated its capacity to detect labeled T cells in lungs and liver after intravenous administration and to monitor T cell localization in the brain after intraventricular administration. Ex vivo imaging using MPI and optical imaging suggests accumulation of systemically administered ferucarbotran-labeled T cells in the brain, where MPI signal from ferucarbotran tracers and fluorescently tagged T cells were observed. Ex vivo imaging also suggest differential accumulation of nanoparticles and viable T cells in other organs like the spleen and liver. These results support the use of MPI to track adoptively transferred T cells and accelerate the development of ACT treatments for brain tumors and other cancers. METHODSAnimals and cell lines: C57BL/6 wild type mice were obtained from Jackson Laboratory. Transgenic pmel specific DsRed C57BL/6 mice were obtained from breeding a DsRed transgenic mouse (B6.Cg-Tg(CAG-DsRed*MST)1Nagy/J) and a pmel transgenic mouse (B6.Cg-Thy1a/Cy Tg(TcraTcrb)8Rest/J) to obtain the DsRed pmel-specific mouse colony. The pmel-specific T cell receptor of these mice recognizes the gp100 antigen expressed by the studied murine glioblastoma cell line, and the DsRed fluorescence allows ex vivo identification of transferred T cells. The murine glioblastoma cell line KR158B-Luc was a kind gift from Tyler Jacks. 30

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Take a Deep Breath - Monitoring of Inhaled Nanoparticles with Magnetic Particle Imaging

Cited by 7 publications

References 21 publications

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

Magnetic particle imaging: tracer development and the biomedical applications of a radiation-free, sensitive, and quantitative imaging modality

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles

Tracking Adoptive T Cell Therapy Using Magnetic Particle Imaging

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