Tailored doxycycline delivery from MCM-41-type silica carriers

Deaconu, Mihaela; Nicu, Ioana; Tincu, Robert; Brezoiu, Ana-Maria; Mitran, Raul−Augustin; Vasile, Eugeniu; Matei, Cristian; Berger, Daniela

doi:10.1007/s11696-018-0457-z

Cited by 27 publications

(18 citation statements)

References 50 publications

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“…For the DOX-30CaP@MSi powders, the high burst release of DOX is observed most probably due to weak interaction between DOX and silica surface. Similar observations for DOX-loaded MSi were noticed by Deacuno et al [41] who declared, that initial burst release of DOX has been strongly associated with the type of functional groups presented on MSi surface. Ide et al [42] claimed that the calcination process of MSi results with the low concentration of surface silanol groups.…”

Section: Dox Adsorption Onto the 30cap@msisupporting

confidence: 87%

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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We reported the new biphasic composites of calcium phosphate and mesoporous silica material (CaP@MSi) in the form of powders and pellets as a potential bone drug delivery system for doxycycline hydrochloride (DOX). The CaP@MSi powders were synthesized by cationic surfactant-templating method. The effects of 10, 20, and 30% CaP content in the CaP@MSi powders on the molecular surface structure, the cytotoxicity against osteoblast cells in vitro, and the mineralization potential in simulated body fluid were investigated. The CaP@MSi characterized by the highest mineralization potential (30% CaP content) were used for DOX adsorption and pelletization process. The CaP which precipitated in the CaP@MSi composites was characterized as calcium-deficient with the Ca:P molar ratio between 1.0 and 1.2. The cytotoxicity assays demonstrated that the CaP content in MSi increases osteoblasts viability indicating the CaP@MSi (30% CaP content) as the most biocompatible. The combination of CaP and MSi was an effective strategy to improve the mineralization potential of parent material. Upon immersion in simulated body fluid, the CaP of composite converted into the bone-like apatite. The obtained pellets preserved the mineralization potential of CaP@MSi and provided the prolonged 5-day DOX release. The obtained biphasic CaP@MSi composites seem to have an application potential as bone-specific drug delivery system.

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Section: Dox Adsorption Onto the 30cap@msisupporting

confidence: 87%

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Prokopowicz

Szewczyk

Skwira

et al. 2019

Drug Deliv. and Transl. Res.

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“…The mercaptopropyl-functionalized silica material, MCM-SH, was prepared by post-synthesis method using commercial MCM-41 and (3-mercaptopropyl) triethoxysilane (MPTES) in toluene at reflux, 4 h, using toluene:silica:organosilane molar ratio of 230:5:1. MCM-SO 3 H material was obtained from MCM-SH sample through oxidation of thiol groups to sulfonic moieties, at room temperature, using H 2 O 2 acidic aqueous solution [ 51 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Nanoconfinement of Polyphenolic Extract from Grape Pomace into Functionalized Mesoporous Silica on Its Biocompatibility and Radical Scavenging Activity

et al. 2020

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The aim of this paper is to assess the properties of Mamaia (MM) grape pomace polyphenolic extract loaded onto pristine and functionalized MCM-41 mesoporous silica as potential ingredients for nutraceuticals or cosmetics. The chemical profile of hydroalcoholic polyphenolic extracts, prepared either by conventional extraction or microwave-assisted method, was analyzed by reverse-phase high-performance liquid chromatography with photodiode array detector (HPLC-PDA) analysis, while their radical scavenger activity (RSA) was evaluated using DPPH (2,2-diphenyl-1-picrylhydrazyl radical) and ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) assays. The extract-loaded materials were characterized by Fourier transform infrared (FTIR) spectroscopy, N2 adsorption-desorption isotherms, thermogravimetric analysis, as well as RSA (DPPH and ABTS assays). The polyphenols release profiles from pristine and functionalized (with mercaptopropyl, propyl sulfonic acid, cyanoethyl and propionic acid moieties) MCM-41-type supports were determined in phosphate buffer solution (PBS) pH 5.7. For selected materials containing embedded phytochemicals, cellular viability, and oxidative stress level on immortalized mouse embryonic fibroblast cell line (NIH3T3) were evaluated. A more acidic functional groups linked on silica pore walls determined a higher amount of phytochemicals released in PBS. The extract-loaded materials showed a good cytocompatibility on tested concentrations. The embedded extract preserved better the RSA over time than the free extract. The polyphenols-loaded MCM-41-type silica materials, especially MM@MCM-COOH material, demonstrated a good in vitro antioxidant effect on NIH3T3 cells, being potential candidates for nutraceutical or cosmetic formulations.

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“…Other studies reported the use of hydrophobic antimicrobials drugs-loaded MSNs to enhance their effect in biological media (112,113,118). On the other hand, for hydrophilic antimicrobial drugs which are very soluble in an aqueous/biological environments, MSNs can also promote a controlled drug release (116).…”

Section: Bacterial Infectionsmentioning

confidence: 99%

“…Aiming to overcome the aforementioned drawback and considering the development of bacterial resistance, Deaconu et al . ( 116 ) proposed to ally antibiotic properties and MSNs matrix by preparing DOXY-loaded MCM-41-type MSNs and modified MSNs to treat Klebsiella pneumoniae strains. MCM-41 (using hexadecyltrimethylammonium bromide (C 16 TAB) and TMOS as surfactant and inorganic precursor, respectively) platforms were prepared and then modified with phenyl, mercaptopropyl, propylsulfonic and magnesium labeled (MCM-C 6 H 5 , MCM-SH, MCM-SO 3 H and MCM-Mg, respectively).…”

Section: Msns For Infectious Diseases Treatmentmentioning

confidence: 99%

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

et al. 2020

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Infectious diseases are a major global concern being responsible for high morbidity and mortality mainly due to the development and enhancement of multidrug-resistant microorganisms exposing the fragility of medicines and vaccines commonly used to these treatments. Taking into account the scarcity of effective formulation to treat infectious diseases, nanotechnology offers a vast possibility of groundbreaking platforms to design new treatment through smart nanostructures for drug delivery purposes. Among the available nanosystems, mesoporous silica nanoparticles (MSNs) stand out due their multifunctionality, biocompatibility and tunable properties make them emerging and actual nanocarriers for specific and controlled drug release. Considering the high demand for diseases prevention and treatment, this review exploits the MSNs fabrication and their behavior in biological media besides highlighting the most of strategies to explore the wide MSNs functionality as engineered, smart and effective controlled drug release nanovehicles for infectious diseases treatment.

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Tailored doxycycline delivery from MCM-41-type silica carriers

Cited by 27 publications

References 50 publications

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Biphasic composite of calcium phosphate-based mesoporous silica as a novel bone drug delivery system

Effect of Nanoconfinement of Polyphenolic Extract from Grape Pomace into Functionalized Mesoporous Silica on Its Biocompatibility and Radical Scavenging Activity

Highlights in Mesoporous Silica Nanoparticles as a Multifunctional Controlled Drug Delivery Nanoplatform for Infectious Diseases Treatment

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