Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population

Ma, Xiang; Huang, Chih Chia; Luo, Dakui; Wang, Younan; Tang, Ran; Huan, Xiangkun; Zhu, Yaping; Xu, Zekuan; Liu, Ping; Yang, Li

doi:10.18632/oncotarget.13513

Cited by 14 publications

(18 citation statements)

References 39 publications

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“…Although TINCR is strongly upregulated in GC and could promote cell growth,15,16 the specific mechanism that was involved in human GC progression still needed to be further studied.…”

Section: Discussionmentioning

confidence: 99%

The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

Chen¹,

Liu²,

Yang³

et al. 2017

OTT

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BackgroundAccumulating evidence indicates that the long noncoding RNA, TINCR, plays a critical role in cancer progression and metastasis. However, the overall biological role and mechanisms of TINCR that were involved in human gastric cancer (GC) progression remain largely unknown.MethodsTINCR expression was measured in 56 paired tumor and adjacent nontumor tissue samples by real-time polymerase chain reaction (PCR). Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were gained from bioinformatic analysis, luciferase assays. The effects of TINCR and miR-375 on GC cell apoptosis and proliferation were studied by RNA interference approaches in vitro and in vivo. The correlation of TINCR and PDK1 was identified by real-time PCR and Western blot analysis.ResultsOur results showed that miR-375 level decreased and TINCR level increased in tumor tissues. In addition, TINCR was a target of miR-375 and inhibited its expression in GC cells. Furthermore, the low expression of TINCR increased cell apoptosis and inhibited the proliferation of GC cells, while the downregulation of miR-375 reversed the function. In particular, TINCR could negatively regulate the miR-375 expression and increased the PDK1 expression in GC cells. Finally, tumor growth suppression was retarded with miR-375 downregulated in TINCR knockdown of GC cell xenografts.ConclusionThe long noncoding RNA TINCR functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in GC. The ceRNA regulatory network of TINCR/miR-375/PDK1 allows us to better understand the pathogenesis of GC and facilitate the development of long noncoding RNA (lncRNA)-directed diagnostics in GC.

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“…Although TINCR is strongly upregulated in GC and could promote cell growth,15,16 the specific mechanism that was involved in human GC progression still needed to be further studied.…”

Section: Discussionmentioning

confidence: 99%

The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

Chen¹,

Liu²,

Yang³

et al. 2017

OTT

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“…Very recently, studies have confirmed that the lncRNA TINCR gene, which regulates cell invasion and migration, is associated with susceptibility to various diseases. A study by Ma et al found that SNPs of the lncRNA TINCR were significantly associated with decreased gastric cancer susceptibility by decreasing its gene expression levels. Moreover, a study by Zheng et al found that lncRNA TINCR polymorphisms were associated with the progression of colorectal cancer, and SNP rs2288947 may be a biomarker with the occurrence and progression of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…[15][16][17][18] Recently, studies have found that genetic variation in TINCR was associated with a variety of diseases, such as the SNP rs2288947, which contributed to the susceptibility and progression of colorectal cancer and susceptibility to gastric cancer. 19,20 Furthermore, studies have found that some genes that regulate cell proliferation, invasion, and migration are associated with susceptibility to miscarriage; for example, H19 and p53 gene polymorphisms. 8,21 These studies suggest that TINCR gene polymorphisms may be associated with recurrent miscarriage.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, TINCR has been shown to regulate proliferation, migration, and invasion of multiple tumor cells . Recently, studies have found that genetic variation in TINCR was associated with a variety of diseases, such as the SNP rs2288947, which contributed to the susceptibility and progression of colorectal cancer and susceptibility to gastric cancer . Furthermore, studies have found that some genes that regulate cell proliferation, invasion, and migration are associated with susceptibility to miscarriage; for example, H19 and p53 gene polymorphisms .…”

Section: Introductionmentioning

confidence: 99%

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Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population

Huang¹,

Zhou

et al. 2019

Clinical Laboratory Analysis

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Studies have shown that many genes that regulate cell migration are associated with susceptibility to recurrent miscarriage. Terminal differentiation‐induced non‐coding RNA (TINCR) regulates the migration and invasion of a variety of tumor cells and is associated with susceptibility to various diseases. However, whether the lncRNA TINCR polymorphism is associated with susceptibility to recurrent miscarriage is unclear. Therefore, we investigated the relationship between the rs2288947 A > G polymorphism of the lncRNA TINCR and susceptibility to recurrent abortion. We recruited 248 recurrent spontaneous abortion patients and 392 healthy control subjects from the Southern Chinese population and used the TaqMan method for genotyping. There was no evidence that this polymorphism is associated with recurrent miscarriage (AG vs AA: adjusted OR = 0.904, 95% CI = 0.647‐1.264, P = 0.5552; GG and AA: adjusted OR = 0.871, 95% CI = 0.475‐1.597, P = 0.6542; dominant model: AG/GG vs AA: adjusted OR = 0.898, 95% CI = 0.653‐1.236, P = 0.5101; and recessive model: GG vs AA/AG: adjusted OR = 0.910, 95% CI = 0.505‐1.639, P = 0.7527). The stratified analysis also showed no significant associations. This study suggests that the rs2288947 A > G polymorphism of the lncRNA TINCR may not be associated with recurrent miscarriage in a Southern Chinese population. A larger multicenter study is needed to confirm our conclusions.

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“…We collected relevant information, such as age, gender, hypertension, diabetes, smoking history, drinking history, residence, family history of GC (FH), and clinical data from the medical history, or face-to-face interviews were conducted to supplement the above information. The definitions of hypertension and diabetes were described in the previous studies [ 5 , 6 ]. The smokers were defined as individuals who formerly or currently smoked ≥10 cigarettes per day no less than 2 years.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population

Jiang

et al. 2017

Disease Markers

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Long noncoding RNA (lncRNA) phosphatase and tensin homolog pseudogene 1 (PTENP1) is significantly downregulated in gastric cancer (GC), playing critical roles in GC progression. However, the association between PTENP1 genetic variants and GC risk has not yet been reported. Using TaqMan technology, three lncRNA PTENP1 tag single nucleotide polymorphisms (tagSNPs) (rs7853346 C>G, rs865005 C>T, and rs10971638 G>A) were genotyped in 768 GC patients and 768 cancer-free controls in a Chinese population. We found that subjects with rs7853346 G allele had a remarkably decreased risk of GC, compared with those carrying C allele (P = 0.011 in an additive model, P = 0.033 after Bonferroni's correction). The further stratified analyses showed that the link between variant genotypes of rs7853346 and decreased GC risk was more obvious in older subjects (≥60 years), nonsmokers, nondrinkers, and subjects without family history of GC. We also found that relative PTENP1 mRNA expression levels were higher in rs7853346 CG/GG genotype carriers than those with common genotype in both GC and normal tissues (P < 0.05). Besides, bioinformatics analyses revealed that rs7853346 may change the local folding structure and alter the target microRNAs (miRNAs) of PTENP1. In conclusion, our results suggested that lncRNA PTENP1 polymorphism rs7853346 may predict GC susceptibility.

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Tag SNPs of long non-coding RNA TINCR affect the genetic susceptibility to gastric cancer in a Chinese population

Cited by 14 publications

References 39 publications

The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer

Association between the rs2288947 polymorphism of the lncRNA TINCR gene and the risk of recurrent miscarriage in a Southern Chinese population

Polymorphisms in lncRNA PTENP1 and the Risk of Gastric Cancer in a Chinese Population

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