PLoS ONE volume 9, issue 5, Pe98317 2014 DOI: 10.1371/journal.pone.0098317 View full text
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Surajit Pathak, Wen-Jian Meng, Hong Zhang, Sebastian Gnosa, Suman Kumar Nandy, Gunnar Adell, Birgitta Holmlund, Xiao-Feng Sun

Abstract: BackgroundTafazzin (TAZ), a transmembrane protein contributes in mitochondrial structural and functional modifications through cardiolipin remodeling. TAZ mutations are associated with several diseases, but studies on the role of TAZ protein in carcinogenesis and radiotherapy (RT) response is lacking. Therefore we investigated the TAZ expression in rectal cancer, and its correlation with RT, clinicopathological and biological variables in the patients participating in a clinical trial of preoperative RT.Method…

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