Tadalafil Preserves Penile Nitric Oxide Synthase from Detrimental Effect of Paroxetine in Rats

Gül, Abdullah; Pastuszak, Alexander W.; Kabasakal, Levent; Bates, Jenna N.; Altınay, Serdar; Çelik, Duygu Sultan; Semerciöz, Atilla; Şerefoğlu, Ege Can

doi:10.5152/eurasianjmed.2018.18160

Cited by 3 publications

(4 citation statements)

References 17 publications

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“…Most research has concentrated on the effect of tadalafil on organic ED. 29 , 30 Our results showed that tadalafil could prevent the changes induced by CUMS including anhedonia and poor sexual function.. In fact, tadalafil is a second-generation, highly selective phosphodiesterase type 5 inhibitor, which can enhance erectile function by increasing the content of cGMP in penile tissue.…”

Section: Discussionmentioning

confidence: 67%

Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

Wang

Zhang

et al. 2023

Sexual Medicine

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Background Few studies have investigated psychogenic sexual dysfunction including psychogenic erectile dysfunction (pED); the effect of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress (CUMS) remains unclear. Aim The aim was to explore the influence of CUMS on sexual behavior of male rats and the effects of tadalafil on that. Methods Adult male rats were divided into 3 groups, including the normal group without CUMS, the model group with 6 weeks’ CUMS, and the tadalafil group with treatment of tadalafil during CUMS. CUMS consists of water deprivation, food deprivation, stroboscopic lightning, white noise, cage tilting, weeding packing, and housing 2 unfamiliar rats. The apomorphine test and vaginal smear test were conducted with the aim to screen out male rats with good erectile function and make preparation for the sexual behavior test, respectively. Outcomes At the end of the study period, the level of anhedonia and sexual function were evaluated by the sucrose preference test, sexual behavior test, and measurement of serum testosterone, dopamine, and 5-HT. Results Sucrose preference showed significant decrease in rats after CUMS. The intromission ratio and total intromission frequency decreased significantly, while the mount latency and ejaculation latency prolonged significantly in CUMS-induced rats when compared with normal rats. Meanwhile, the treatment of tadalafil reversed the level of anhedonia and sexual function in CUMS-induced rats. However, there were no statistical differences in the levels of serum testosterone, dopamine, and 5-HT among groups. Clinical Implications The study constructed an animal model that can provide clinical insights into the mechanism of psychogenic sexual dysfunction and supports the application of tadalafil in pED therapy. Strengths and Limitations We found that CUMS-induced rats exhibited anhedonia and poor sexual function that could be prevented by tadalafil administration. Future research needs to construct the standard of pED model and explore the mechanism of tadalafil on central nervous system. Conclusion Tadalafil could prevent the changes of depression and poor sexual function in rats induced by CUMS, and the method of CUMS and the sexual behavior test should be used in the future for pED modeling.

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Section: Discussionmentioning

confidence: 67%

Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

Wang

Zhang

et al. 2023

Sexual Medicine

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“…Some studies have linked an inhibition of NOS-2 to high concentrations of NO, affecting reproductive functions. It has been reported that it causes erectile dysfunction in men, and ectopic pregnancies and low fertility in women [ 60 , 61 ]. This could be evidenced in the results obtained with the biological model C. elegans exposed to OBs, showing an inhibition in the egg-laying capacity.…”

Section: Discussionmentioning

confidence: 99%

Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans

Castro-Sierra,

Duran-Izquierdo,

Sierra-Marquez

et al. 2024

Toxics

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Optical brighteners (OBs) have become an integral part of our daily lives and culture, with a growing number of applications in various fields. Most industrially produced OBs are derived from stilbene, which has been found in environmental matrices. The main objectives for this work are as follows: first, to identify protein targets for DAST, FB-28, and FB-71, and second, to assess their effects in some behaviors physiologic of Caenorhabditis elegans. To achieve the first objective, each OB was tested against a total of 844 human proteins through molecular docking using AutoDock Vina, and affinities were employed as the main criteria to identify potential target proteins for the OB. Molecular dynamics simulations took and validated the best 25 docking results from two protein databases. The highest affinity was obtained for the Hsp70-1/DAST, CD40 ligand/FB-71, and CD40 ligand/FB-28 complexes. The possible toxic effects that OBs could cause were evaluated using the nematode C. elegans. The lethality, body length, locomotion, and reproduction were investigated in larval stage L1 or L4 of the wild-type strain N2. In addition, transgenic green fluorescent protein (GFP) strains were employed to estimate changes in relative gene expression. The effects on the inhibition of growth, locomotion, and reproduction of C. elegans nematodes exposed to DAST, FB-71, and FB-28 OBs were more noticeable with respect to lethality. Moreover, an interesting aspect in OB was increased the expression of gpx-4 and sod-4 genes associated with oxidative stress indicating a toxic response related to the generation of reactive oxygen species (ROS). In all cases, a clear concentration-response relationship was observed. It is of special attention that the use of OBs is increasing, and their different sources, such as detergents, textiles, plastics, and paper products, must also be investigated to characterize the primary emissions of OBs to the environment and to develop an adequate regulatory framework.

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“…Reports have also shown that PAR alters the activity of nitric oxide synthase (NOS), the effect that could reduce the production of nitric oxide (NO). NO is involved in the activation of the guanylate cyclase enzyme and increases cyclic guanosine monophosphate (cGMP) level in the endothelial smooth muscle cells (Gul et al, 2019). These events improve the relaxation of penile smooth muscle and blood flow into the penile tissue and consequently result in a firm penile erection (Adefegha et al, 2018; Gul et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…NO is involved in the activation of the guanylate cyclase enzyme and increases cyclic guanosine monophosphate (cGMP) level in the endothelial smooth muscle cells (Gul et al, 2019). These events improve the relaxation of penile smooth muscle and blood flow into the penile tissue and consequently result in a firm penile erection (Adefegha et al, 2018; Gul et al, 2019). The use of PAR in the rats model of ED has been well established (Adefegha et al, 2018; Angulo et al, 2001; Tiwari, 2020; Yakubu & Jimoh, 2014).…”

Section: Introductionmentioning

confidence: 99%

Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine‐sexually impaired male rats

Oyeleye

Olasehinde

Odumosu

et al. 2022

Journal of Food Biochemistry

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This study focused on the effect of unripe (UPP) and ripe (RPP) plantain peels' extracts (200 and 400 mg/kg) on sexual behavior, hormonal profiles [testosterone, folliclestimulating hormone (FSH), and luteinizing hormone (LH)], and enzymes [acetylcholinesterase (AChE), phosphodiesterase-5′ (PDE-5), arginase, angiotensin-I converting enzyme (ACE), ecto-5′neucleotidase, and adenosine deaminase (ADA)] in paroxetine (PAR)-induced penile dysfunction rats. From the result, arginase, PDE-5′, ACE, ecto-5′-nucleotidase ADA, and AChE activities, sexual activities, hormonal profile, and NO level were reduced, while thiobarbituric acid reactive species (TBARS) level increased (p < .05) relative to normal control rats. However, treatment with UPP and URP reduced the activities of these enzymes, decreased TBARS levels, and increased hormones, and penile NO levels in PAR-induced rats. Thus, the use of UPP and RPP could be channeled towards the improvement of sexual performance in erectile dysfunction (ED) disorder. Practical applicationsPlantain fruits are a tropical staple food crop commonly consumed at various stages of ripeness and cooking methods. However, its peels are regarded as a waste product with reported cases of environmental menace. Interestingly, plantain peel is being used as a major raw material for industrial applications in the agro-based industries and in folklore for the treatment of many human ailments due to its rich phytochemicals such as polyphenols, carotenoids, alkaloids, etc., which have been reported. A prelude study has also indicated its usefulness in ED management, but further pharmacological investigations are needed to proffer information on its effect in ED management and its anti-androgenic activity in male Wistar rats. The information from this study could be of pharmaceutical importance in designing natural remedies capable of improving penile rigidity, hormone profiles, and alteration of enzymes linked with ED.

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Tadalafil Preserves Penile Nitric Oxide Synthase from Detrimental Effect of Paroxetine in Rats

Cited by 3 publications

References 17 publications

Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress

Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans

Plantain peels restore sexual performance, hormonal imbalance, and modulate nitric oxide production and key enzymes of penile function in paroxetine‐sexually impaired male rats

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