2022
DOI: 10.1590/s2175-97902022e19491
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Tadalafil and Sildenafil illicit association: Stability- indicating HPLC method, photodegradation kinetic and toxicological studies

Abstract: The illicit market of counterfeit medicines containing sildenafil and tadalafil has been causing serious public health problems. Thus, further studies on this illicit association are needed. A stability-indicating HPLC method was developed for simultaneous determination of tadalafil (TAD) and sildenafil (SIL) using a C 18 column (250 x 4.6 mm, 5 µm). Detection was achieved at 284 nm, for TAD, and 292 nm, for SIL. The method was considered to be specific, linear, precise, accurate, robust, and sensitive. In the… Show more

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“…Several alternatives have been suggested regarding the incorporation of forensic information into intelligence (e.g., [18,20,22,25,28,[30][31][32]54,[126][127][128][129][130][131][132]). Recent projects highlight the implementation of laboratory success with the conversion of forensic analysis into forensic intelligence, and some of these are highlighted below [6,26,30,31,101]. Each example represents the tactical implementation of an intelligence strategy.…”
Section: Recent Literature On Forensic Intelligencementioning
confidence: 99%
“…Several alternatives have been suggested regarding the incorporation of forensic information into intelligence (e.g., [18,20,22,25,28,[30][31][32]54,[126][127][128][129][130][131][132]). Recent projects highlight the implementation of laboratory success with the conversion of forensic analysis into forensic intelligence, and some of these are highlighted below [6,26,30,31,101]. Each example represents the tactical implementation of an intelligence strategy.…”
Section: Recent Literature On Forensic Intelligencementioning
confidence: 99%