Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats

Roversi, Katiane; Antoniazzi, Caren Tatiane de David; Milanesi, Laura Hautrive; Rosa, Higor Zuquetto; Kronbauer, Maikel; Rossato, Domênika Rubert; Duarte, Thiago; Bürger, Marilise Escobar

doi:10.1007/s12035-019-1522-5

Cited by 26 publications

(26 citation statements)

References 82 publications

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“…It is important to note that TS administration in both neonatal and adulthood causes increased trophic factor levels (BDNF and FGF-2) in different brain areas. The maturation and survival of neurons and ( Lipsky and Marini, 2007 ; Antoniazzi et al, 2017 ) 5-HT 2A receptor functioning that is involved in the antidepressant activity are related to essential role of BDNF signaling ( Tsybko et al, 2014 ; Popova et al, 2017 ; Roversi et al, 2019 ). In this sense, it is suggested that the influence caused by TS could improve HPA axis signaling and enhance the effects of neurotrophic factors which could consequently bring along improvement in depression-like behaviors in adult rats ( Roversi et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Neonatal TS enriches the experience and improves maturation of newborn animals, positively influencing behaviors and neuroendocrine systems in pups ( Boufleur et al, 2012 , 2013 ; Antoniazzi et al, 2014 ). Others showed that neonatal TS increases neurogenesis and neuroplasticity, improves anxiety-like behaviors and prevents depression-like behaviors ( Richards et al, 2012 ; Freitas et al, 2015 ; Roversi et al, 2019 ). Recent reports have shown that when TS is applied both during the initial periods of development and in adult rats, neurotrophins such as brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 2 (FGF-2) increase in different brain areas.…”

Section: Introductionmentioning

confidence: 99%

“…Recent reports have shown that when TS is applied both during the initial periods of development and in adult rats, neurotrophins such as brain-derived neurotrophic factor (BDNF) and fibroblast growth factor 2 (FGF-2) increase in different brain areas. In addition, dendritic lengths after brain injury increase and memory performance enhances ( Roversi et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors

Balikci

İlbay

Ateş

2020

Front. Behav. Neurosci.

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Recent studies suggest that development of absence epilepsy and comorbid depression might be prevented by increased maternal care of the offspring, in which tactile stimulation induced by licking/grooming and non-nutritive contact seem to be crucial. In this study, we aimed to evaluate the effect of neonatal tactile stimulations (NTS) on absence epilepsy and depression-like behaviors in adulthood. Wistar Albino Glaxo from Rijswijk (WAG/Rij) rat pups with a genetic predisposition to absence epilepsy were divided into tactile stimulation (TS) group, deep touch pressure (DTP) group, maternal separation (MS) group or control group. Between postnatal day 3 and 21, manipulations (TS, DTP, and MS) were carried out for 15 min and three times a day. Animals were submitted to locomotor activity, sucrose consumption test (SCT) and forced swimming test (FST) at five months of age. At the age of six months, the electroencephalogram (EEG) recordings were conducted in order to quantify the spike-wave discharges (SWDs), which is the hallmark of absence epilepsy. The TS and DTP groups showed less and shorter SWDs in later life in comparison to maternally separated and control rats. SWDs’ number and total duration were significantly reduced in TS and DTP groups whereas mean duration of SWDs was reduced only in DTP group ( p < 0.05). TS and DTP also decreased depression-like behaviors measured by SCT and FST in adult animals. In the SCT, number of approaches was significantly higher in TS and DTP groups than the maternally separated and control rats. In the FST, while the immobility latency of TS and DTP groups was significantly higher, only TS group showed significantly decreased immobility and increased swimming time. The results showed that NTS decreases both the number and length of SWDs and the depression-like behaviors in WAG/Rij rats probably by increasing arousal level and causing alterations in the level of some neurotrophic factors as well as in functions of the neural plasticity in the developing rat’s brain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors

Balikci

İlbay

Ateş

2020

Front. Behav. Neurosci.

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“…The TS mechanism in the brain is still unclear, but evidence has suggested that TS affects the hypothalamic-pituitary-adrenal (HPA) axis and brain neurotrophic factors such as brain-derived neurotrophic factor (Bdnf; Antoniazzi et al, 2017 ; Roversi et al, 2019 ). Further, the GABA and glutamate systems are likely targets.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Tactile Stimulation Alters Behaviors in Heterozygous Serotonin Transporter Male Rats: Role of the Amygdala

Roversi

Buizza

Brivio

et al. 2020

Front. Behav. Neurosci.

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The serotonin transporter (SERT) gene, especially the short allele of the human serotonin transporter linked polymorphic region (5-HTTLPR), has been associated with the development of stress-related neuropsychiatric disorders. In line, exposure to early life stress in SERT knockout animals contributes to anxiety-and depression-like behavior. However, there is a lack of investigation of how early-life exposure to beneficial stimuli, such as tactile stimulation (TS), affects later life behavior in these animals. In this study, we investigated the effect of TS on social, anxiety, and anhedonic behavior in heterozygous SERT knockouts rats and wild-type controls and its impact on gene expression in the basolateral amygdala. Heterozygous SERT +/− rats were submitted to TS during postnatal days 8-14, for 10 min per day. In adulthood, rats were assessed for social and affective behavior. Besides, brain-derived neurotrophic factor (Bdnf) gene expression and its isoforms, components of glutamatergic and GABAergic systems as well as glucocorticoid-responsive genes were measured in the basolateral amygdala. We found that exposure to neonatal TS improved social and affective behavior in SERT +/− animals compared to naïve SERT +/− animals and was normalized to the level of naïve SERT +/+ animals. At the molecular level, we observed that TS per se affected Bdnf, the glucocorticoid-responsive genes Nr4a1, Gadd45β, the co-chaperone Fkbp5 as well as glutamatergic and GABAergic gene expression markers including the enzyme Gad67, the vesicular GABA transporter, and the vesicular glutamate transporter genes. Our results suggest that exposure of SERT +/− rats to neonatal TS can normalize their phenotype in adulthood and that TS per se alters the expression of plasticity and stressrelated genes in the basolateral amygdala. These findings demonstrate the potential effect of a supportive stimulus in SERT rodents, which are more susceptible to develop psychiatric disorders.

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“…Given during early developmental periods, TS improves anxiety-like behaviors, prevents preference to addictive drugs and depression-like behaviors [12]. When given in adult rats, however, TS shows bene cial in uence on the brain function, preventing cortical lesion and increasing neurotrophin and dendritic length [15].…”

Section: Introductionmentioning

confidence: 99%

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

İlbay

Balikci

Köktürk

et al. 2020

Preprint

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Background In previous studies, it has been shown that in early developmental period, the high level of tactile stimulations prevent absence epilepsy development and comorbid depression in Wistar-Albino-Glaxo from Rijswijk (WAG/Rij) rats with absence epilepsy. The aim of our study is to examine the effects of neonatal tactile stimulatons on the brain structures that previously defined as the focus of epilepsy in the rat brain with genetic absence epilepsy. Results In the present research, morphology and density of dendritic spines were analyzed in the somatosensory cortex (SoCx) in WAG/Rij rats with absence epilepsy, sensory experienced WAG/Rij rats (tactile-stimulated and maternal separated) and healthy Wistar (non-epileptic) rats. To achieve this, a Golgi-Cox method was used. Dendritic spine number in layer V of the SoCx has been detected significantly higher in adult WAG/Rij rats at post natal day 150 in comparison to non-epileptic adult control Wistar rats (p < 0,001). Moreover, quantitative analyses of dendrite structure in adult WAG/Rij rats showed a decrease in dendrite spine density of pyramidal neurons of SoCx which occurred in early neonatal exposure to maternal separation (MS) and tactile stimulation (TS) (p < 0,001). Conclusions Our findings provide the first evidence that tactile stimulations during the early postnatal period have a long-term impact on dendrite structure in WAG/Rij rat’s brain and suggest a reduction in dendrite spine density is linked to absence seizure reduction.

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Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats

Cited by 26 publications

References 82 publications

Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors

Neonatal Tactile Stimulations Affect Genetic Generalized Epilepsy and Comorbid Depression-Like Behaviors

Neonatal Tactile Stimulation Alters Behaviors in Heterozygous Serotonin Transporter Male Rats: Role of the Amygdala

Neonatal Tactile Stimulation Modulates Dendritic Spine Densities in Somatosensory Cortex of Adult WAG/Rij rats

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