Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis

Fereig, Salma A.; El-Zaafarany, Ghada M.; Arafa, Mona G.; Abdel-Mottaleb, Mona M.A.

doi:10.1016/j.carbpol.2021.118238

Cited by 39 publications

(25 citation statements)

References 107 publications

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“…When drug delivery systems are modified by polysaccharides, receptors on target cells trigger phagocytosis, producing active targeting effects [ 155 ]. Polysaccharide-based transdermal drug delivery systems are now widely used in the medical field and in combination with other drugs to address therapeutic diseases, such as immunotherapy [ 156 ], diabetes [ 56 ], psoriasis [ 157 ], etc. They are described in more detail in the following sections.…”

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

“…CS nanoparticles loaded with tacrolimus utilized the positive charge of CS to combine with the negative charge sites of the skin, enhancing the deposition rate of tacrolimus in the skin, with 82.0% ± 0.6 of the drugs retained in the skin. Its therapeutic efficacy is superior to commercially available tacrolimus ® ointment [ 157 ].…”

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

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Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

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Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

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“…More importantly, when compared to the commercial BD cream, BD-T significantly improved the risk–benefit ratio showing a favorable therapeutic effect in patients with psoriasis. Likewise, to enhance the transdermal permeability of Tacrolimus (TAC), which is a lipophilic natural macrolide widely used in the treatment of psoriasis as a powerful immunosuppressant ( Fereig et al, 2021 ), Parkash et al constructed transfersomes using the rotary evaporation method with TAC, and tested the drug permeation followed by assessing its antipsoriatic efficacy ( Ved Parkash et al, 2018 ). Compared to the conventional liposomes, a superior permeability was obtained when TAC was packaged into transfersomes, as assessed by pharmacokinetic and pharmacodynamic parameters, which was consistent with a gain in anti-psoriatic activities in both in vivo and in vitro studies.…”

Section: Nanoparticlesmentioning

confidence: 99%

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Qin

Dai

et al. 2022

Front. Bioeng. Biotechnol.

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Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

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“…Recently, Fereig and colleagues, in 2014, developed chitosan nanoparticles with an anti-proliferative molecule, i.e., tacrolimus, which acts via T-lymphocytic cell inhibition. They reported skin deposition of 82% of the tacrolimus, which was significantly greater in comparison to pure Tacrolimus ® ointment, which showed about 34.0% skin retention [14].…”

Section: Introductionmentioning

confidence: 98%

Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

et al. 2021

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Psoriasis is a chronic inflammatory autoimmune disorder that moderately affects social and interpersonal relationships. Conventional treatments for psoriasis have certain problems, such as poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin. Colloidal drug delivery systems overcome the pitfalls of conventional approaches for psoriasis therapeutics and have improved patient safety parameters, compliance, and superior effectiveness. They also entail reduced toxicity. This comprehensive review’s topics include the pathogenesis of psoriasis, causes and types of psoriasis, conventional treatment alternatives for psoriasis, the need for colloidal drug delivery systems, and recent studies in colloidal drug delivery systems for the treatment of psoriasis. This review briefly describes colloidal drug delivery approaches, such as emulsion systems—i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems—i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems—i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles. The review was compiled through an extensive search of the literature through the PubMed, Google Scholar, and ScienceDirect databases. A survey of literature revealed seven formulations based upon emulsion systems, six vesicular drug delivery systems, and fourteen particulate systems reported for antipsoriatic drugs. Based on the literature studies of colloidal approaches for psoriasis management carried out in recent years, it has been concluded that colloidal pharmaceutical formulations could be investigated broadly and have a broad scope for effective management of many skin disorders in the coming decades.

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Tacrolimus-loaded chitosan nanoparticles for enhanced skin deposition and management of plaque psoriasis

Cited by 39 publications

References 107 publications

Polysaccharide-Based Transdermal Drug Delivery

Polysaccharide-Based Transdermal Drug Delivery

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Promising Strategies of Colloidal Drug Delivery-Based Approaches in Psoriasis Management

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