Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: randomised European multicentre trial

Kelly, Déirdre; Jara, Paloma; Rodeck, Burkhard; Lykavieris, Panayotis; Burdelski, M.; Becker, Michael; Gridelli, Bruno; Boillot, Olivier; Manzanares, J.; Reding, Raymond

doi:10.1016/s0140-6736(04)17060-8

Cited by 120 publications

(87 citation statements)

References 20 publications

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“…Further investigations are necessary to elucidate this question. Finally, at the multivariate analysis, the use of tacrolimus in pediatric LT was correlated with a lower rate of AR and steroid-resistant AR, confirming the superior efficacy of tacrolimus compared to cyclosporine as immunoprophylaxis in this setting, as recently reported by a European multicenter study (29).…”

Section: Discussionsupporting

confidence: 81%

Living-Related Versus Deceased Donor Pediatric Liver Transplantation: A Multivariate Analysis of Technical and Immunological Complications in 235 Recipients

Bourdeaux

Darwish

Jamart

et al. 2007

American Journal of Transplantation

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Timely access to a living donor (LD) reduced pretransplant mortality in pediatric liver transplantation (LT).We hypothesized that this strategy may provide better posttransplant outcome. Between July 1993 and April 2002, 235 children received a primary LT from a LD (n = 100) or a deceased donor (DD) (n = 135). Demographic, surgical and immunological variables were compared, and respective impact on posttransplant complications was studied using a multivariate analysis. Five-year patient survival rates were 92% and 85% for groups LD and DD, respectively (p = 0.181), the corresponding graft survival rates being 89% and 77% (p = 0.033). At multivariate analysis: (1) type of donor (DD) was correlated with higher rate of artery thrombosis (p < 0.012); (2) biliary complication rate at 5 years was 29% and 23% for groups LD and DD, respectively (p = 0.451); (3) lower acute rejection incidence could be correlated with type of donor (DD) (p = 0.001), and immunosuppressive therapy (tacrolimus) (p < 0.001). We conclude that (1) according to the multivariate analysis, LT with LD provided similar patient and graft outcome, when compared to DD; (2) a higher rate of artery thrombosis and a lower rate of rejection were observed in group DD; (3) this study comfirms the efficacy of tacrolimus for immunoprophylaxis, whatever the type of organ donor is.

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Section: Discussionsupporting

confidence: 81%

Living-Related Versus Deceased Donor Pediatric Liver Transplantation: A Multivariate Analysis of Technical and Immunological Complications in 235 Recipients

Bourdeaux

Darwish

Jamart

et al. 2007

American Journal of Transplantation

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“…CsA was previously considered as a calcineurin inhibitor that is widely used to prevent acute rejection after liver transplantation [9]. CsA has a narrow therapeutic range and shows large inter- and intra-individual pharmacokinetic variability [10].…”

Section: Introductionmentioning

confidence: 99%

A Mechanism Study Underlying the Protective Effects of Cyclosporine-A on Lung Ischemia-Reperfusion Injury

Zhong-ya²,

Fang³

2017

Pharmacology

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Aim: This study is aimed at validating the hypothesis that administration of cyclosporine-A (CsA) would be protective in lung ischemia-reperfusion (I/R) injury and in exploring the underlying mechanism. Methods: Rabbits were divided into 4 groups: the control, sham operation, I/R, and I/R with CsA treatment. Flow cytometry was used to measure the mitochondrial membrane potential. Laser scanning confocal microscope was used to analyze mitochondrion permeability transition pore (MPTP). The apoptotic cell was detected by the TUNEL staining. Western blot was performed to analyze the protein expression levels. Results: CsA not only attenuated the histopathologic alterations in lung and mitochondria after I/R injury, but also attenuated I/R injury through increasing MPP and inhibiting MPTP opening. Besides, CsA attenuated I/R injury through suppressing the release of cytochrome-c (CytC), inhibiting cell apoptosis and decreasing the expression levels of cyclophilin-D (Cyp-D), adenine nucleotide translocase 1 (ANT1) and voltage-dependent anion channel 1 (VDAC1). Finally, we found that Cyp-D knockdown inhibits I/R injury-induced MPTP opening and cell apoptosis. Conclusion: Our study found that the protective role of CsA on lung I/R injury depends on the inhibition of MPTP and CytC release, suppression of the activation of mitochondrial apoptosis pathway and the expressions of apoptotic-related proteins, as well as the decreased expression levels of ANT1 and VDAC1.

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“…Immunosuppressants which suppress or prevent immune reactions, are clinically used to prevent allograft rejection 1 after transplantation (3,4) and to treat autoimmune diseases such as psoriasis, rheumatoid arthritis and Crohn's disease (5). The calcineurin inhibitors, tacrolimus and cyclosporine A, are widely used as immunosuppressants in the clinic and are known to inhibit T-cell function, although the activity of tacrolimus on immune suppression was 100 times higher than that of cyclosporine A (6).…”

Section: Introductionmentioning

confidence: 99%

Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats

et al. 2009

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Tacrolimus and steroids versus ciclosporin microemulsion, steroids, and azathioprine in children undergoing liver transplantation: randomised European multicentre trial

Cited by 120 publications

References 20 publications

Living-Related Versus Deceased Donor Pediatric Liver Transplantation: A Multivariate Analysis of Technical and Immunological Complications in 235 Recipients

Living-Related Versus Deceased Donor Pediatric Liver Transplantation: A Multivariate Analysis of Technical and Immunological Complications in 235 Recipients

A Mechanism Study Underlying the Protective Effects of Cyclosporine-A on Lung Ischemia-Reperfusion Injury

Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats

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