TAB2 Promotes the Stemness and Biological Functions of Cervical Squamous Cell Carcinoma Cells

Abstract

Cancer stem cells are a key population participating in the promotion of the cervical cancer progression through interacting with cancer cells. Existing studies have preliminary revealed that cervical cancer stem cells contribute to tumor recurrence and chemotherapy resistance. However, the specific mechanisms involved in regulating cell functions remain largely unknown. Here, we analyzed published data from public databases and our global transcriptome data, thus identifying cancer-related signaling pathways and molecules. According to our findings, upregulated TAB2 was correlated to stem cell-like properties of cervical cancer. Immunohistochemistry staining of TAB2 in normal and cervical cancer tissues was performed. The cell function experiments demonstrated that knockdown of TAB2 reduced the stemness of cervical cancer cells and, importantly, prevented cervical cancer progression. Collectively, the therapeutic scheme targeting TAB2 may provide an option for overcoming tumor relapse and chemoresistance of cervical cancer via obstructing stemness maintenance.

A multi-omics-based investigation of the prognostic and immunological impact of necroptosis-related mRNA in patients with cervical squamous carcinoma and adenocarcinoma

“…The knockdown of the TAB2 gene significantly inhibits cell proliferation and induces cell apoptosis. www.nature.com/scientificreports/ Moreover, the regulatory mechanism of TAB2 in cancer stem cells (CSCs) is related to promoting the malignant transformation and invasiveness of CC, which is a prognostic marker of CC 52 . Our results are consistent with these studies.…”

miR-142: A Master Regulator in Hematological Malignancies and Therapeutic Opportunities

“…Additionally, miR-142-3p targets the 3’UTR of TAB2 mRNA, and the knockout of TAB2 was associated with granulocytic differentiation [ 36 ]. Notably, TAB2 has been shown to be a major activator of the NF-κB pathway and the maintenance of cancer stem cell-like properties in cervical squamous cell carcinoma cells [ 213 ]. Reduced miR-142-3p levels, as Wang et al demonstrated among AML patients, can therefore contribute to APL development by relieving its inhibition of CCNT2 and TAB2 targets [ 36 , 207 ].…”