T1693 High Nitrate Intake May Be Related to GERD: An Ecologic Study

Nasseri‐Moghaddam, Siavosh; Mofid, Azadeh; Razjouyan, Hadi; Nouraie, Mehdi; Malekzadeh, Reza

doi:10.1016/s0016-5085(10)62571-1

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…tLESRs are currently considered as the main mechanism of GERD [5][6][7], but we still have gaps in our knowledge in mechanisms of GERD generation and cause(s) of its increased prevalence. In an ecologic study in Tehran, Iran, our group found that frequent (weekly or more) acid regurgitation was more common in people residing in areas where drinking water contained[100 mg/ l nitrate than those living in regions with water-nitrate \100 mg/l (25.5% vs. 12.0%, OR/95%CI: 2.53/1.36-4.73, p = 0.006) [14]. This result suggested an association, but not a cause and effect relation.…”

Section: Discussionmentioning

confidence: 94%

“…This has led to a higher intake of nitrates/nitrites by humans through processed food, vegetables, and water [12,13]. Recent ecologic data have linked high nitrate content of drinking water to increased prevalence of acid regurgitation [14]. In addition, animal studies have shown that when reflux is induced in mice, they develop significant esophagitis only when fed a diet containing nitrates [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Nitrate Reductase Activity and Erosive Gastro-esophageal Reflux Disease: A Nitrate Hypothesis for GERD Pathogenesis

et al. 2011

Self Cite

View full text Add to dashboard Cite

Oral nitrate reductase activity in erosive GERD patients is higher than controls. Therefore, any dietary nitrate load generates more nitrite in these patients. This excess nitrite at the gastroesophageal junction, may potentially contribute to the development of GERD. This is the first report linking oral nitrite production to erosive GERD in man. We suggest that a "nitrate hypothesis" may answer yet unanswered questions about GERD pathogenesis. If confirmed, it may change our understanding of mechanisms of GERD and provide novel therapeutic targets.

show abstract