T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata

Tembhre, Manoj Kumar; Sharma, Vaishali

doi:10.1111/bjd.12396

Cited by 98 publications

(149 citation statements)

References 39 publications

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“…It has been revealed that SNPs of the IL17RA gene are associated with AA onset age in Korean patients [98]. Serum cytokine levels of IL-17A are significantly increased, and TGFβ1 is significantly decreased, in patients with AA compared with controls [99]. In AA lesions, infiltration of CD4 + IL-17A + T H cells have been found in the dermis, particularly around hair follicles [100] [101].…”

Section: Th17 Cells May Contribute To Alopecia Areata Developmentmentioning

confidence: 99%

The role of lymphocytes in the development and treatment of alopecia areata

Guo

Cheng

Shapiro

et al. 2015

Expert Review of Clinical Immunology

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SummaryAlopecia areata (AA) development is associated with both innate and adaptive immune cell activation, migration to peri-and intra-follicular regions, and hair follicle disruption. Both CD4+ and CD8+ lymphocytes are abundant in AA lesions; however, CD8+ cytotoxic T lymphocytes are more likely to enter inside hair follicles, circumstantially suggesting that they have a significant role to play in AA development. Several rodent models recapitulate important features of the human autoimmune disease and demonstrate that CD8+ cytotoxic T lymphocytes are fundamentally required for AA induction and perpetuation. However, the initiating events, the selfantigens involved, and the molecular signaling pathways, all need further exploration. Studying CD8+ cytotoxic T lymphocytes and their fate decisions in AA development may reveal new and improved treatment approaches.

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Section: Th17 Cells May Contribute To Alopecia Areata Developmentmentioning

confidence: 99%

The role of lymphocytes in the development and treatment of alopecia areata

Guo

Cheng

Shapiro

et al. 2015

Expert Review of Clinical Immunology

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“…The main reason for evaluation of Th1 and Th2 cytokine mRNA transcripts was the lack of clear and convincing evidence with respect to the exact role of these cytokines and their contributions in AA pathogenesis [20,21].…”

Section: Discussionmentioning

confidence: 99%

“…However, there is controversy in the literature about AA being a Th1 or Th2 autoimmune phenomenon, or both [3][4][5][6]. Thus, identifying the molecular switches that regulate differentiation of CD4+ T cells into Th1 and Th2 effector cells in diseased subjects is the keystone for the characterization of the errors in the function of the immune system.…”

Section: Introductionmentioning

confidence: 99%

Study of Th1/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata

Sadeghi

Sanati

Taghizadeh

et al. 2015

Acta Microbiologica et Immunologica Hungarica

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Alopecia areata represents an autoimmune pathological process driven primarily by cellular aberrations contained within the immune system, which activates various humoral and cellular elements of the immune response. The aim of this study was to determine the mRNA expression levels of T-bet and GATA-3 as potential inducers of T helper (Th)1 and Th2 differentiation, respectively, as well as Th1(IFN-γ) and Th2(IL-4) cytokine mRNA expression in patients with alopecia areata. Using real-time reverse transcriptase PCR (RT-PCR), the relative amounts of T-bet, GATA-3, IFN-γ, and IL-4 mRNA transcripts were determined in PBMCs from 20 Iranian patients with alopecia areata and compared with those of 20 healthy control subjects. In comparison with the normal group, T-bet and IFN-γ mRNA expression levels were signifi cantly up-regulated in the alopecia areata patients, while GATA-3 and IL-4 mRNA expression levels were down-regulated. Notably, positive correlation (P < 0.05) was found between IFN-γ and T-bet levels in patients and controls. In addition, signifi cant positive correlations existed between GATA-3 and IL-4 (P < 0.05). These results indicate that a Th1/Th2 imbalance exists in alopecia areata, and it may be implicated in the pathogenesis of disease.

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“…Treg hücreler, TGF-β yardımıyla CD4+, CD8+ T hücre ve NK hücre yanıtlarını baskılayarak otoimmün hastalıkların gelişimini engellemektedirler 15 . Alopesi areata hastalarında yapılan çalışmalarda, serum TGF-β1 düzeylerinin düşük olduğu ve bunun Treg hücre fonksiyon bozukluğu ile ilişkili olduğu bildirilmiştir 16 . İmmünomodülatuvar ilaçların Treg hücreleri üzerindeki etkileri hakkında farklı çalışmalar bulunmasına karşın, güncel bir in-vitro çalışmada leflunomidin Treg hücrelerin efektör T hücreleri üzerindeki antiproliferatif etkisini baskıladığı, metotreksatın ve infliksimabın ise böyle bir etkisinin olmadığı bildirilmiştir 17 .…”

Section: Discussionunclassified

A case of lenflunomide-induced alopecia areata

Açıkgöz¹,

Yeniay²,

Çalışkan³

et al. 2015

TURKDERM

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Leflunomide is an immunomodulatory drug widely used in the treatment of inflammatory arthritis, especially in rheumatoid arthritis and psoriatic arthritis. The common side effects of leflunomide are hepatopathy, hypertension, various gastrointestinal complaints and transient hair loss, which are all mild and reversible. Although leflunomide is associated with transient hair loss, only one case of leflunomide-induced alopecia areata has been reported previously. In this case report, we present a 38-year-old male patient who suffered from alopecia areata after leflunomide therapy. (Turkderm 2015; 49: 78-80)

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T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata

Cited by 98 publications

References 39 publications

The role of lymphocytes in the development and treatment of alopecia areata

The role of lymphocytes in the development and treatment of alopecia areata

Study of Th1/Th2 balance in peripheral blood mononuclear cells of patients with alopecia areata

A case of lenflunomide-induced alopecia areata

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