2012
DOI: 10.1083/jcb.201111136
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Abstract: TLR9 localizes to a novel intracellular compartment called the T granule to promote immune signaling by platelets.

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Cited by 162 publications
(188 citation statements)
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References 42 publications
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“…Recently, a fourth electron-dense tubular system compartment, called the T-granule, was discovered and, intriguingly, colocalizes with TLR9. 27 Many of these proteins translocate to the platelet surface and are released upon platelet activation. Other secreted proteins are located basally on the platelet membrane and/or within other subcellular stores (Table 1).…”
Section: Platelets In Sepsismentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, a fourth electron-dense tubular system compartment, called the T-granule, was discovered and, intriguingly, colocalizes with TLR9. 27 Many of these proteins translocate to the platelet surface and are released upon platelet activation. Other secreted proteins are located basally on the platelet membrane and/or within other subcellular stores (Table 1).…”
Section: Platelets In Sepsismentioning
confidence: 99%
“…22,27 TLR9 is expressed on the plasma membrane and in the cytoplasm of quiescent human platelets, and its surface expression increases upon activation of platelets with agonists such as thrombin. 27,28 TLR9 is a ligand for unmethylated CpG islands in viral and bacterial DNA, suggesting a previously unrecognized system of pathogen sensing by human platelets. Moreover, TLR9 binds a carboxyalkylpyrrole protein adduct that may serve as a PAMP, resulting in platelet activation, aggregation, and granule secretion and thrombosis.…”
Section: Platelets In Sepsismentioning
confidence: 99%
“…Тромбоциты, экспрес-сирующие TLR7, вовлечены в ответ организма на вирусные инфекции. TLR9 представлен в тубуляр-ной системе тромбоцитов и действует как рецеп-тор для островков неметилированных последова-тельностей CpG, характерных для бактериальной и вирусной ДНК [14]. Активация тромбоцитов че-рез все перечисленные TLR приводит к высвобож-дению иммуномодулирующих агентов, активации других клеток и представлению им патогенов для фагоцитоза [15].…”
Section: тромбоциты как сенсоры бактерийunclassified
“…ПДИ изобилует в эндоплазматическом ретикулуме ядросодержащих клеток. Она также находится в мелких секреторных гранулах эндотелиальных клеток и т-гранулах тром-боцитов [5,22], а также и во внеклеточном простран-…”
Section: протеин дисульфид изомеразаunclassified