T cells and T-cell subsets in mycosis fungoides and parapsoriasis. A study of 18 cases with anti-human T-cell monoclonal antibodies and histochemical techniques

Buechner, S. A.

doi:10.1001/archderm.120.7.897

Cited by 15 publications

(6 citation statements)

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“…In addition, other variants of CTCL such as mycosis fungoides and pagetoid reticulosis can demonstrate a CD8 (+) rather than a CD4 (+) T-cell immunophenotype. [15][16][17] CD8 (+) cutaneous T-cell lymphomas (CTCL) are seen in only 4% of the cases and few cases, such as CD8 (+) mycosis fungoides-like CTCL, may have an aggressive clinical course. 18 In summary, CD30+ lymphoproliferative disorders may have overlapping clinical and histopathologic features.…”

Section: Discussionmentioning

confidence: 99%

CD8-Positive Primary Cutaneous Anaplastic Large T-Cell Lymphoma (PCALCL): Case Report and Review of This Unusual Variant of PCALCL

Plaza

Ortega

Lynott

et al. 2010

The American Journal of Dermatopathology

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Primary cutaneous anaplastic large T-cell lymphoma (PCALCL) is a well-defined CD30-positive lymphoproliferative disorder with relatively good prognosis and response to treatment. We describe a case of PCALCL expressing CD8. The patient is a 57-year-old man that clinically presented with an ulcerated nodule in his left middle finger. Histopathologic sections showed an ulcerated epidermis with a diffuse lymphocytic infiltrate in the superficial dermis with focal epidermotropism. The large cohesive atypical cells were admixed with a reactive infiltrate composed of neutrophils, eosinophils, and small lymphocytes. Immunohistochemical studies showed the tumor cells to be strongly positive for CD8, CD30, and TIA-1, focally positive for CD3, and negative for CD4, CD20, CD56, Anaplastic Lymphoma Kinase (ALK-1), and HSV. Epstein-Barr virus by in situ hybridization was negative. The diagnosis of a CD8+ PCALCL was confirmed. There is limited precedent literature regarding CD8-positive PCALCL and this case falls within the clinical and histopathologic spectrum of CD30+ lymphoproliferative disorders. CD8/CD30 coexpression is rare in PCALCL and may have important clinical and prognostic implications. To the best of our knowledge there are only 4 previously reported cases describing similar findings.

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Section: Discussionmentioning

confidence: 99%

CD8-Positive Primary Cutaneous Anaplastic Large T-Cell Lymphoma (PCALCL): Case Report and Review of This Unusual Variant of PCALCL

Plaza

Ortega

Lynott

et al. 2010

The American Journal of Dermatopathology

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“…In only 5% of patients is the infiltrate CD8 positive. 8,9 Previous studies have analysed the immunophenotype of juvenile patients and identified similar features to those presenting in adults. 10 This study has identified an unusually high number of CD8-positive cases of CTCL presenting in childhood.…”

Section: Discussionmentioning

confidence: 99%

CD8‐positive juvenile onset mycosis fungoides: an immunohistochemical and genotypic analysis of six cases

Whittam

Calonje

Orchard

et al. 2000

British Journal of Dermatology

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“…[1][2][3][4][5][6] However, the immunophenotype of the epitheliotropic T cells in canine CTCL are TCR ␥␦ CD8 [7][8][9][10] whereas in human MF and SS, they are TCR ␣␤ CD4 + in the vast majority of cases. [11][12][13][14] Occasional reports of human CD8 + CTCL have also been described, essentially in Pagetoid reticulosis, a rare form of CTCL characterized by a strong epidermotropic lymphoid infiltrate. [15][16][17] Established cell lines are an important tool for the study of molecular mechanisms involved in the transformation process induced by carcinogens, the phenotypic properties of transformed hematopoietic cells, and the regulatory mechanisms involved in cell replication and differentiation.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a canine long-term T cell line (DLC 01) established from a dog with Sézary syndrome and producing retroviral particles

Ghernati¹,

Auger²,

Chabanne

et al. 1999

Leukemia

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The canine DLC 01 cell line derives from a lymph node of a dog with Sé zary syndrome. The DLC 01 cell phenotype is CD4 ؊ , CD8؉ , CD45 ؉ , DQ ؉ , similar to that of original cells after treatment with dimethylsulfoxide or phorbol myristate. Canine cutaneous T cell lymphoma are usually CD4Ϫ , CD8 ؉ in contrast to their human counterparts which are CD4 ؉ , CD8 ؊ . Therefore, the DLC 01 cell line appears to be a unique model to study the mechanism of all surface molecule expression in vitro. Viral particles with retrovirus type-C morphology were found in ultrathin sections of DLC 01 cell pellets. Retroviral particles are spontaneously produced after the 50th cell passage or after induction with 0.5% dimethylsulfoxide. This is the first description of a dog lymphoid cell line spontaneously growing and producing a retrovirus. It was found to share several features in common with feline and murine leukemia viruses.

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T cells and T-cell subsets in mycosis fungoides and parapsoriasis. A study of 18 cases with anti-human T-cell monoclonal antibodies and histochemical techniques

Cited by 15 publications

References 0 publications

CD8-Positive Primary Cutaneous Anaplastic Large T-Cell Lymphoma (PCALCL): Case Report and Review of This Unusual Variant of PCALCL

CD8-Positive Primary Cutaneous Anaplastic Large T-Cell Lymphoma (PCALCL): Case Report and Review of This Unusual Variant of PCALCL

CD8‐positive juvenile onset mycosis fungoides: an immunohistochemical and genotypic analysis of six cases

Characterization of a canine long-term T cell line (DLC 01) established from a dog with Sézary syndrome and producing retroviral particles

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