T-cell subsets in cutaneous sarcoidosis

Buechner, S. A.

doi:10.1001/archderm.119.9.728

Cited by 13 publications

(6 citation statements)

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“…This discrepancy might be due to differences in the cellular composition of the inflammatory inflltrates, the decisive factor most probably being the presence of activated T cells (Nickoloff et aL, 1985); these cells are generally considered to be the source of IFN-y (Kirchner & Marcucci, 1984), a lymphokine which has been shown to be capable of inducing HLA-DR antigen on keratinocytes invitro (Bashame^tj/., 1984;Aubock tr a/., 1985). A number of dermatoses in which we found HLA-DR + keratinocytes have recently been reported to contain activated T-Iymphocytes in the dermal infiltrates (Buechner, Winkelmann & Banks, 1983, 1984Ralfkiaer & Wantzin, 1984) Also, our double labelling experiments confirmed the presence of activated T cells (Leu 4+ , HLA-DR-I-or Leu 4 + , TEC-MLR-3+ ) in skin disorders associated with HLA-DR + keratinocytes. In view of this, however, it is surprising that comparable numbers of activated T-Iymphocytes were also found in the dermal infiltrates of those dematoses in which HLA-DR -\-keratinocytes were not found (i.e.…”

Section: Discussionsupporting

confidence: 82%

HLA-DR expression on keratinocytes is a common feature of diseased skin

et al. 1986

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Biopsy specimens from 185 patients with 52 different skin disorders were investigated by indirect immunofluorescence staining for the presence of HLA-DR bearing keratinocytes and their association with an underlying inflammatory infiltrate and in particular with activated (HLA-DR-positive, Leu-4-positive) T lymphocytes. HLA-DR expression on keratinocytes was demonstrated in 38 dermatoses, including lymphocytic vasculitis, lupus erythematosus, morphea, vitiligo, lichen planus, cutaneous T-cell lymphoma, various infectious dermatoses, allergic contact dermatitis, granulomatous dermatoses, Sweet's syndrome, lichen sclerosus and erythema nodosum. In 27 of these this had not previously been reported. Occurrence of HLA-DR on keratinocytes was invariably linked to the presence of a lymphocytic infiltrate containing numerous activated T-cells (Leu-4 +, HLA-DR +) whereas such infiltrates were not accompanied by HLA-DR expression on keratinocytes in all the dermatoses investigated, as in pseudolymphoma and erythema anulare centrifugum. However, HLA-DR positive keratinocytes were consistently absent in skin disorders lacking any significant lymphocytic infiltration (e.g. leukocytoclastic vasculitis, bullous autoimmune dermatoses, genodermatoses and mastocytosis). Although it has been suggested that HLA-DR-positive keratinocytes are involved in various immune responses of the skin, their exact functional significance is, as yet, unknown.

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Section: Discussionsupporting

confidence: 82%

HLA-DR expression on keratinocytes is a common feature of diseased skin

et al. 1986

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“…that may be associated with impaired cell-mediated immunity and T-cell subset abnormalities 1151. The fact that the composition of the inflammatory infiltrate in our patient was similar to that found in patients with sarcoidosis [8] and delayed hypersensitivity reaction 19) also lends support to the theory that GANS is an immunologically mediated disorder elicited by yet unknown antigens present in the walls of CNS vessels. ulomatous angiitis is uncommon.…”

Section: Discussionsupporting

confidence: 81%

Isolated granulomatous angiitis of the spinal cord

Caccamo

García

1992

Annals of Neurology

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We describe a 31-year-old diabetic man, with granulomatous angiitis confined to the spinal cord, who developed rapidly progressive spastic paraplegia, clinically interpreted as being secondary to a spinal cord infarct. At the time of autopsy, vasculitis was limited to the spinal cord, without involvement of cerebral vessels. The inflammatory cells were predominantly CD4+ T lymphocytes, with few CD8+ T and B lymphocytes. The phenotypical composition of the inflammatory infiltrate is similar to that described in other granulomatous disorders such as sarcoidosis and tuberculin reaction.

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“…It has been stated that these two disorders represent "very similar immunological reactions" (6). Certainly, the excess of T-helper/inducer cells observed in granuloma annulare is also present in cutaneous sarcoidosis (11,12,14). In addition, interleukin 2 secretion appears to be important in the pathogenesis of both diseases (29).…”

Section: Discussionmentioning

confidence: 99%

“…An association between the two disorders has been suggested by the histologic occurrence of granuloma annulare in skin lesions of some patients with systemic sarcoidosis (6), while both conditions have increased scrum macrophage migration inhibition activity (5,6) and defective neutrophil migration (10). From the finding of a high helper: suppressor T lymphocyte ratio in lesions from both groups by cell-surface phenotype (7,8,(11)(12)(13)(14) it has been hypothesized that these disorders represent similar cell-mediated immune reactions (7).…”

mentioning

confidence: 99%

“…When used in conjunction with immunoperoxidase techniques, monoclonal antibodies have been valuable tools in studies of the immunopathology of granulomatous inflammation (8,II,12,14,20). In the present study we used antibody markers against T-lymphocyte subpopulations, Langerhans' cells, interleukin 2, and interleukin 2 receptors to characterize further the cutaneous infiltrate of granuloma annulare.…”

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confidence: 99%

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Immunopathologic Demonstration of T Lymphocyte Subpopulations and Interleukin 2 in Graneloma Annulare

Modlin

Horwitz

Jordan

et al. 1984

Pediatric Dermatology

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Immunopathologic aspects of granuloma annulare were studied in frozen sections of nine skin biopsy specimens with monoclonal antibodies directed against T lymphocytes, Langerhans' cells, interleukin 2, and interleukin 2 receptors in conjunction with immunoperoxidase techniques. The predominant lymphocyte was an activated T lymphocyte (Leu 1+, HLA-DR+) with an excess of helper/inducer phenotype (Leu 3a+) as compared with suppressor/cytotoxic phenotype (Leu 2a+). Langerhans' cells were increased in the epidermis and numerous OKT6+ cells were observed in the perivascular and granulomatous infiltrate. Both interleukin 2-positive cells and interleukin 2 receptor-positive cells were identified in the dermal lesions according to observed reactivity with the corresponding monoclonal antibodies. These findings suggest that a cell-mediated immune response producing cytokines may be important in the pathogenesis of granuloma annulare. Comparison of these results with skin specimens from patients with sarcoidosis and from a patient with granuloma annulare having some of the histologic features of sarcoidosis, suggests that the cutaneous infiltrate in granuloma annulare represents a response distinct from that of sarcoidosis.

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T-cell subsets in cutaneous sarcoidosis

Cited by 13 publications

References 0 publications

HLA-DR expression on keratinocytes is a common feature of diseased skin

HLA-DR expression on keratinocytes is a common feature of diseased skin

Isolated granulomatous angiitis of the spinal cord

Immunopathologic Demonstration of T Lymphocyte Subpopulations and Interleukin 2 in Graneloma Annulare

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