2002
DOI: 10.1002/1521-4141(200207)32:7<2055::aid-immu2055>3.0.co;2-q
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Myasthenia gravis (MG) is an autoimmune disease caused by T cell‐dependent antibody‐mediated reduction of acetylcholine receptors (AChR) at the neuromuscular junction. Immunization of animals with Torpedo californica AChR (TAChR) results in an experimental model of MG. We used the variable regions of α and β T cell receptor (TCR) genes recognizing an immunodominant peptide containing amino acids 146–162 from the α subunit of TAChR presented in the context of I‐Ab to generate TCR‐transgenic mice. We found that … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
10
1

Year Published

2003
2003
2012
2012

Publication Types

Select...
4

Relationship

1
3

Authors

Journals

citations
Cited by 4 publications
(11 citation statements)
references
References 59 publications
(62 reference statements)
0
10
1
Order By: Relevance
“…1A, B and C). The B cell deficiency was also apparent in the blood of § g transgenic mice [17]. Macrophages and NK cells were, on average, equivalent in mice of all genotypes ( Fig.…”
Section: Reduced B Cell Numbers In > I Transgenic Micementioning
confidence: 76%
See 4 more Smart Citations
“…1A, B and C). The B cell deficiency was also apparent in the blood of § g transgenic mice [17]. Macrophages and NK cells were, on average, equivalent in mice of all genotypes ( Fig.…”
Section: Reduced B Cell Numbers In > I Transgenic Micementioning
confidence: 76%
“…We also found a subset of g transgenic mice with dramatically lower B cells in the blood and a profound deficit of both B and T cell numbers in the spleen (Fig. 1B and C); we determined this subset to be homozygous for the g transgene by breeding with wt mice [17]. Thus, the reduced splenic cellularity in § g transgenic mice was chiefly due to reduced numbers of B cells.…”
Section: Reduced B Cell Numbers In > I Transgenic Micementioning
confidence: 76%
See 3 more Smart Citations