Arch Pediatr Adolesc Med
 1982
DOI: 10.1001/archpedi.1982.03970440057016
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T-Cell Dysfunction in Minimal-Change Nephrotic Syndrome of Childhood

Patricia Fodor1
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Cited by 75 publications

(40 citation statements)
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“…Serum SIRS, like urine SIRS, disappeared with steroid therapy. This finding is consistent with the hypothesis that SIRS mediates immune suppression in these patients, since normalization of immune responses has been reported to occur with induction of remission in MCNS (18). Cultured PBMC from patients with SRNS secreted SIRS without requiring activation by exogenous agents.…”
Section: Resultssupporting
confidence: 90%
“…This suggests that suppression of PFC responses by Con A or IFN is mediated primarily through the SIRS pathway. (16) and specific antibody titers (17), and suppression of delayed-type hypersensitivity to a variety of antigens ( 18). Increased suppressor cell activity ( 19) and suppressive activity of patient sera (20) In the present paper, serum SIRS activity was found in the same spectrum of diseases that manifest urinary excretion of SIRS.…”
Section: Resultssupporting
confidence: 50%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Serum SIRS, like urine SIRS, disappeared with steroid therapy. This finding is consistent with the hypothesis that SIRS mediates immune suppression in these patients, since normalization of immune responses has been reported to occur with induction of remission in MCNS (18). Cultured PBMC from patients with SRNS secreted SIRS without requiring activation by exogenous agents.…”
Section: Resultssupporting
confidence: 90%
“…This suggests that suppression of PFC responses by Con A or IFN is mediated primarily through the SIRS pathway. (16) and specific antibody titers (17), and suppression of delayed-type hypersensitivity to a variety of antigens ( 18). Increased suppressor cell activity ( 19) and suppressive activity of patient sera (20) In the present paper, serum SIRS activity was found in the same spectrum of diseases that manifest urinary excretion of SIRS.…”
Section: Resultssupporting
confidence: 50%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In the current study evidence of inhibition of normal lymphoblastogenesis was found in patients with MCNS during relapse in comparison to normal control subjects with the exception of chronic renal failure group. Such evidence was noticed previously by other workers [6][7][8][9][10] who found depressed lymphocytic response to mitogenic stimulation in young children with MCNS.…”
Section: Discussionsupporting
confidence: 86%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The expression of the CD25 antigen during relapses suggests an activation of CD4+ T cells and/or a recruitment of CD4+ CD25+ T cells endowed with T-suppressive functions. The possible recruitment of the CD4+ CD25+ T cell subset during relapses, seems to agree with some findings showing decreased T cell-mediated immunity and reduced lymphocyte response to mitogens [29], but these studies deserve to be revisited in light of new knowledge. Of note, the immune dysfunction is not restricted to CD4+ T cells.…”
Section: T Cell Signal Transduction In Mcnssupporting
confidence: 82%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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