2017
DOI: 10.18632/aging.101329
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Abstract: Polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (AMD) are prevalent age-related diseases characterized by exudative changes in the macula. Although they share anatomical and clinical similarities, they are also distinctly characterized by their own features, e.g. vascular abnormalities in PCV and drusen-mediated progression in neovascular AMD. PCV remains etiologically uncharacterized, and ongoing discussion is whether PCV and neovascular AMD share the same etiology or … Show more

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Cited by 20 publications
(21 citation statements)
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References 57 publications
(91 reference statements)
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“…; Subhi et al. ). In summary, there are in vivo and in vitro evidence to suggest that T‐lymphocytes may be functionally altered or impaired in patients with AMD.…”
Section: Discussionmentioning
confidence: 98%
“…; Subhi et al. ,b, ,b) which seem to play a complex intertwined role. Recent studies demonstrate that specific clinical features may be linked to specific immunological phenotypes in the systemic immunity (Singh et al.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…4 In eyes with geographic atrophy, the dark absence of FAF signal indicates the atrophic lesion. 14 Furthermore, natural killer cells are demonstrated to promote CNV formation, 15 and B cells from donors with AMD tend to be more sensitive to antigen-stimulation. Several studies of the natural history of GA find that a high degree of hyperautofluorescence in relation to the atrophic area is an indicator of fast progression.…”
Section: Introductionmentioning
confidence: 99%
“…In patients with neovascular AMD we previously found neutrophils with an altered activation state, 12 lower frequency of T-helper 1 cell 13 and aged phenotype of cytotoxic T-cells. 14 Furthermore, natural killer cells are demonstrated to promote CNV formation, 15 and B cells from donors with AMD tend to be more sensitive to antigen-stimulation. 16 Under normal conditions, microglia serves as the resident immune cells in the central nervous system (CNS) and in the retina, protecting the neurons from damage.…”
Section: Introductionmentioning
confidence: 99%