T and B Lymphocytes in the Aqueous Humor of Patients With Uveitis

Belfort, Rubens; Moura, Nayla C.; Mendes, Nelson F.

doi:10.1001/archopht.1982.01030030467019

Cited by 34 publications

(9 citation statements)

References 13 publications

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“…Other cells found in the aqueous humor of uveitis patients [23] include lymphocytes and monocytes. Types and subtypes of lymphocytes in the aqueous humor have also been studied in parasitic uveitis [24]. Reduced levels of antibodies that bind specifically to helper lymphocytes (OKT4 antibody) have been found in patients with acute uveitis [25].…”

Section: Cellular Eventscontrasting

confidence: 44%

“…Human uvea is able to produce leukotrienes [31]. LTB4 stimulates the proliferation of T-lymphocytes [32], the predominant immune cells in the anterior chamber of uveitis patients [24], while in the vitreous, Blymphocytes are more prevalent [33]. Sulfidopeptide leukotrienes have been implicated in anaphylactic reactions [34], and this hypersensitivity model (type I) seems to be important in the early phase of experimental autoimmune uveitis.…”

Section: Chemical Mediatorscontrasting

confidence: 40%

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Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

et al. 1990

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The cellular and biochemical events triggered by uveitis involve a complex array of cells and a heterogeneous network of mediators of intraocular inflammation. Resident cells are activated and inflammatory cells are recruited. Chemical mediators from the arachidonic acid cascade, prostaglandins, hydroxyeicosatetraenoic acids, and leukotrienes, are formed. Several of these metabolites are modulators of cellular functions, but when generated in sustained, excessive amounts, they contribute to enhanced vascular permeability and to the onset of pathophysiological responses. Another very active membrane-derived mediator is platelet-activating factor. This important mediator of immune and inflammatory responses may play a central role in uveitis due to cell priming, since interleukin-1, tumor necrosis factor, and other as yet unidentified mediators are also being generated. The concomitant accumulation of these networks of mediators in various parts of the uveal tract leads to spreading of the intraocular inflammatory response and cellular damage. At both early and late stages of uveitis, the generation of free radicals is also a major contributor to the impairment of function. Free radicals are generated in two distinct sites: in the oxidative burst of recruited white cells and in free radical formation and lipid peroxidation in resident cells. The identification of the cellular events that lead to the accumulation of networks of mediators of inflammation and their effects has important therapeutic implications in uveitis.

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Section: Cellular Eventscontrasting

confidence: 44%

Section: Chemical Mediatorscontrasting

confidence: 40%

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

et al. 1990

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“…The aqueous humor of Behcet's patients with uveitis has been shown to contain a higher number of T and B lymphocytes than normal [2,10]. Other studies have reported increased levels of immunoglobulin and im mune complexes in the sera of these patients [7,13,22].…”

Section: Introductionsupporting

confidence: 41%

Longitudinal Study of Serum Antibody Response to Bovine Corneal Protein (BCP 54) in Behçet’s Disease

Kong

Henley²,

Luntz³

1989

Ophthalmic Res

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Serum samples from a patient diagnosed as having active Behçet’s syndrome with iritis were evaluated by the enzyme-linked immunosorbent assay for antibodies against a purified bovine corneal protein, molecular weight 54,000 daltons (BCP 54). Significantly elevated antibody levels to BCP 54 were found in all serum samples collected over a 2-year period. Anti-BCP 54 antibody levels remained within a very narrow range, at least twofold higher than those of controls. In contrast, no antibody to retinal S antigen was detected. These results indicate the presence of specific anti-BCP 54 autoantibodies in sera from a Behçet’s patient and suggest that autoantibodies may play a role in the etiopathogenesis of uveitis.

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“…Some studies [29][30][31] reported that the immunological response in the ocular tissue of BD patients might be different from that in other parts of the body.…”

Section: Discussionmentioning

confidence: 50%

Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

et al. 2004

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Objective: The pathogenesis of Behçet’s disease (BD) may be related to excessive production of reactive oxygen species, activated neutrophils, and T lymphocytes. The goal of this prospective study was to investigate whether there is any relationship among the oxidant/antioxidant system and nitric oxide (NO) and malondialdehyde (MDA) levels in patients with BD and its subtypes: complete Behçet’s disease (CBD) and incomplete Behçet’s disease (ICBD), with or without ocular disease. Methods: Thirty-two patients and 26 age- and sex-matched healthy control subjects were evaluated for NO and MDA levels and antioxidant enzyme activities. The patients with BD were divided into two subgroups: those with and without ocular disease. Twelve patients with CBD and 4 patients with ICBD had ocular disease. The serum NO level was determined by Griess reaction. The MDA level was detected by thiobarbituric acid reaction. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in serum were analyzed with spectrophotometric methods. Results: Increased MDA levels but decreased GSH-Px activities in plasma were observed in BD patients with all subtypes, as compared with controls. Concerning the presence of ocular disease and the subtype (CBD or ICBD) compared with each other, there were no significant differences in MDA or NO serum levels and SOD or GSH-Px enzyme activities. Conclusions: Serum NO levels and SOD enzyme activities were not significantly changed in patients with BD and its subtypes; however, a remarkable decrease of GSH-Px enzyme activity and increase of MDA levels were found.

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T and B Lymphocytes in the Aqueous Humor of Patients With Uveitis

Cited by 34 publications

References 13 publications

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

Arachidonic acid cascade and platelet-activating factor in the network of eye inflammatory mediators: therapeutic implications in uveitis

Longitudinal Study of Serum Antibody Response to Bovine Corneal Protein (BCP 54) in Behçet’s Disease

Comparison of Serum Nitric Oxide, Malondialdehyde Levels, and Antioxidant Enzyme Activities in Behçet’s Disease with and without Ocular Disease

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