volume WCP2018, issue 0, PCL-8 2018
DOI: 10.1254/jpssuppl.wcp2018.0_cl-8
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Abstract: Conventional approaches to drug discovery and development have relied on identification of a molecular target, selection and refinement of a drug candidate and ultimately establishing its safety and efficacy in randomized trials. However, detection of such large average effects will be superseded by the need for information relevant to drug response at the individual level. Correspondingly, it has been appreciated that many drugs perturb wider biological networks than their canonical targets and that this may …

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