2020
DOI: 10.1167/iovs.61.10.47
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Abstract: Maintaining levels of nicotinamide adenine dinucleotide (NAD +), a coenzyme critical for cellular energetics and biosynthetic pathways, may be therapeutic in retinal disease because retinal NAD + levels decline during retinal damage and degeneration. The purpose of this study was to investigate whether systemic treatment with nicotinamide riboside (NR), a NAD + precursor that is orally deliverable and well-tolerated by humans, is protective in a mouse model of light-induced retinal degeneration. METHODS. Mice … Show more

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Cited by 14 publications
(10 citation statements)
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“…Prophylactic systemic treatment with NR, a NAD + precursor, is protective in several mouse models of neurodegenerative disease, including Alzheimer disease [ 56 ], Parkinson disease [ 57 ], and retinal degenerations [ 34 , 35 ]. We report here that systemic delivery of NR significantly increased NAD + levels in retinas of C57BL/6J and DBA/2J mice ( Figure 1 ), similar to findings we reported in BALB/c mice [ 34 , 35 ]. The difference between same-strain cohorts of levels of retinal NAD + is considerably different in the two strains, with an increase of ~17% for DBA/2J and an increase of ~205% for C57BL/6J mice.…”
Section: Discussionmentioning
confidence: 99%
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“…Prophylactic systemic treatment with NR, a NAD + precursor, is protective in several mouse models of neurodegenerative disease, including Alzheimer disease [ 56 ], Parkinson disease [ 57 ], and retinal degenerations [ 34 , 35 ]. We report here that systemic delivery of NR significantly increased NAD + levels in retinas of C57BL/6J and DBA/2J mice ( Figure 1 ), similar to findings we reported in BALB/c mice [ 34 , 35 ]. The difference between same-strain cohorts of levels of retinal NAD + is considerably different in the two strains, with an increase of ~17% for DBA/2J and an increase of ~205% for C57BL/6J mice.…”
Section: Discussionmentioning
confidence: 99%
“…Mice were euthanized after pERG measurement on the third day after ONC. Histologic procedures followed techniques as we described before [ 34 , 53 ]. Eyes were dehydrated, embedded in paraffin, and sectioned through the sagittal plane on a microtome at 5 µm increments.…”
Section: Methodsmentioning
confidence: 99%
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“…The supply with NAD + precursors, such as NMN and NR, represent an interesting approach to this condition. In a mouse model of light-induced acute retinal degeneration, Zhang and colleagues found that NR treatment prevented NAD + diminution following toxic light exposure (65). Maintenance of NAD + levels allowed continued activity of enzymes for which NAD + is a substrate, for example mitochondrial sirtuins, on which optimal activity relies NAD + -dependent retinal homeostasis (66).…”
Section: Nad + In Normal and Abnormal Function Of The Retinamentioning
confidence: 99%
“…In general, NR increases the clearance of autolysosomes through NAD + / SIRT1 signaling, thereby preventing doxorubicin cardiotoxicity [78]. There are also studies demonstrating the positive effect of NR on the models of retinal degeneration in BALB / c mice, which were injected with IP 1000 mg / kg of the drug [79].…”
Section: Effects Of Nr In Small Laboratory Animal Modelsmentioning
confidence: 99%