Systemic Tetracycline Treatment of Alkali-Induced Corneal Ulceration in Rabbits

The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats

“…Tetracycline antibiotics were reported to inhibit the corneal lysis caused by chemical injury to the eyes and other non-infectious corneal ulceration [45,46]. Several studies also reported that doxycycline promoted healing of the corneal epithelium [21,44,47].…”

The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats

“…Tetracycline antibiotics were reported to inhibit the corneal lysis caused by chemical injury to the eyes and other non-infectious corneal ulceration [45,46]. Several studies also reported that doxycycline promoted healing of the corneal epithelium [21,44,47].…”

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

“…These include the healing of non-infected corneal ulcers (Perry and Golub, 1985;Perry et al, 1986;Seedor et al, 1985), the inhibition of collagenase in the joint tissue and fluid of patients with rheumatoid arthritis (Greenwald et al, , 1987, the reduction of collagenolytic activity generated by melanoma tumor cells (Zucker et al, 1985), the inhibition of excessive bone resorption induced either by systemic or local factors , and, of course, the reduction of collagenolysis in the soft as well as hard tissues during periodontal disease (Golub et al, , 1985a. Consistent with this approach, Simonson et al (1986) recently demonstrated that minocycline and doxycycline (both tetracyclines), administered in vivo to rachitic rats, can suppress epiphyseal cartilage collagenase activity and restore some parameters of abnormal bone metabolism toward normal.…”

“…Numerous clinical studies (see "Introduction") as well as case reports (Fasciano and Fazio, 1981;Moskow, 1986) support the usefulness of tetracyclines as adjuncts in the treatment of periodontal diseases. A recent series of studies addressed the additional ability of these drugs to inhibit the activity of mammalian collagenases and the likelihood that this newly discovered property contributes significantly to their clinical efficacy in the management of periodontal and perhaps other diseases as well (Golub et al, , 1985aGomes et al, 1984;Zucker et al, 1985;Perry and Golub, 1985;Seedor et al, 1985;Greenwald et al, 1986Greenwald et al, , 1987.…”

Galardin Inhibits Collagen Degradation by Rabbit Keratocytes by Inhibiting the Activation of Pro-Matrix Metalloproteinases

“…EDTA, tetracycline, cysteine, and acetylcysteine suppress the activity of MMPs by nonspecifical interaction with zinc ions at the active sites, but these drugs failed as clinical treatments for corneal ulceration (Brown et al, 1970 ;Seedor et al, 1987). More potent MMP inhibitors, with a thiol group, have been investigated in animal studies (Burns et al, 1990a(Burns et al, , b, 1992.…”

The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats

“…Tetracycline antibiotics were reported to inhibit the corneal lysis caused by chemical injury to the eyes and other non-infectious corneal ulceration [45,46]. Several studies also reported that doxycycline promoted healing of the corneal epithelium [21,44,47].…”

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

“…These include the healing of non-infected corneal ulcers (Perry and Golub, 1985;Perry et al, 1986;Seedor et al, 1985), the inhibition of collagenase in the joint tissue and fluid of patients with rheumatoid arthritis (Greenwald et al, , 1987, the reduction of collagenolytic activity generated by melanoma tumor cells (Zucker et al, 1985), the inhibition of excessive bone resorption induced either by systemic or local factors , and, of course, the reduction of collagenolysis in the soft as well as hard tissues during periodontal disease (Golub et al, , 1985a. Consistent with this approach, Simonson et al (1986) recently demonstrated that minocycline and doxycycline (both tetracyclines), administered in vivo to rachitic rats, can suppress epiphyseal cartilage collagenase activity and restore some parameters of abnormal bone metabolism toward normal.…”

“…Numerous clinical studies (see "Introduction") as well as case reports (Fasciano and Fazio, 1981;Moskow, 1986) support the usefulness of tetracyclines as adjuncts in the treatment of periodontal diseases. A recent series of studies addressed the additional ability of these drugs to inhibit the activity of mammalian collagenases and the likelihood that this newly discovered property contributes significantly to their clinical efficacy in the management of periodontal and perhaps other diseases as well (Golub et al, , 1985aGomes et al, 1984;Zucker et al, 1985;Perry and Golub, 1985;Seedor et al, 1985;Greenwald et al, 1986Greenwald et al, , 1987.…”

Galardin Inhibits Collagen Degradation by Rabbit Keratocytes by Inhibiting the Activation of Pro-Matrix Metalloproteinases

“…EDTA, tetracycline, cysteine, and acetylcysteine suppress the activity of MMPs by nonspecifical interaction with zinc ions at the active sites, but these drugs failed as clinical treatments for corneal ulceration (Brown et al, 1970 ;Seedor et al, 1987). More potent MMP inhibitors, with a thiol group, have been investigated in animal studies (Burns et al, 1990a(Burns et al, , b, 1992.…”

The effect of doxycycline temperature-sensitive hydrogel on inhibiting the corneal neovascularization induced by BFGF in rats

“…Tetracycline antibiotics were reported to inhibit the corneal lysis caused by chemical injury to the eyes and other non-infectious corneal ulceration [45,46]. Several studies also reported that doxycycline promoted healing of the corneal epithelium [21,44,47].…”

A Non-antibacterial Chemically-modified Tetracycline Inhibits Mammalian Collagenase Activity

“…These include the healing of non-infected corneal ulcers (Perry and Golub, 1985;Perry et al, 1986;Seedor et al, 1985), the inhibition of collagenase in the joint tissue and fluid of patients with rheumatoid arthritis (Greenwald et al, , 1987, the reduction of collagenolytic activity generated by melanoma tumor cells (Zucker et al, 1985), the inhibition of excessive bone resorption induced either by systemic or local factors , and, of course, the reduction of collagenolysis in the soft as well as hard tissues during periodontal disease (Golub et al, , 1985a. Consistent with this approach, Simonson et al (1986) recently demonstrated that minocycline and doxycycline (both tetracyclines), administered in vivo to rachitic rats, can suppress epiphyseal cartilage collagenase activity and restore some parameters of abnormal bone metabolism toward normal.…”

“…Numerous clinical studies (see "Introduction") as well as case reports (Fasciano and Fazio, 1981;Moskow, 1986) support the usefulness of tetracyclines as adjuncts in the treatment of periodontal diseases. A recent series of studies addressed the additional ability of these drugs to inhibit the activity of mammalian collagenases and the likelihood that this newly discovered property contributes significantly to their clinical efficacy in the management of periodontal and perhaps other diseases as well (Golub et al, , 1985aGomes et al, 1984;Zucker et al, 1985;Perry and Golub, 1985;Seedor et al, 1985;Greenwald et al, 1986Greenwald et al, , 1987.…”

Galardin Inhibits Collagen Degradation by Rabbit Keratocytes by Inhibiting the Activation of Pro-Matrix Metalloproteinases

“…EDTA, tetracycline, cysteine, and acetylcysteine suppress the activity of MMPs by nonspecifical interaction with zinc ions at the active sites, but these drugs failed as clinical treatments for corneal ulceration (Brown et al, 1970 ;Seedor et al, 1987). More potent MMP inhibitors, with a thiol group, have been investigated in animal studies (Burns et al, 1990a(Burns et al, , b, 1992.…”