Systemic Steroids and Ocular Fluid Dynamics. Ii

Abstract

In 59 patients treated with long-term systemic steroids, 3 distinct groups with different levels of sensitivity to the steroid effect on intraocular pressure and fluid dynamics could be distinguished by a topical dexamethasone test. The percental distribution of the 3 pressure-rise-level groups and the mean pressure change within each group were equal to those found in a normal population not pre-treated with systemic steroids. Whereas only 16O/o of the patients with steroid pressures lower than 18 mmHg were sensitive to topically applied dexamethasone, 70 O / o of the patients responding with intermediate and high pressure rise to topical dexamethasone had systemic steroid pressures in the range of 18 mmHg or more. The effect of systemic steroids on ocular pressure apparently does not affect the magnitude of pressure elevation induced in the positive responders by topical dexamethasone. Intergroup analysis of the steroid group classified according to dosage and duration of treatment proved that differences in mean values of applanation pressure between the subgroups depend solely on the proportion of positive and negative steroid responders within the subgroups.The mean systemic steroid C value in the group of patients responding to topical steroid with pressure elevation of 6 mmHg or more was only 10 O / o lower than the same value in patients regarded as non-responders by the

Impact of chronic corticosteroid administration on intraocular pressure in renal transplant recipients

“…Topical application of corticosteroid preparations appears to cause more profound changes in IOP than has systemic corticosteroid therapy. Godez et al (10) reported that the increase in IOP produced by systemic steroids was only 60% of that seen with topical steroid preparations. This disparity could be due to underlying differences in the pathophysiology of topical versus systemic corticosteroid‐induced IOP elevations.…”

Impact of chronic corticosteroid administration on intraocular pressure in renal transplant recipients

“…Topical application of corticosteroid preparations appears to cause more profound changes in IOP than has systemic corticosteroid therapy. Godez et al (10) reported that the increase in IOP produced by systemic steroids was only 60% of that seen with topical steroid preparations. This disparity could be due to underlying differences in the pathophysiology of topical versus systemic corticosteroid‐induced IOP elevations.…”

Drug-induced (toxic) glaucoma

“…Systemic corticosteroids are also prescribed for many auto-immune diseases and local injections of steroids are often used to manage pain in rheumatological or orthopedic diseases. Although systemic use of steroids is less likely to cause glaucoma, if it does occur, it is not dose or duration dependent 5 .…”

Influence of Long-term Oral Steroid Intake on Glaucoma and Ocular Hypertension

“…의존적 관계가 있다고 주장하였다. 다만, Godel et al24 에 따 르면 안압상승과 스테로이드 농도, 복용 기간은 서로 관계 가 없다고 보고하였다. 즉, 경구 스테로이드를 장기적으로 복용할 시 안압상승에 어떠한 영향을 미치는지에 대해 확 실한 결론은 현재 없다.…”

Impact of chronic corticosteroid administration on intraocular pressure in renal transplant recipients

“…Topical application of corticosteroid preparations appears to cause more profound changes in IOP than has systemic corticosteroid therapy. Godez et al (10) reported that the increase in IOP produced by systemic steroids was only 60% of that seen with topical steroid preparations. This disparity could be due to underlying differences in the pathophysiology of topical versus systemic corticosteroid‐induced IOP elevations.…”

Drug-induced (toxic) glaucoma

“…Systemic corticosteroids are also prescribed for many auto-immune diseases and local injections of steroids are often used to manage pain in rheumatological or orthopedic diseases. Although systemic use of steroids is less likely to cause glaucoma, if it does occur, it is not dose or duration dependent 5 .…”

Influence of Long-term Oral Steroid Intake on Glaucoma and Ocular Hypertension

“…의존적 관계가 있다고 주장하였다. 다만, Godel et al24 에 따 르면 안압상승과 스테로이드 농도, 복용 기간은 서로 관계 가 없다고 보고하였다. 즉, 경구 스테로이드를 장기적으로 복용할 시 안압상승에 어떠한 영향을 미치는지에 대해 확 실한 결론은 현재 없다.…”

Impact of chronic corticosteroid administration on intraocular pressure in renal transplant recipients

“…Topical application of corticosteroid preparations appears to cause more profound changes in IOP than has systemic corticosteroid therapy. Godez et al (10) reported that the increase in IOP produced by systemic steroids was only 60% of that seen with topical steroid preparations. This disparity could be due to underlying differences in the pathophysiology of topical versus systemic corticosteroid‐induced IOP elevations.…”

Drug-induced (toxic) glaucoma

“…Systemic corticosteroids are also prescribed for many auto-immune diseases and local injections of steroids are often used to manage pain in rheumatological or orthopedic diseases. Although systemic use of steroids is less likely to cause glaucoma, if it does occur, it is not dose or duration dependent 5 .…”

Influence of Long-term Oral Steroid Intake on Glaucoma and Ocular Hypertension

“…의존적 관계가 있다고 주장하였다. 다만, Godel et al24 에 따 르면 안압상승과 스테로이드 농도, 복용 기간은 서로 관계 가 없다고 보고하였다. 즉, 경구 스테로이드를 장기적으로 복용할 시 안압상승에 어떠한 영향을 미치는지에 대해 확 실한 결론은 현재 없다.…”