Systemic rotavirus infection

Ramig, Robert F.

doi:10.1586/14787210.5.4.591

Cited by 49 publications

(72 citation statements)

References 103 publications

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“…Rotavirus infection is usually localized to the intestine; however, recent studies reported antigenemia or viremia in children with rotavirus diarrhea (11,12,17,18,90). Rarely, involvement of extraintestinal sites, including the respiratory tract, liver, kidney, lymph nodes, and central nervous system, has been reported (54,55,64,70).…”

Section: Introductionmentioning

confidence: 99%

Rotavirus Vaccines: an Overview

2008

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SUMMARY Rotavirus infection is the most common cause of severe diarrhea disease in infants and young children worldwide and continues to have a major global impact on childhood morbidity and mortality. Vaccination is the only control measure likely to have a significant impact on the incidence of severe dehydrating rotavirus disease. In 1999, a highly efficacious rotavirus vaccine licensed in the United States, RotaShield, was withdrawn from the market after 14 months because of its association with intussusception. Two new live, oral, attenuated rotavirus vaccines were licensed in 2006: the pentavalent bovine-human reassortant vaccine (RotaTeq) and the monovalent human rotavirus vaccine (Rotarix). Both vaccines have demonstrated very good safety and efficacy profiles in large clinical trials in western industrialized countries and in Latin America. Careful surveillance has not revealed any increased risk of intussusception in the vaccinated groups with either vaccine. The new rotavirus vaccines are now introduced for routine use in a number of industrialized and developing countries. These new safe and effective rotavirus vaccines offer the best hope of reducing the toll of acute rotavirus gastroenteritis in both developed and developing countries.

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Section: Introductionmentioning

confidence: 99%

Rotavirus Vaccines: an Overview

2008

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“…[94] Rotavirus infections rarely cause other complications and for a well managed child the prognosis is excellent. [95] …”

Section: Markers Of Protectionmentioning

confidence: 99%

Rotavirus

Beards¹

2017

Wiki J Med

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Rotavirus is the most common cause of diarrhoeal disease among infants and young children. [1] It is a genus of double-stranded RNA viruses in the family Reoviridae. Nearly every child in the world is infected with rotavirus at least once by the age of five. [2] Immunity develops with each infection, so subsequent infections are less severe; adults are rarely affected. [3] There are eight species of this virus, referred to as A, B, C, D, E, F, G and H. Rotavirus A, the most common species, causes more than 90% of rotavirus infections in humans.The virus is transmitted by the faecal-oral route. It infects and damages the cells that line the small intestine and causes gastroenteritis (which is often called "stomach flu" despite having no relation to influenza). Although rotavirus was discovered in 1973 by Ruth Bishop and her colleagues by electron micrograph images [4] and accounts for approximately one third of hospitalisations for severe diarrhoea in infants and children, [5] its importance has historically been underestimated within the public health community, particularly in developing countries. [6] In addition to its impact on human health, rotavirus also infects animals, and is a pathogen of livestock. [7] Rotavirus is usually an easily managed disease of childhood, but in 2013, rotavirus caused 37 percent of deaths of children from diarrhoea and 215,000 deaths worldwide, [8] and almost two million more become severely ill. [6] Most of these deaths occurred in developing countries. [9] In the United States, before initiation of the rotavirus vaccination programme, rotavirus caused about 2.7 million cases of severe gastroenteritis in children, almost 60,000 hospitalisations, and around 37 deaths each year. [10] Following rotavirus vaccine introduction in the United States, hospitalisation rates have fallen significantly. [11][12] Public health campaigns to combat rotavirus focus on providing oral rehydration therapy for infected children and vaccination to prevent the disease. [13] The incidence and severity of rotavirus infections has declined significantly in countries that have added rotavirus vaccine to their routine childhood immunisation policies. [14][15] [16] Virology Types of rotavirusThere are eight species of rotavirus, referred to as groups A, B, C, D, E, F, G, and H. [17] Humans are primarily infected by species A, B and C, most commonly by species A. A-E species cause disease in other animals, [18] species E and H in pigs, and D, F and G in birds.[19] [20] Within rotavirus A there are different strains, called serotypes.[21] As with influenza virus, a dual classification system is used based on two proteins on the surface of the virus. The glycoprotein VP7 defines the G serotypes and the protease-sensitive protein VP4 defines P serotypes.[22] Because the two genes that determine G-types and P-types can be passed on separately to progeny viruses, different combinations are found.[22] A whole genome genotyping system has been established for group A rotaviruses, which has been used to ...

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“…It has 102 been reported that group A rotavirus was detected in some tissues of domestic and 103 experimental animals (Ramig, 2007). To assess the infection of the bat by LUS12-14, we 104 extracted RNA from the spleen, lung, kidney and liver tissues of the bat in which 105 LUS12-14 was detected in the intestinal contents.…”

Section: (Rhinolophus Simulator) 83mentioning

confidence: 99%

Multi-reassortant G3P[3] group A rotavirus in a horseshoe bat in Zambia

Sasaki

Orba

Sasaki

et al. 2016

Journal of General Virology

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33Group A rotavirus is a major cause of diarrhoea in humans, especially in young 34 children. Bats also harbour group A rotaviruses, but the genetic backgrounds of bat 35 rotavirus strains are usually distinct from those of human rotavirus strains. We identified 36 a new strain of group A rotavirus in the intestinal contents of a horseshoe bat in Zambia. 37Whole genome sequencing revealed that the identified virus, named 38 RVA/Bat-wt/ZMB/LUS12-14/2012/G3P [3], possessed the genotype constellation 39

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Systemic rotavirus infection

Cited by 49 publications

References 103 publications

Rotavirus Vaccines: an Overview

Rotavirus Vaccines: an Overview

Rotavirus

Multi-reassortant G3P[3] group A rotavirus in a horseshoe bat in Zambia

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