2015
DOI: 10.18632/aging.100819
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Abstract: This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing pr… Show more

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Cited by 52 publications
(59 citation statements)
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References 102 publications
(147 reference statements)
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“…For example, TGFβ family members interfere with stem cell function and have been implicated in age-related progenitor dysfunction (Carlson and others 2009; Conboy and others 2015). A member of the TGFβ superfamily, activin A, increases in plasma with aging, and is secreted by senescent adipose progenitor cells.…”
Section: Treating Age-related Adipose Tissue Dysfunctionmentioning
confidence: 99%
“…For example, TGFβ family members interfere with stem cell function and have been implicated in age-related progenitor dysfunction (Carlson and others 2009; Conboy and others 2015). A member of the TGFβ superfamily, activin A, increases in plasma with aging, and is secreted by senescent adipose progenitor cells.…”
Section: Treating Age-related Adipose Tissue Dysfunctionmentioning
confidence: 99%
“…One way to increase healthy longevity would be to rejuvenate the regenerative and repair capacity of aged tissues. Published work suggests restoring the circulatory environment of aged tissues back to a productive, young, composition may help to rapidly and broadly enhance the maintenance and repair of multiple old organs, combat degeneration and extend health span12345678.…”
mentioning
confidence: 99%
“…For example, old animals with young partners have, through the shared circulation, continuous access to the young organs, which regulate metabolic homeostasis, wound clearance and inflammation, and provide blood oxygenation to the animals35. Old mice attached to young animals also benefit from environmental enrichment and youthful pheromones, which may play a role in neuronal plasticity and neurogenesis910.…”
mentioning
confidence: 99%
“…The technique of heterochronic parabiosis, where two animals of different ages are joined together surgically to create shared circulatory system, illustrates that factors in young blood can rejuvenate aged stem cells from muscle, liver and brain in mice (Conboy et al, 2005). The administration of young blood improves also cognitive function and rejuvenates synaptic plasticity in old mice (Villeda et al, 2014), supporting the notion that cellular aging not only depends on intrinsic factors, such as DNA damage and ROS accumulation, but also relies on extrinsic factors (Conboy et al, 2015). To date, GDF11 (although very controversial) (Loffredo et al, 2013), oxytocin (Elabd et al, 2014), klotho (Kuro-o et al, 1997) have been described as “rejuvenation” circulating factors and it remains to be seen whether they can provide a youthful phenotype in the entire aged animal.…”
Section: Direct Anti-aging and Rejuvenating Effectsmentioning
confidence: 77%