Systemic lupus erythematosus presenting with neurological disorders

Tola, Maria Rosaria; Granieri, Enrico; Caniatti, Luisa; Paolino, E.; Monetti, C; Dovigo, L; Scolozzi, R; Bastiani, P. De; Carreras, M

doi:10.1007/bf00862972

Cited by 58 publications

(23 citation statements)

References 24 publications

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“…In SLE, support for the direct pathogenicity of anti-DNA antibodies derives from the close correlation between disease activity, particularly lupus nephritis, and levels of anti-DNA reactivity in serum, as well as from the ability of anti-DNA antibodies to induce disease in severe combined immunodeficient-and recombination-activating gene-1-deficient mice (38). Intriguingly, an estimated 40-70% of patients with SLE develop CNS involvement, including optic neuritis (39)(40)(41)(42)(43). Indeed, the term ''lupoid sclerosis'' is used to describe a patient presenting with clinical features of both MS and SLE.…”

Section: Resultsmentioning

confidence: 99%

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis

Williamson

Burgoon

Owens

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of unknown cause that afflicts the central nervous system. MS is typified by a highly clonally restricted antigen-driven antibody response that is confined largely to the central nervous system. The major antigenic targets of this response and the role of antibody in disease pathogenesis remain unclear. To help resolve these issues, we cloned the IgG repertoire directly from active plaque and periplaque regions in MS brain and from B cells recovered from the cerebrospinal fluid of a patient with MS with subacute disease. We found that high-affinity anti-DNA antibodies are a major component of the intrathecal IgG response in the patients with MS that we studied. Furthermore, we show DNA-specific monoclonal antibodies rescued from two subjects with MS as well as a DNA-specific antibody rescued from an individual suffering from systemic lupus erythematosus bound efficiently to the surface of neuronal cells and oligodendrocytes. For two of these antibodies, cell-surface recognition was DNA dependent. Our findings indicate that anti-DNA antibodies may promote important neuropathologic mechanisms in chronic inflammatory disorders, such as MS and systemic lupus erythematosus.

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Section: Resultsmentioning

confidence: 99%

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis

Williamson

Burgoon

Owens

et al. 2001

Proc. Natl. Acad. Sci. U.S.A.

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“…The association between the anti-DNA autoimmunity and the anti-GluR3 peptide autoimmunity is unclear, as is the potential contribution of anti-DNA autoreactivity to neurological dysfunction and epilepsy. However, epileptic seizures are known to occur in some SLE patients bearing high levels of anti-DNA antibodies [34][35][36][37].…”

Section: Discussionmentioning

confidence: 99%

Autoimmunity to the Glutamate Receptor in Mice— A Model for Rasmussen's Encephalitis?

Levite

Hermelin

1999

Journal of Autoimmunity

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“…Central nervous system (CNS) involvement in systemic lupus erythematosus (SLE) is reported to occur with varying prevalencies in different studies (McCune and Golbus, 1988;Omdal et al, 1989;Van Dam, 1991 ;Furtrell et al, 1992;Tola et a/., 1992;Wecking, 1993). This most likely reflects differences in patient selection and a lack of uniformity in diagnostic criteria for CNS involvement (McCune and Golbus, 1988;Futrell et al, 1992).…”

Section: Introductionmentioning

confidence: 94%

Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients

Waterloo

Omdal

Mellgren

et al. 1997

Euro J of Neurology

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A comprehensive battery of neuropsychological tests sampling a wide range of cognitive functions was administrated to 36 patients with systemic lupus erythematosus (SLE), and a control group consisting of 31 patients with persistent symptoms after whiplash injury. Our results demonstrated significant group differences and suggest that cognitive dysfunction is common in SLE and that there are significant abnormalities in the SLE group compared to chronic illness of non-immunological nature. Considerable variability occurred in the neuropsychological profiles for SLE patients. No significant association was found between cognitive dysfunction and use of corticosteroids, except for the two neuropsychological tests Digit span and Seashore rhythm test. Associations were not found between cognitive dysfunction and depression either, except for the Seashore rhythm test. These findings indicate that cognitive dysfunction in SLE reflects CNS involvement, rather than coexisting emotional disturbance. No significant cognitive impairment was found in the whiplash group. However, our results indicate depressed mood among the whiplash group.

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Systemic lupus erythematosus presenting with neurological disorders

Cited by 58 publications

References 24 publications

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis

Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis

Autoimmunity to the Glutamate Receptor in Mice— A Model for Rasmussen's Encephalitis?

Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients

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