Systemic lupus erythematosus and vaccination

Millet, Arnaud; Decaux, Olivier; Perlat, Antoinette; Grosbois, B.; Jégo, Patrick

doi:10.1016/j.ejim.2008.07.017

Cited by 33 publications

(32 citation statements)

References 42 publications

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“…Using techniques similar to those employed in this study, we found that ϳ20% of isolated rMAbs from subjects immunized with trivalent inactivated influenza vaccine were polyreactive (B. F. Haynes, unpublished data). Vaccinations have been rarely reported to reactivate autoimmune disease (35); however, most evidence supports the safety of killed or recombinant vaccines in autoimmune disease patients (1,7,32,52). In cases where it is observed, autoantibody increases following vaccination have been reported to have no clinical consequences (1,52).…”

Section: Discussionmentioning

confidence: 99%

HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

Moody

Yates

Amos

et al. 2012

J Virol

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h Most antibodies that broadly neutralize HIV-1 are highly somatically mutated in antibody clonal lineages that persist over time. Here, we describe the analysis of human antibodies induced during an HIV-1 vaccine trial (GSK PRO HIV-002) that used the clade B envelope (Env) gp120 of clone W6.1D (gp120 W6.1D ). Using dual-color antigen-specific sorting, we isolated Env-specific human monoclonal antibodies (MAbs) and studied the clonal persistence of antibodies in the setting of HIV-1 Env vaccination. We found evidence of V H somatic mutation induced by the vaccine but only to a modest level (3.8% ؎ 0.5%; range 0 to 8.2%). Analysis of 34 HIV-1-reactive MAbs recovered over four immunizations revealed evidence of both sequential recruitment of naïve B cells and restimulation of previously recruited memory B cells. These recombinant antibodies recapitulated the anti-HIV-1 activity of participant serum including pseudovirus neutralization and antibody-dependent cell-mediated cytotoxicity (ADCC). One antibody (3491) demonstrated a change in specificity following somatic mutation with binding of the inferred unmutated ancestor to a linear C2 peptide while the mutated antibody reacted only with a conformational epitope in gp120 Env. Thus, gp120 W6.1D was strongly immunogenic but over four immunizations induced levels of affinity maturation below that of broadly neutralizing MAbs. Improved vaccination strategies will be needed to drive persistent stimulation of antibody clonal lineages to induce affinity maturation that results in highly mutated HIV-1 Env-reactive antibodies.

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Section: Discussionmentioning

confidence: 99%

HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

Moody

Yates

Amos

et al. 2012

J Virol

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“…In some patients (not in all) with some autoimmune diseases (rheumatoid arthritis, type I diabetes, systemic lupus erithematosus, and multiple sclerosis, but not in other diseases), treated with some (not all) immunosuppressive drugs immunogenicity of some (not all) vaccines is lower that in controls, although (this is fundamental for the practice) protective (27,28). In addition, response is better in children, at least for some vaccines, in children with some ADs (chronic arthritis).…”

Section: Are Vaccines Safe In Patients With Autoimmune Diseases?mentioning

confidence: 99%

“…Risk is now higher because of the introduction of biologics in the management of many autoimmune diseases. Thus sound data on safety, immunogenicity, and efficacy are needed to optimize immunization practices and vaccination coverage in these patients who have a lower vaccination rate than healthy individuals in spite of the vital importance of preventing immunocompromized patients from infectious diseases (11,27,28).…”

Section: Are Vaccines Safe In Patients With Autoimmune Diseases?mentioning

confidence: 99%

Vaccines and Autoimmunity

Martino

Chiappini

Galli

2013

Int J Immunopathol Pharmacol

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Vaccines have eradicated or controlled many infectious diseases, saving each year millions of lives and quality of life of many other millions of people. In spite of the success of vaccines over the last two centuries, parents (and also some health care workers) gloss over the devastating consequences of diseases, which are now avoided thanks to vaccines, and direct their attention to possible negative effects of immunization. Three immunological objections are raised: vaccines cause antigenic overload, natural immunity is safer and better than vaccine-induced immunity, and vaccines induce autoimmunity. The last point is examined in this review. Theoretically, vaccines could trigger autoimmunity by means of cytokine production, anti-idiotypic network, expression of human histocompatibility leukocyte antigens, modification of surface antigens and induction of novel antigens, molecular mimicry, bystander activation, epitope spreading, and polyclonal activation of B cells. There is strong evidence that none of these mechanisms is really effective in causing autoimmune diseases. Vaccines are not a source of autoimmune diseases. By contrast, absolute evidence exists that infectious agents can trigger autoimmune mechanisms and that they do cause autoimmune diseases.

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“…While potentially useful in the generation of research hypotheses, these proposed is not reflected by clinical studies of vaccine safety in SLE. One systematic review (67) found vaccination to be safe in SLE, with the well-known exception of administering live vaccines in the setting of immunosuppression (which is generally contraindicated), although immunization may achieve a reduced level of protection in deeply immunosuppressed persons, such as people undergoing immunosuppressive treatment for AID, particularly by potent anti-cytokine agents. Another recent review confirmed infections as important triggers of exacerbations in SLE and found vaccination to be safe and effective in SLE patients (68).…”

Section: "Autoimmune/inflammatory Syndrome Induced By Adjuvants"mentioning

confidence: 99%

Vaccination and Autoimmune Phenomena

Janković

2017

CEJP

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Systemic lupus erythematosus and vaccination

Cited by 33 publications

References 42 publications

HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

HIV-1 gp120 Vaccine Induces Affinity Maturation in both New and Persistent Antibody Clonal Lineages

Vaccines and Autoimmunity

Vaccination and Autoimmune Phenomena

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