Systemic inflammatory response syndrome outcome in surgical patients

Singh, Simrandeep; Singh, Pradeep; Singh, Gurjit

doi:10.1007/s12262-009-0062-z

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…Criteria for SIRS was kept as: Two or more of the following variables 2 1. Pulse rate (PR): >90beats/min 2.…”

Section: Materials and Methods:-mentioning

confidence: 99%

“…White blood cell (WBC) greater than 12,000/µl or less than 4000/µl or greater than 10% immature (band) forms. 2 The SIRS includes two general phrases-An acute pro inflammatory state resulting from innate immune system recognition of ligands and An anti-inflammatory phase that may serve to modulate pro inflammatory phase.Under normal conditions, these coordinated responses direct a return to homeostasis. 3…”

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confidence: 99%

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To Study the Incidence of Systemic Inflammatory Response Syndrome (Sirs) Outcome in Patients Undergoing Elective or Emergency Surgeries

Singla¹,

Garg²,

Sharma³

2020

IJAR

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Systemic Inflammatory Response Syndrome, Multi Organ Dysfunction Syndrome (MODS), Multi Organ Failure (MOF) Background: Systemic inflammatory response syndrome is a simple bed side tool to assess the severity of the patient's disease process which gives the approximate idea about the outcome of the surgical patients. Mortality rate increased progressively as the severity of systemic inflammatory response increased.This study investigated the Incidence of Systemic inflammatory response syndrome (SIRS) outcome in patients undergoing elective or emergency surgeries. Objectives: To study the Incidence of Systemic inflammatory response syndrome (SIRS) outcome in patients undergoing elective or emergency surgeries Methods: This was a prospective study conducted over a period of 2 years at GMC Amritsar. The total of 50 patients undergoing surgical procedures was studied. They were followed up till date of termination with daily SIRS monitoring, development of MODS and MOF.Statistical analysis was based on simple percentages among related variables. Results: Overall incidence of SIRS was 74%. Incidence of SIRS was more in patients undergoing emergency surgery than the patient who underwent elective surgery (43.47%). The difference was statistically significant. (p<0.05). Average SIRS score was higher in emergency surgery group than elective surgery group. Conclusion: SIRS is key pathogenic factor in postoperative morbidity which gives the approximate idea about the outcome of the surgical patients.

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“…Criteria for SIRS was kept as: Two or more of the following variables 2 1. Pulse rate (PR): >90beats/min 2.…”

Section: Materials and Methods:-mentioning

confidence: 99%

mentioning

confidence: 99%

To Study the Incidence of Systemic Inflammatory Response Syndrome (Sirs) Outcome in Patients Undergoing Elective or Emergency Surgeries

Singla¹,

Garg²,

Sharma³

2020

IJAR

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“…Not only microbes but also trauma activate innate immunity causing both pro- and anti-inflammatory responses 13 and similar activation has been shown after elective surgery. 14 Over time the anti-inflammatory response might become more dominating resulting in a pronounced decrease in T-cell function, 15–17 which can be referred to as posttraumatic immunosuppression or trauma-induced immune deficiency syndrome (TIDS). In patients with neurotrauma, innate and adaptive immunity may be globally downregulated to prevent post-injury autoimmune reactions.…”

Section: Introductionmentioning

confidence: 99%

Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma; is the B-cell response preserved?

Hedberg

Pauksens

Enblad

et al. 2022

Human Vaccines & Immunotherapeutics

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Background After trauma and central nervous system (CNS) injury, trauma-induced immune deficiency syndrome (TIDS) and CNS injury-induced immune deficiency syndrome (CIDS) may negatively affect responses to T-cell-dependent vaccines, such as pneumococcal conjugate vaccine (PCV) recommended after basilar fracture. This study (NCT02806284) aimed to investigate whether there after neurotrauma is a correlation between T-cell-dependent and independent vaccine responses and, thus, if B-cell activity is similarly depressed and whether the T-cell-dependent response is possible to predict. Methods Adult patients with basilar fracture (n = 33) and those undergoing pituitary gland surgery (n = 23) were within 10 days vaccinated with a T-cell-dependent vaccine against Haemophilus influenzae type b (Hib) and a T-cell-independent pneumococcal polysaccharide vaccine (PPSV). Samples reflecting the systemic inflammatory response and pre- and post-vaccination antibody levels after 3–6 weeks against Hib and PPSV were collected and determined by enzyme immunoassays. Results High and significant correlations were detected in the responses to different pneumococcal serotypes, but none between the Hib and PPSV responses. No differences in trauma scores, C-reactive protein, IL-6, IL-10, pentraxin 3, fractalkine or calprotectin plasma concentrations or in ex vivo TNF-α, IL-6 or IL-10 responses to endotoxin were found between Hib vaccination responders and non-responders. Conclusions There was no correlation between the pneumococcal responses and that to Hib, indicating that B-cell function is not similarly depressed as T-cell function. Grading of the trauma or parameters reflecting the innate immune response could not predict the T-cell-dependent vaccine response. There is a need of further studies evaluating the vaccine response after neurotrauma.

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Spatial analysis and identification of environmental risk factors affecting the distribution of Indoplanorbis and Lymnaea species in semi-arid and irrigated areas of Haryana, India

Sangwan

Jackson

Glanville

et al. 2016

Parasite Epidemiology and Control

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Fasciolosis, amphistomosis and schistosomosis, transmitted by the freshwater snail species Indoplanorbis and Lymnaea, are important snail-borne diseases in India as they affect the entire spectrum of domestic animals causing substantial mortality and economic loss. Identifying any heterogeneity in the spatial distribution of these snail-borne diseases will allow for targeted disease control and efficient use of resources. The objectives of this study were threefold: (i) to describe and explore the spatial distribution of Indoplanorbis and Lymnaea in Rohtak and Jhajjar districts of Haryana, India (ii) to identify factors associated with occurrence of these freshwater snail species and (iii) to produce a map showing the predicted risk of occurrence of Lymnaea and Indoplanorbis spp. in the study area. Snails were collected from water bodies of 99 settlements out of a total of 453 in the study area. Kernel smoothing was used to generate a kernel ratio map while Kulldorff's spatial scan statistic was used to detect clusters of settlements with a high/low risk. Multivariable logistic regression showed that snails were almost ten times more likely to be present in rice-growing areas than in those not growing rice (OR 9.24) and that snails were less likely to be present with each 1 km increase in distance from a canal (OR 0.86). The regression model was used to produce a map illustrating the predicted risk of snail occurrence. Since the distribution of vector snails mirrors the distribution of snail-borne parasitic diseases, such spatial analysis helps to determine the relative risk of snail-infestation as well as snail-borne diseases' distribution and planning of control activities.

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Systemic inflammatory response syndrome outcome in surgical patients

Abstract: Early detection of SIRS helps us to prevent multiple organ dysfunction syndrome (MODS)/MOF, leading to lesser hospital stay and better outcome.

Cited by 5 publications

References 16 publications

To Study the Incidence of Systemic Inflammatory Response Syndrome (Sirs) Outcome in Patients Undergoing Elective or Emergency Surgeries

To Study the Incidence of Systemic Inflammatory Response Syndrome (Sirs) Outcome in Patients Undergoing Elective or Emergency Surgeries

Relationship between T-cell-dependent and T-cell-independent vaccines after neurotrauma; is the B-cell response preserved?

Spatial analysis and identification of environmental risk factors affecting the distribution of Indoplanorbis and Lymnaea species in semi-arid and irrigated areas of Haryana, India

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