Systemic Immune-Inflammatory Index Is Associated with Residual SYNTAX Score in Patients with ST-Segment Elevation Myocardial Infarction

Abstract

Background: Systemic immune-inflammatory index (platelet count × neutrophil–lymphocyte ratio) is a new marker that predicts adverse clinical outcomes in coronary artery diseases. Our aim was to investigate the relationship between the systemic immune-inflammatory index and residual SYNTAX score in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Methods: In this retrospective study, 518 consecutive patients who underwent primary percutaneous coronary intervention (PCI) with the diagnosis of ST-segment elevation myocardial infarction were analyzed. The severity of coronary artery diseases was determined by residual SYNTAX score. In the receiver operating characteristic curve analysis, systemic immune-inflammatory index with an optimal threshold value of 1025.1 could detect the presence of a high residual SYNTAX score; the patients were divided into 2 groups as low (326) and high (192) according to the threshold value. In addition, binary multiple logistic regression analysis methods were used to evaluate independent predictors of high residual SYNTAX score. Results: In binary multiple logistic regression analysis, systemic immune-inflammatory index [odds ratio = 6.910; 95% CI = 4.203-11.360; P < .001] was an independent predictor of high residual SYNTAX score. In addition, there was a positive correlation between the systemic immune-inflammatory index and residual SYNTAX score ( r = 0.350, P < .001). In the receiver operating characteristic curve analysis, the systemic immune-inflammatory index with an optimal threshold value of 1025.1 could detect the presence of a high ­residual SYNTAX score with 73.8% sensitivity and 72.3% specificity. Conclusion: Systemic immune-inflammatory index, an inexpensive and easily measurable laboratory variable, was an independent predictor of the increased residual SYNTAX score in patients with ST-segment elevation myocardial infarction.

Exploring the utility of a latent variable as comprehensive inflammatory prognostic index in critically ill patients with cerebral infarction

“…Together, they capture various aspects of the systemic inflammatory response and coagulation process, key factors influencing outcomes in cerebral infarction patients ( 32 ). Inflammation is a key mechanism in stroke, and the post-stroke inflammatory response plays a vital role in secondary brain injury and activation of coagulation ( 33 , 34 ). The disruption of normal coagulation processes after cerebral infarction can lead to exacerbated ischemic damage in the brain, and also activate multiple inflammatory pathways ( 35 ).…”

Favorable factors for the survival of ST-segment elevation myocardial infarction patients with medium- and high-risk thrombolysis in myocardial infarction scores

“…Evidence suggests that monotherapy with an oral P2Y12 inhibitor after short DAPT regimens is related to myocardial infarction, all-cause mortality, and stroke risks in patients receiving complex PCI [ 21 ]. Nevertheless, since the intricate nature of coronary artery anatomy and the specific clinical circumstances of patients, there is a possibility of encountering adverse events following PCI, including inadequate revascularization [ 22 ] and hemorrhagic events [ 23 ]. It is also noteworthy that timely reperfusion therapy plays a crucial role in mitigating myocardial damage and raising survival in STEMI patients, especially for those at higher risk [ 24 ].…”

Relationship between systemic immune inflammation index and development of complete atrioventricular block in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention

“…In a previous study by Altunova et al, SII was associated with a high residual SYNTAX score in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [ 10 ]. Emerging evidence suggests that dynamic fluctuations in biomarkers like SII could be valuable predictors of long-term adverse cardiovascular events in STEMI patients after undergoing PCI [ 11 ].…”