Systemic immune‐inflammation index is associated with disease activity in patients with ankylosing spondylitis

Wu, Junlai; Yan, Lifang; Chai, Kexia

doi:10.1002/jcla.23964

Cited by 79 publications

(74 citation statements)

References 35 publications

(58 reference statements)

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“…In addition, it was correlated with ESR ( P = .003), CRP ( P = .001), and ASDAS ( P = .013). A study by Wu et al 72 is consistent with our findings, except that they used bath ankylosing spondylitis disease activity index (BASDAI) instead of ASDAS as an activity index. Our results support Wu et al 72 results that SII could be a novel biomarker for assessing AS activity.…”

Section: Discussionsupporting

confidence: 92%

Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

Taha

Samaan

Ibrahim

et al. 2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

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Background: In clinical practice, distinguishing disease activity in patients with rheumatological illnesses is challenging. Objectives: We aimed to investigate clinical associations of hemogram-derived indices, namely: red cell distribution width (RDW), mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation index (SII) with disease activity in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and ankylosing spondylitis (AS). Methods: In 250 patients with rheumatological disease and 100 healthy age-matched controls, we investigated disease activity scores and indicators and evaluated their association with hemogram-derived indices values. Results: Compared with the control group, RDW, MPV, and PLR significantly increased ( P < .001) in the three studied disorders (RA, SLE, and AS), but LMR dramatically decreased. SII was considerably higher in RA and AS patients compared with controls but not in SLE patients. On the other hand, NLR rose dramatically in SLE patients compared with controls ( P = .043), but did not change much in RA and AS patients ( P > .05). RDW and MPV showed significant changes ( P < .001) in the three studied diseases (RA, SLE, and AS) according to disease activity. They significantly increased across worsening activity scores. Only in the SLE group, PLR was significantly increased with disease activity ( P < .001), while LMR showed a significant decrease ( P = .016). Conclusions: Clinicians must pay close attention to complete blood count (CBC) analysis and its various derived ratios to better characterize the activity of rheumatological disorders and anticipate the disease course and prognosis.

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Section: Discussionsupporting

confidence: 92%

Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

Taha

Samaan

Ibrahim

et al. 2022

Clin Med�Insights�Arthritis�Musculoskelet Disord

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“…AS is an autoimmune disease with poorly-defined etiology and pathogenesis ( 70 – 72 ). Thus, more effort is needed to elucidate the underlying pathobiology so as to develop novel, mechanism-driven therapeutics.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Emerging Roles of Long Non-Coding RNAs in Ankylosing Spondylitis

et al. 2022

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Ankylosing spondylitis (AS) is a chronic systemic autoimmune disease characterized by inflammation, bone erosion, spur formation of the spine and the sacroiliac joints. However, the etiology and molecular pathogenesis of AS remain largely unclear. Recently, a growing number of studies showed that long non-coding RNAs (lncRNAs) played critical roles in the development and progression of autoimmune and orthopedic conditions, including AS. Studies demonstrated that a myriad of lncRNAs (e.g. H19, MEG3, LOC645166) pertinent to regulation of inflammatory signals were deregulated in AS. A number of lncRNAs might also serve as new biomarkers for the diagnosis and predicting the outcomes of AS. In this review, we summarize lncRNA profiling studies on AS and the functional roles and mechanism of key lncRNAs relevant to AS pathogenesis. We also discuss their potential values as biomarkers and druggable targets for this potentially disabling condition.

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“…Cellular components of blood and their ratios may give insight into the extent of ongoing inflammation. In recent years, there has been a trend in clinical practice to utilize inflammation-based indexes as assessment tools for disease activity of various kinds of inflammatory diseases and prognostic indicators in the survival of patients with malignant tumors (6)(7)(8)(9). Furthermore, SII may be a potentially helpful index in clinical practice to follow-up and manage these patients by monitoring response to anti-inflammatory treatment modalities.…”

Section: Discussionmentioning

confidence: 99%

“…Complete blood cell count parameters (CBC) have recently emerged as valuable biomarkers of many inflammatory diseases because of their availability and affordability. Pretreatment CBC-based biomarkers have been reported to reflect systemic and local inflammation associated with cancer progression and prognosis inflammation and oxidative stress in chronic inflammatory and autoimmune diseases (6)(7)(8)(9). We aimed to investigate the dynamic changes in hemogram parameters before and after colchicine treatment in BD patients and investigate the anti-inflammatory effect of colchicine on these parameters and their value for BD.…”

Section: Introductionmentioning

confidence: 99%

The effect of colchicine treatment on complete blood cell count-based parameters in patients with Behçet's disease

Tezcan

Turan

Yılmaz

2022

Journal of Health Sciences and Medicine

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Aim: Behçet's disease (BD) is a systemic disease, with still unknown etiology and pathogenesis and varying disease presentations, characterized by recurrent oral aphthae, followed by genital ulcers, arthritis, variable skin and ocular lesions, gastrointestinal and central nervous system involvement, as well as, vascular disease. Colchicine is one of the oldest remedies still in use today.The study aimed to investigate the effect of colchicine on levels of the complete blood cell count-based parameters in BD. Material and Method:A total of 117 (participants 60 healthy control and 57 patients with BD) were recruited from the rheumatology department in a single-center case-control study. The laboratory data were obtained from the electronic registration database. Laboratory findings of patients and healthy controls were evaluated. In addition, patients with BD were evaluated for these parameters before colchicine therapy and after 3-month from the beginning of colchicine treatment. Results:The levels of inflammatory markers such as neutrophil count, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and systemic immune-inflammation index (SII), significantly higher than the control group before treatment, decreased to similar levels with the control group in the third month of colchicine use. However, red blood cell distribution width (RDW), mean platelet volume (MPV), and plateletcrit (PCT) were still statistically significantly different from the control group in BD patients.Conclusion: SII, CRP, ESR, and NLR are useful parameters to evaluate the colchicine response of patients with mucocutaneous BD.

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Systemic immune‐inflammation index is associated with disease activity in patients with ankylosing spondylitis

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 79 publications

References 35 publications

Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

Can Complete Blood Count Picture Tell Us More About the Activity of Rheumatological Diseases?

Emerging Roles of Long Non-Coding RNAs in Ankylosing Spondylitis

The effect of colchicine treatment on complete blood cell count-based parameters in patients with Behçet's disease

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