Systemic endotheliitis in terms of novel coronavirus infection COVID-19: gender-related and perinatal risks

Chkhaidze, I. Z.; Lioznov, Dmitry; Петрищев, Н. Н.; Ниаури, Д. А.

doi:10.24884/1682-6655-2021-20-4-4-13

Cited by 7 publications

(1 citation statement)

References 67 publications

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“…Попередні дані свідчать про можливість негативного впливу на стан плода системної запальної реакції, яка розвивається в організмі вагітних у відповідь на SARS-COV-2-інфекцію [37]. Для уточнення цих дуже важливих даних необхідні подальші дослідження [38][39][40]. На сьогодні в доступній літературі недостатньо інформації для підтвердження вертикальної трансмісії вірусу SARS-CoV-2 від вагітної до внутрішньоутробного плода, хоча більшість фахівців не виключають теоретично такої можливості.…”

Section: перспективи майбутніх дослідженьunclassified

Pregnancy and perinatal outcomes of COVID-19 (SARS-CoV-2)

Herevych

Zhabchenko

Kravtsova

et al. 2022

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This article presents current data on the impact of COVID-19 (SARS-CoV-2) on pregnancy and perinatal consequences. The working theories of the pathogenesis of obstetric and fetal complications due to infection during pregnancy, already proven to date, are considered.Symptoms of COVID-19 disease, the risk of their development, and frequency of severe disease in non-pregnant and pregnant women of reproductive age do not differ significantly. However, there are powerful studies that have shown that this infection in pregnant women leads to a high probability of a dramatically severe and fulminant course. Pregnant women with SARS-CoV-2 infection have an increased risk of preeclampsia, incl. severe, hemolysis, thrombocytopenia and increased levels of liver enzymes compared with pregnant women without infection. Women who have COVID-19 are twice as likely to have preterm rupture of the membranes and three times as likely to have a preterm birth compared to the not infected pregnant women.Vertical transmission of the virus from mother to fetus is likely, but data are insufficient to be certain. There is also insufficient evidence of an increased miscarriage rate and teratogenic effects of the COVID-19 virus. However, antenatal fetal death is statistically significantly more common in infected pregnant women than in uninfected pregnant women. Morphological and functional disorders in the chorion/placenta are the main pathogenetic factor in the development of preeclampsia, intrauterine growth retardation, antenatal fetal death and impaired state of the fetus and children born by women with COVID-19.Many studies report that mothers with confirmed COVID-19 infection has asymptomatic babies. At the same time, some studies indicate adverse complications in newborns from infected mothers. The most common neonatal disorders in babies from pregnant women with COVID-19 are tachypnea, hyperthermia, and gastrointestinal disorders, in particular vomiting and flatulence.

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Section: перспективи майбутніх дослідженьunclassified

Pregnancy and perinatal outcomes of COVID-19 (SARS-CoV-2)

Herevych

Zhabchenko

Kravtsova

et al. 2022

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Novel coronavirus infection and pregnancy: features of the course of gestation and the possibility of predicting the progression of COVID-19 severity in pregnant women

Tezikov¹,

Липатов²,

Yakusheva³

2023

Ross. vestn. akush.-ginekol.

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Microcirculatory disorders in the forearm skin in the acute phase of COVID-19 according to laser Doppler flowmetry

Fedorovich

Markov²,

Malishevsky³

et al. 2022

Regional blood circulation and microcirculation

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Aim – to study the functional state of the microvessels of the forearm skin in the acute phase of COVID-19 using the LDF method. Materials and methods. The study included 53 patients of moderate COVID-19. During the first day of hospitalization, all patients underwent LDF with amplitude-frequency Fourier analysis of tissue perfusion fluctuations using a portable LDF device with remote data transmission via Bluetooth protocol. The comparison group (CG) consisted of 28 healthy subjects matched in age and gender. Results. Patients in the acute phase of COVID-19, relative to CG, are noticed a decrease in the amplitude of endothelial vasomotions (Ae) – 0.0149 and 0.0198 PU (p<0.00005), an increase in the amplitude of myogenic vasomotions (Am) – 0.078 and 0.061 PU (p<0.01), an increase in the amplitude of blood flow pulse oscillations – 1.38 and 1.18 PU (p<0.01) and an increase in respiratory related blood flow oscillations – 0.48 and 0.29 PU (p<0.000001) respectively. Conclusion. The systemic inflammatory process in the acute phase of COVID-19 at the level of the skin microvasculature is characterized by: 1) vasomotor dysfunction of the endothelium; 2) a decrease of the perfusion efficiency of the endothelial regulation mechanism; 3) a decrease of the basal tone of smooth muscle cells of precapillary arterioles and capillary sphincters; 4) an increase of arterial blood flow to the capillary bed; 5) violation of the blood outflow from the microvasculature with the development of venular plethora.

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Systemic endotheliitis in terms of novel coronavirus infection COVID-19: gender-related and perinatal risks

Cited by 7 publications

References 67 publications

Pregnancy and perinatal outcomes of COVID-19 (SARS-CoV-2)

Pregnancy and perinatal outcomes of COVID-19 (SARS-CoV-2)

Novel coronavirus infection and pregnancy: features of the course of gestation and the possibility of predicting the progression of COVID-19 severity in pregnant women

Microcirculatory disorders in the forearm skin in the acute phase of COVID-19 according to laser Doppler flowmetry

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