Systemic effects of epidural and intra-articular glucocorticoid injections in diabetic and non-diabetic patients

Younès, M.; Neffati, Fadoua; Touzi, M.; Hassen-Zrour, Saoussen; Fendri, Y.; Béjia, I.; Amor, A. Ben; Bergaoui, N.; Najjar, Mohamed Fadhel

doi:10.1016/j.jbspin.2006.10.009

Cited by 100 publications

(72 citation statements)

References 20 publications

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“…There are studies that suggest a possible systemic effect of steroids used in ESI. In these studies investigating the systemic effects of epidural and intraarticular glucocorticoid injections, a significant increase was reported in the glucose levels of diabetic and nondiabetic patients (27)(28)(29). In our study, a clinically insignificant increase in WBC values was found after both groups received ESI.…”

Section: Discussionsupporting

confidence: 46%

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Pirbudak¹,

Çiçek²,

Işık³

et al. 2015

Turk J Med Sci

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Background/aim: To compare the effects of tramadol-only treatment and tramadol + gabapentin treatment in patients who had received an epidural steroid injection. Materials and methods:Forty patients with hernia disc-originated acute lumbar discogenic pain were evaluated. All patients received a single dose of steroid and local anesthesia mixture epidurally via the lumbar approach. In both groups, Group T (tramadol, n = 20) and Group TG (tramadol + gabapentin, n = 20), the injection dose was adjusted to 4 mL of triamcinolone acetonide and 0.25% bupivacaine mixture. Orally, 75 mg/day tramadol or 75 mg/day tramadol + 900 mg/day gabapentin were added to the treatment. Leukocyte, erythrocyte sedimentation rate, C-reactive protein, and urine serotonin levels were measured prior to and after treatment. The effectiveness of the treatment was evaluated by visual analog scale (VAS), Oswestry Disability Index (ODI), and straight leg elevation test (SLET).Results: Similar improvements in VAS, ODI, and SLET values were observed in both groups in the second week. The inflammation markers were not different after treatment, neither within the groups nor between the groups. Conclusion:This study revealed that tramadol + gabapentin treatment was not superior to tramadol treatment.

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Section: Discussionsupporting

confidence: 46%

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Pirbudak¹,

Çiçek²,

Işık³

et al. 2015

Turk J Med Sci

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show abstract

“…The pathogenesis of SEL associated with epidural steroid injection is unknown. Epidural steroid injection has potential systemic effects that suppress the hypothalamicpituitary-adrenal axis, induce hypertension, elevate glucose level, and affect bone growth [18,19]. Injected The authors did not check radiologic image before epidural steroid injection steroids in the epidural space penetrate into the blood stream and may promote fat deposition in the epidural space.…”

Section: Discussionmentioning

confidence: 99%

Rapid progression of spinal epidural lipomatosis

et al. 2011

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Spinal epidural lipomatosis (SEL) is a rare but well-recognized condition. In general, the onset of its symptoms is insidious and the disease progresses slowly. We report two cases of rapid progression of SEL with no history of steroid intake in non-obese individuals after epidural steroid injection. These SEL patients developed neurologic symptoms after less than 5 months; these symptoms were confirmed to be due to SEL by serial MR images. After the debulking of the epidural fat, their symptoms improved.

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“…Поэтому не следует проводить инъекции ГК более 2-3 раз в год в один анато-мический объект [34]. Кроме того, системное действие ГК может приводить к повышению АД и уровня глюкозы (что важно для страдающих сахарным диабетом), а также дру-гим НР [38][39][40][41].…”

Section: глюкокортикоидыunclassified

Pain and Inflammation. Part 2. The Analgesic Potential of Anti-Inflammatory Drugs

Каратеев¹,

Каратеев²,

Davydov³

2017

rsp

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Systemic effects of epidural and intra-articular glucocorticoid injections in diabetic and non-diabetic patients

Cited by 100 publications

References 20 publications

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

The effect of tramadol and tramadol + gabapentin combination in patients with lumbar disc herniation after epidural steroid injection

Rapid progression of spinal epidural lipomatosis

Pain and Inflammation. Part 2. The Analgesic Potential of Anti-Inflammatory Drugs

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