Systemic Capillary Leak Syndrome

Teelucksingh, Surujpal; Padfield, P L

doi:10.1016/s0140-6736(89)91343-3

Cited by 41 publications

(55 citation statements)

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“…Capillary leak syndrome is characterized by the symtoms caused by the capillary hyperpermeability resulting in a shift of fluid and protein from the intravascular to extravascular space (9). Since our patients were critically ill when the symptoms appeared, we could not perform thoracocentesis or transbronchial lung biopsy to prove the pathological nature of the disease.…”

Section: Discussionmentioning

confidence: 99%

Capillary Leak Syndrome Likely the Result of Granulocyte Colony-Stimulating Factor after High-Dose Chemotherapy.

et al. 1994

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Twocases of malignant lymphomacomplicated with capillary leak syndrome following super high-dose chemotherapy and administration ofgranulocyte colony-stimulating factor (G-CSF) are presented. Subsequent to the nadir of granulocytes, and at the stage of rapid increase of granulocytes, the symptoms of fever, hypotension, dyspnea, pleural eflusion and edema appeared, and laboratory data revealed hypoxia, hypocapnia and hypoalbuminemia. In addition, an abscesslike lesion was observed in the liver in one patient. After the administration of G-CSFwas ceased or decreased, and pulse therapy with methylprednisolone was initiated, these symptoms disappeared quickly.

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Section: Discussionmentioning

confidence: 99%

Capillary Leak Syndrome Likely the Result of Granulocyte Colony-Stimulating Factor after High-Dose Chemotherapy.

et al. 1994

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“…15,16 In 1992 and 1999, 2 small case series from our institution reported on the efficacy of terbutaline and aminophylline in treating this disorder. 17,18 In 1997, a larger, multicenter, retrospective study by Amoura et al 19 outlined the course of SCLS and evaluated the efficacy of the available therapy in a cohort of 13 patients.…”

confidence: 99%

Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience

Jkapoor¹,

Greipp²,

Schaefer³

et al. 2010

SciVee

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Objective: To determine clinical features, natural history, and outcome of a well-defined cohort of 25 consecutive patients with idiopathic systemic capillary leak syndrome (SCLS) evaluated at a tertiary care center. Results: Of the 34 patients whose records were reviewed, 25 fulfilled all diagnostic criteria for SCLS. The median age at diagnosis of SCLS was 44 years. Median follow-up of surviving patients was 4.9 years, and median time to diagnosis from symptom onset was 1.1 years (interquartile range, 0.5-4.1 years). Flulike illness or myalgia was reported by 14 patients (56%) at onset of an acute attack of SCLS, and rhabdomyolysis developed in 9 patients (36%). Patients with a greater decrease in albumin level had a higher likelihood of developing rhabdomyolysis (p=.03). Monoclonal gammopathy, predominantly of the IgG-κ type, was found in 19 patients (76%). The progression rate to multiple myeloma was 0.7% per person-year of follow-up. The overall response rate to the different therapies was 76%, and 24% of patients sustained durable (>2 years) complete remission. The estimated 5-year overall survival rate was 76% (95% confidence interval, 59%-97%).cOnclusiOn: Systemic capillary leak syndrome, a rare disease that occurs in those of middle age, is usually diagnosed after a considerable delay from onset of symptoms. The degree of albumin decrement during an attack correlates with development of rhabdomyolysis. A reduction in the frequency and/or the severity of attacks was seen in nearly three-fourths of patients who were offered empirical therapies. The rate of progression to multiple myeloma appears to be comparable to that of monoclonal gammopathy of undetermined significance. Clin proc. 2010;85(10):905-912 Mayo

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“…These include reports of increased LTE4 (leukotriene E4) urinary excretion (5), increased IL-2 receptor positive cells (6) and increased CD8 cells surrounding endothelial cells (7). Complement levels are usually normal (3). The role of the monoclonal protein found in the sera of many of the cases remains uncertain, with one report demonstrating in vitro endothelial cell apoptosis on exposure to purified monoclonal protein (9), whereas another found no effect (8) T a b l e 1 .…”

Section: A 24-year-old Man Was Admitted To Our Hospital With Circulatmentioning

confidence: 99%

Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

Dhir¹,

Arya²,

Malav³

et al. 2007

Intern. Med.

109

115

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Systemic Capillary Leak Syndrome

Cited by 41 publications

References 0 publications

Capillary Leak Syndrome Likely the Result of Granulocyte Colony-Stimulating Factor after High-Dose Chemotherapy.

Capillary Leak Syndrome Likely the Result of Granulocyte Colony-Stimulating Factor after High-Dose Chemotherapy.

Idiopathic Systemic Capillary Leak Syndrome (Clarkson's Disease): The Mayo Clinic Experience

Idiopathic Systemic Capillary Leak Syndrome(SCLS): Case Report and Systematic Review of Cases Reported in the Last 16 years

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