Systemic antibiotics for treating diabetic foot infections

Antibiotic therapy of diabetic foot infections: A systematic review of randomized controlled trials

“…We only included studies whose participants were all diabetic, not due to trauma, burns, bites or any other possible cause of foot wound infection. This is responsible for the discrepancy in included studies found between our review and the former two reviews …”

Antibiotic therapy of diabetic foot infections: A systematic review of randomized controlled trials

“…We only included studies whose participants were all diabetic, not due to trauma, burns, bites or any other possible cause of foot wound infection. This is responsible for the discrepancy in included studies found between our review and the former two reviews …”

Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections

“…Thirdly, we live in a resource-rich, small city with a low endemicity of multi-resistant pathogens. Our findings could be different in other settings with difficulties accessing costly intravenous medication [30,31] or high endemicity of community-acquired, (gram-negative) multi-resistant pathogens [21,23,32,33]. Fourthly, we ignore the exact reason for a preoperative antibiotic prescription.…”

“…Our database was too heterogenous to dissect if any particular antimicrobial agent, in monotherapy or as a combined treatment, would change the general findings. Statistically speaking, we cannot control for the large case mix with its different infection strata [18], patients’ co-morbidities [19], infection localizations [20], causative pathogens [21,22], antimicrobial agents and doses [23], surgical techniques [24], drug interactions with myriads of co-medications [25], and important ischemia parameters [19]. Nonetheless, at a glance at the composite database, we failed to detect any specific presurgical antibiotic patterns, as per the observational lecture, which would have demonstrated a striking difference.…”

Systemic Antimicrobial Therapy for Diabetic Foot Infections: An Overview of Systematic Reviews

“…Peters et al [14] interpret the interventions as broadly equivalent, except for TGC versus ETP. The overall conclusions for all the interventions reported in the Cochrane review and the NICE review are similar [11,13]. When comparing fluoroquinolones with TZP/AMC, Peters et al [14] graded Schaper et al [19] as high quality, whereas the NICE review graded it as moderate quality [13].…”

“…Five systematic reviews included RCTs only, and one included RCTs and observational studies. Of the 29 individual studies included in the systematic reviews, 4 were published within the last 10 years, and the year published ranged from 1983 to 2016 [ 11 , 13 , 14 , 15 , 16 , 17 ]. The 2015 Cochrane review included RCTs investigating systemic antimicrobials for DFI [ 11 ].…”

Antibiotic therapy of diabetic foot infections: A systematic review of randomized controlled trials

“…We only included studies whose participants were all diabetic, not due to trauma, burns, bites or any other possible cause of foot wound infection. This is responsible for the discrepancy in included studies found between our review and the former two reviews …”

Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections

“…Thirdly, we live in a resource-rich, small city with a low endemicity of multi-resistant pathogens. Our findings could be different in other settings with difficulties accessing costly intravenous medication [30,31] or high endemicity of community-acquired, (gram-negative) multi-resistant pathogens [21,23,32,33]. Fourthly, we ignore the exact reason for a preoperative antibiotic prescription.…”

“…Our database was too heterogenous to dissect if any particular antimicrobial agent, in monotherapy or as a combined treatment, would change the general findings. Statistically speaking, we cannot control for the large case mix with its different infection strata [18], patients’ co-morbidities [19], infection localizations [20], causative pathogens [21,22], antimicrobial agents and doses [23], surgical techniques [24], drug interactions with myriads of co-medications [25], and important ischemia parameters [19]. Nonetheless, at a glance at the composite database, we failed to detect any specific presurgical antibiotic patterns, as per the observational lecture, which would have demonstrated a striking difference.…”

Systemic Antimicrobial Therapy for Diabetic Foot Infections: An Overview of Systematic Reviews

“…Peters et al [14] interpret the interventions as broadly equivalent, except for TGC versus ETP. The overall conclusions for all the interventions reported in the Cochrane review and the NICE review are similar [11,13]. When comparing fluoroquinolones with TZP/AMC, Peters et al [14] graded Schaper et al [19] as high quality, whereas the NICE review graded it as moderate quality [13].…”

“…Five systematic reviews included RCTs only, and one included RCTs and observational studies. Of the 29 individual studies included in the systematic reviews, 4 were published within the last 10 years, and the year published ranged from 1983 to 2016 [ 11 , 13 , 14 , 15 , 16 , 17 ]. The 2015 Cochrane review included RCTs investigating systemic antimicrobials for DFI [ 11 ].…”

Antibiotic therapy of diabetic foot infections: A systematic review of randomized controlled trials

“…We only included studies whose participants were all diabetic, not due to trauma, burns, bites or any other possible cause of foot wound infection. This is responsible for the discrepancy in included studies found between our review and the former two reviews …”

Preoperative Antibiotic Administration Does Not Improve the Outcomes of Operated Diabetic Foot Infections

“…Thirdly, we live in a resource-rich, small city with a low endemicity of multi-resistant pathogens. Our findings could be different in other settings with difficulties accessing costly intravenous medication [30,31] or high endemicity of community-acquired, (gram-negative) multi-resistant pathogens [21,23,32,33]. Fourthly, we ignore the exact reason for a preoperative antibiotic prescription.…”

“…Our database was too heterogenous to dissect if any particular antimicrobial agent, in monotherapy or as a combined treatment, would change the general findings. Statistically speaking, we cannot control for the large case mix with its different infection strata [18], patients’ co-morbidities [19], infection localizations [20], causative pathogens [21,22], antimicrobial agents and doses [23], surgical techniques [24], drug interactions with myriads of co-medications [25], and important ischemia parameters [19]. Nonetheless, at a glance at the composite database, we failed to detect any specific presurgical antibiotic patterns, as per the observational lecture, which would have demonstrated a striking difference.…”

Systemic Antimicrobial Therapy for Diabetic Foot Infections: An Overview of Systematic Reviews

“…Peters et al [14] interpret the interventions as broadly equivalent, except for TGC versus ETP. The overall conclusions for all the interventions reported in the Cochrane review and the NICE review are similar [11,13]. When comparing fluoroquinolones with TZP/AMC, Peters et al [14] graded Schaper et al [19] as high quality, whereas the NICE review graded it as moderate quality [13].…”

“…Five systematic reviews included RCTs only, and one included RCTs and observational studies. Of the 29 individual studies included in the systematic reviews, 4 were published within the last 10 years, and the year published ranged from 1983 to 2016 [ 11 , 13 , 14 , 15 , 16 , 17 ]. The 2015 Cochrane review included RCTs investigating systemic antimicrobials for DFI [ 11 ].…”