Systemic Analysis on Risk Factors for Breast Cancer Related Lymphedema

Zhu, Yaqun; Xie, Yuhuan; Liu, Feng-Huan; Guo, Qi; Shen, Ping; Tian, Ye

doi:10.7314/apjcp.2014.15.16.6535

Cited by 44 publications

(43 citation statements)

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“…Breast cancer is the most prevalent malignancy in women around the world (Chauhan et al, 2011;Kanaga et al, 2011;Akhtari-Zavare et al, 2014;Erbil and Bolukbas, 2014;Bouguerra et al, 2014;Fallahzadeh et al, 2014;Karadag et al, 2014;Sathian et al, 2014;Sreedevi et al, 2014;Zhu et al, 2014). Breast cancer comprises 23% of all cancer cases diagnosed across the globe (Jemal et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The Spectrum of Genetic Mutations in Breast Cancer

Sheikh

Hussain

Ghori

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Breast cancer is the most common malignancy in women around the world. About one in 12 women in the West develop breast cancer at some point in life. It is estimated that 5%-10% of all breast cancer cases in women are linked to hereditary susceptibility due to mutations in autosomal dominant genes. The two key players associated with high breast cancer risk are mutations in BRCA 1 and BRCA 2. Another highly important mutation can occur in TP53 resulting in a triple negative breast cancer. However, the great majority of breast cancer cases are not related to a mutated gene of high penetrance, but to genes of low penetrance such as CHEK2, CDH1, NBS1, RAD50, BRIP1 and PALB2, which are frequently mutated in the general population. In this review, we discuss the entire spectrum of mutations which are associated with breast cancer.

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Section: Introductionmentioning

confidence: 99%

The Spectrum of Genetic Mutations in Breast Cancer

Sheikh

Hussain

Ghori

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Bizim çalışmamızda hastaların tamamına yakını post-operatif dönemde kemoterapi almıştı. Kemoterapi alan hastalar hastalığın daha ileri evrelerinde olduklarından daha invazif cerrahi geçirme ve post-operatif dönemde radyoterapi görme eğiliminde olmaktadırlar 7 . Kemoterapinin MKİL ile ilişkisi direkt olarak açıklanamasa da bu şekilde indirekt olarak ilişkili olabileceği ileri sürülmüştür.…”

Section: Gereç Ve Yöntemunclassified

“…Literatürde, lenfödem görülme sıklığının %6-%70 gibi geniş bir aralıkta olduğu belirtilmektedir 5,6 . Aksiller lenf nodu diseksiyonu, kemoterapi, radyoterapi, operasyon sonrası operasyon bölgesinde enfeksiyon gelişmesi ve obezite MKİL için tanımlanmış risk faktörleridir 7 .…”

Section: Introductionunclassified

Effects of breast cancer related lymphedema on hand muscle strength, hand functions and sensory loss of hand

Civelek¹

2016

Cukurova Med J

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AbstractÖz Purpose: In this study, we aimed to investigate clinical features of patients with breast cancer related lymphedema (BCRL) and effects of BCRL on hand muscle strength and function. Materials and Methods: Patients applying to oncologic rehabilitation polyclinic with right hand dominancy were included in the study. Clinical and demographic data of all patients were noted, physical examinations were performed. The presence of shoulder pain was questioned. To determine the hand grip strength Jamar hand dynamometer and to evaluate the tip pinch strength pinchmeter were used. Sensory loss was assessed with Semmes-Weinstein monofilament test, hand volume measurement was made with hand volumeter. Results: Thirty two female patients with mean age 54.5 ± 11.4 (mean ± SD) were included in the study. Axillary dissection was performed in all patients. 62.5% of patients received radiotherapy in post-operative period, 96.9% received chemotherapy. 78.1% of patients reported that they had shoulder pain on the affected side. In the right side affected group and the left side affected group, there were no significant differences in grip strengths, hand functions, sensory loss and volumes between right and left hands. The tip pinch strength of the right hand was higher than the left side in the left side affected group. Conclusion: In patients with BCRL, having axillary dissection, receiving chemotherapy and radiotherapy in post-operative period, obesity and shoulder pain are common. Evaluation of patients with BCRL should be made in details, should be versatile and should include questioning shoulder pain and hand evaluation.Amaç: Bu çalışmada meme kanseri ile ilişkili lenfödem'i (MKİL) olan hastaların klinik özelliklerini tanımlamak, MKİL'in el kas gücü ve fonksiyonlarına etkisini araştırmak amaçlanmıştır. Gereç ve Yöntem: Çalışmaya onkolojik rehabilitasyon polikliniğine başvuran MKİL'i olan sağ eli dominant kadınlar dahil edildi. Çalışma prospektif olarak yürütüldü. Tüm hastaların klinik ve demografik bilgileri not edildi, fizik muayeneleri yapıldı. Omuz ağrısı varlığı sorgulandı. Elin kavrama gücünü belirlemek amacıyla Jamar el dinamometresi, parmak ucu kavramalarını değerlendirmek icin pinçmetre kullanıldı. Semmes-Weinstein monofilaman testi ile duyusal kayıplar, el volümetresi ile el volümleri değerlendirildi. Bulgular: Çalışmaya yaş ortalaması 54.5±11.4 (ortalama±SS) olan 32 kadın hasta dahil edildi. Hastaların tamamına aksiller diseksiyon yapılmıştı. Hastaların %62,5'i post-operatif dönemde radyoterapi, %96,9'u kemoterapi almıştı. Hastaların %78,1'i etkilenen tarafta omuz ağrısı olduğunu bildirdi. Sağ tarafı etkilenmiş grupta ve sol tarafı etkilenmiş grupta, sağ el ve sol elin kaba kavrama güçleri, el becerileri, duyu kaybı ve volümleri arasında anlamlı fark saptanmadı. Sol tarafı etkilenmiş grupta sağ elin parmak ucu kavrama gücü ise soldan daha fazlaydı. Sonuç: MKİL'i olan hastalarda aksiler diseksiyon yapılmış olması, post-operatif dönemde kemoterapi ve radyoterapi almış olmak, obezite ve omuz ağrısı sıktır. M...

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“…As employment status (upper extremity use) is one of the risk factors in a multi-factorial etiology of BCRL (Zhu et al, 2014).Therefore, classification of occupations with different upper extremity activity duration is expected to distinguish high-risk patients for BCRL.…”

Section: Introductionmentioning

confidence: 99%

The Interventional Effect of Combined Reducing Occupational Upper Extremity Use and Pneumatic Pump on Breast Cancer Related Lymphedema

Kahla

Ewies³

2016

Egypt. J. Occup. Med.

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Introduction: Breast cancer related lymphedema (BCRL) treatment continues to be a distressing and frequent problem. Aim of Work: To detect the relation between the level of hand use in different occupation and both the grade and stage of BCRL and to determine whether the combined effect of decreased occupational work load of the upper extremities and the use of pneumatic compression pumps could manage BCRL effectively. Materials and Methods: 68 patients with BCRL were selected. Age, body mass index (BMI), history of infection, lymphedema grade and stage, sequential circumferential arm measurements, Visual Analog Scale (VAS), handgrip strength were assessed. All patients underwent pneumatic compression pumping for 3 months combined with changing in their level of hand use. Results: Before intervention, the grades and stages of lymphedema showed statistically significant differences among the different occupational groups (p< 0.05). After applying our interventional measures, statistical significant decrease was detected regarding the VAS and significant increase in right hand grip was observed among one group while the difference of sequential circumferential measurements showed decrease in their values but not to the significant level. Conclusion: Occupations requiring more upper extremity activity had the worst lymphedema clinical grade and stage status. More researches are needed to support our findings and to assess the combined effect of decreased occupational work load of the upper extremities and the use of pneumatic compression pumps.

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Systemic Analysis on Risk Factors for Breast Cancer Related Lymphedema

Cited by 44 publications

References 50 publications

The Spectrum of Genetic Mutations in Breast Cancer

The Spectrum of Genetic Mutations in Breast Cancer

Effects of breast cancer related lymphedema on hand muscle strength, hand functions and sensory loss of hand

The Interventional Effect of Combined Reducing Occupational Upper Extremity Use and Pneumatic Pump on Breast Cancer Related Lymphedema

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