1986
DOI: 10.1001/archderm.122.9.1007
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Systemic absorption of topical steroids. Metabolic effects as an index of mild hypercortisolism

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Cited by 10 publications
(11 citation statements)
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“…Albeit systemic steroids are not the standard treatment in the United States due to the potential for disease worsening, 21 it has to be noted that topical steroids as well, when used on large body surfaces, may be systemically absorbed. 22 This could explain partly the observed increase in risk for diabetes in our study group although adherence with long-term topical steroids use is generally low. 23 Several case reports have suggested a connection between IBD and autoimmune thyroid disease.…”
Section: Discussionmentioning
confidence: 77%
“…Albeit systemic steroids are not the standard treatment in the United States due to the potential for disease worsening, 21 it has to be noted that topical steroids as well, when used on large body surfaces, may be systemically absorbed. 22 This could explain partly the observed increase in risk for diabetes in our study group although adherence with long-term topical steroids use is generally low. 23 Several case reports have suggested a connection between IBD and autoimmune thyroid disease.…”
Section: Discussionmentioning
confidence: 77%
“…Moreover, patients with psoriasis without overt diabetes mellitus often exhibit evidence of insulin resistance 18 . The use of potent topical steroids, long‐term treatment periods, 19 unhealthy lifestyle factors, including hypercaloric intake dietary habits, smoking or alcohol consumption, increased C‐reactive protein levels, 20 or a higher prevalence of HT in psoriatic patients could also lead to an insulin‐resistant status and finally, to developing DM2 12 . Others have suggested a common genetic background in psoriasis and diabetes mellitus 21 …”
Section: Resultsmentioning
confidence: 99%
“…Several studies in humans and animals have shown that dermal or ototopical GCs suppress the HPA axis activity and result in strong adrenal suppression (Garden & Freinkel, 1986; Zenoble & Kemppainen, 1987; Turpeinen, 1988; Patel et al. , 1995; Clark & Lipworth, 1997; Buske‐Kirschbaum et al.…”
Section: Introductionmentioning
confidence: 99%