Systematic spectroscopic investigation of structural changes and corona formation of bovine serum albumin over magneto-fluorescent nanoparticles

Tiwari, Ashish; Bhatia, Prachi; Randhawa, Jaspreet Kaur

doi:10.1039/d0dt02414g

Cited by 9 publications

(5 citation statements)

References 50 publications

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“…33 These materials showed superior MR imaging, bioimaging, uorescence sensing, hyperthermia and targeted drug delivery. [34][35][36][37] Extending the possibility of core-shell SPIONs in opto-electronic applications, we attempted to incorporate nitrogen in core-shell SPIONs using our established protocol. We used a nitrogen-based precursor and the synthesized nitrogen doped carbon coated core-shell SPIONs by optimizing the precursor concentration as detailed in Table S1 in the ESI.…”

Section: One Step Synthesis Method Magnetic Separation and Nanopartic...mentioning

confidence: 99%

Multifunctional fluorescent SPIONs display exceptional optical/magnetic contrast and enhanced photoconductivity in interdigitated electrode based photoresponsive devices

Tiwari,

Debnath,

Moinuddin

et al. 2024

J. Mater. Chem. A

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Section: One Step Synthesis Method Magnetic Separation and Nanopartic...mentioning

confidence: 99%

Multifunctional fluorescent SPIONs display exceptional optical/magnetic contrast and enhanced photoconductivity in interdigitated electrode based photoresponsive devices

Tiwari,

Debnath,

Moinuddin

et al. 2024

J. Mater. Chem. A

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“…Fortunately, significant progress is being made in characterizing the nanoparticle corona as a function of nanomaterials physicochemical properties and the environment in which they are found. A number of studies in the past year have reported a range of spectroscopic, mass spectrometric, and chromatographic methods for characterizing nanoparticle coronas, some of which can be used to study the dynamic properties of biocoronas (figure 4) [78][79][80][81][82][83][84][85][86][87]. These data have enabled development of explanatory and potentially predictive models of nanoparticle corona composition [88][89][90][91][92][93] and dynamic behaviour that form the basis for rational design and development of nanomaterials that attract little or no corona [94].…”

Section: Descriptionmentioning

confidence: 99%

Overcoming roadblocks in computational roadmaps to the future for safe nanotechnology

Karakus¹,

Winkler²

2021

Nano Futures

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The rapid rise of nanotechnology has resulted in a parallel rise in the number of products containing nanomaterials. The unusual properties that nano forms of materials exhibit relative to the bulk has driven intense research interest and relatively rapid adoption by industry. Regulatory agencies are charged with protecting workers, the public, and the environment from any adverse effects of nanomaterials that may also arise because of these novel physical and chemical properties. They need data and models that allow them to flag nanomaterials that may be of concern, while balancing potential stifling of commercial innovation. Roadmaps for the future of safe nanotechnology were defined more than a decade ago, but many roadblocks identified in these studies remain. Here, we discuss the roadblocks that are still hindering the effective application of informatics and predictive computational nanotoxicology methods from providing more effective guidance to nanomaterials regulatory agencies and safe-by-design rationale for industry. We describe how developments in high throughput synthesis, characterization, and biological assessment of nanomaterials will overcome many of these roadblocks, allowing a clearly defined roadmap for computational design of effective but safe-by-design nanomaterials to be realized.

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“…When nanoparticles with high specific surface and high surface charge are in biological fluids, they can interact with proteins to form a protein shell with various conformations named protein corona, which can affect their physicochemical properties and the ability to enter cells [19][20][21][29][30][31]. Thus the interaction of the selected red fractions of CDs 18.5bar , CDs 13bar and CDs 8bar with DMEM serum protein was established exploring the aggregation of them after incubation at 37 • C by DLS measurements.…”

Section: Evaluation Of Serum Protein Interactions By Dynamic Light Sc...mentioning

confidence: 99%

Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications

et al. 2020

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Carbon nanodots (CDs) have recently attracted attention in the field of nanomedicine because of the biocompatibility, cost-effective nature, high specific surface, good near infrared (NIR) photothermal conversion into heat and tunable fluorescence properties, which have paved the way toward incorporating use of CDs into innovative anticancer theranostic platforms. However, a reliable synthesis of CDs with established and controlled physiochemical proprieties is precluded owing to the lack of full manipulation of thermodynamic parameters during the synthesis, thus limiting their use in real world medical applications. Herein, we developed a robust solvothermal protocol which allow fine controlling of temperature and pressure in order to obtain CDs with tunable properties. We obtained different CDs by modulating the operating pressure (from 8 to 18.5 bar) during the solvothermal decomposition of urea and citric acid in N,N-dimethylformamide at fixed composition. Atomic force microscopy (AFM), Fourier transform infrared (FTIR), ultraviolet-visible (UV-vis) and fluorescence spectroscopy were used to assess the role of pressure in influencing size, optical and surface properties of the obtained CDs. While preliminary biological and anticancer performance of CDs was established on the MDA-MB-231 cell line, used as triple negative breast cancer model. Our results indicate that pressure impinge on the formation of carbon nanoparticles under solvothermal conditions and impart desired optical, size distribution, surface functionalization and anticancer properties in a facile way. However, we have highlighted that a strategic surface engineering of these CDs is needed to limit the adsorption of corona proteins and also to increase the average surface diameter, avoiding a rapid renal clearance and improving their therapeutic efficacy in vivo.

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Systematic spectroscopic investigation of structural changes and corona formation of bovine serum albumin over magneto-fluorescent nanoparticles

Abstract: Magneto-fluorescent nanoparticles have spellbound great attention because of their dual nature as an multimodal imaging probe in various biomedical applications. Particulary, it is desirable to understand how these nanoparticles interact...

Cited by 9 publications

References 50 publications

Multifunctional fluorescent SPIONs display exceptional optical/magnetic contrast and enhanced photoconductivity in interdigitated electrode based photoresponsive devices

Multifunctional fluorescent SPIONs display exceptional optical/magnetic contrast and enhanced photoconductivity in interdigitated electrode based photoresponsive devices

Overcoming roadblocks in computational roadmaps to the future for safe nanotechnology

Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications

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