Systematic Review of Functional Outcomes in Cancer Rehabilitation

Sleight, Alix G.; Gerber, Lynn H.; Marshall, Timothy; Livinski, Alicia A.; Alfano, Catherine M.; Harrington, Shana; Flores, Ann Marie; Virani, Aneesha; Hu, Xiaorong; Mitchell, Sandra A.; Varedi, Mitra; Eden, Melissa M.; Hayek, Samah; Reigle, Beverly S.; Kerkman, Anya; Neves, Raquel; Jablonoski, Kathleen; Hacker, Eileen Danaher; Sun, Virginia; Newman, Robin; McDonnell, Karen Kane; L’Hotta, Allison J.; Schoenhals, Alana; Stout, Nicole L.

doi:10.1016/j.apmr.2022.01.142

Cited by 44 publications

(35 citation statements)

References 359 publications

(381 reference statements)

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“…In this scenario, rehabilitation plays a key role in the management of BC survivors with growing evidence highlighting its positive effects in improving functional outcomes and psychosocial well-being of BC patients ( Reid-Arndt et al, 2009 ; Zaidi et al, 2017 ; Kudre et al, 2020 ; Sleight et al, 2022 ). Hence, rehabilitation might improve the symptoms of patients with breast cancer–related lymphedema ( Invernizzi et al, 2019 ; Michelotti et al, 2019 ; de Sire et al, 2021a ; Carretti et al, 2022 ; Muñoz-Alcaraz et al, 2022 ; Omar et al, 2022 ), cancer-related fatigue ( Wirtz and Baumann, 2018 ; Adams et al, 2019 ; Invernizzi et al, 2020b ; Marechal et al, 2020 ; Licht et al, 2021 ), axillary web syndrome ( de Sire et al, 2020 ; Ravichandran et al, 2020 ; Tay et al, 2021 ), aromatase inhibitor–induced arthralgia ( Harris et al, 2012 ; Winters-Stone et al, 2012 ; Grizzi et al, 2020 ), and cancer treatment–induced bone loss ( Invernizzi et al, 2020a ; de Sire et al, 2021b ; Pagnotti et al, 2021 ; Singh and Toohey, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Invernizzi

Lippi

Folli

et al. 2022

Front. Mol. Biosci.

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Background: Quality of life issues is a crucial burden in breast cancer (BC) survivors with relevant implications in terms of survivorship and health-care costs. The increasing long-term survival of these patients provides new challenges, with translational research now focusing on innovative and tailored approaches to improve their complex management. In this scenario, several emerging biomarkers have the potential to improve the clinical rehabilitative management of patients with BC. However, to date, guidelines supporting biomarker implementation in this area are still lacking. Therefore, the aim of this systematic review was to summarize the currently available biomarkers that might be potentially integrated into rehabilitation practice to promote a precision medicine approach to BC survivorship issues.Methods: On 9th March 2022, PubMed, Scopus, Web of Science, Cochrane, and PEDro were systematically searched for randomized controlled trials (RCTs) assessing rehabilitation interventions in BC patients. Molecular biomarker modifications induced by physical exercise have been assessed through the review of the study protocols and published results. The Jadad scale was used to assess the quality of the studies included.Results: Out of 2,224 records, 22 studies were included in the present systematic review. Exercise therapy showed significant results in 15 RCTs, in terms of metabolic biomarkers, including glycemic and insulin profile, and lipid profile (p ≤ 0.05). Similarly, 12 studies underlined significant effects in inflammation and immune response biomarkers, including TNF-α, IL-6, IL-10, C-reactive protein, leptin, and adiponectin (p ≤ 0.05). On the other hand, cardiac biomarkers were assessed in three studies without reporting significant differences after exercise therapy (p = NS). The quality assessment identified 19 RCTs as high-quality studies and three RCTs of low quality.Conclusion: Our findings reveal significant biochemical perturbations in key molecules induced by physical exercise in patients with BC, suggesting room for the implementation of actionable biomarkers. Future research might clarify the role of biomarkers on treatment effectiveness monitoring, to optimize rehabilitative strategies tailored to patient’s needs.

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Section: Introductionmentioning

confidence: 99%

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Invernizzi

Lippi

Folli

et al. 2022

Front. Mol. Biosci.

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“…Specifically, endoscopic dilation can lead to improvement in dysphagia in select patients at risk of pharyngo‐esophageal junction stricture 24 . Tailored rehabilitation exercises targeting shoulder dysfunction can improve function and HRQOL, 18 which aligns with a recent systematic review identifying the beneficial effects of physical rehabilitation in cancer survivorship 44 . And a self‐help exercises program suggested that dysphagia‐related QOL may improve modestly, even among long‐term survivors 16 .…”

Section: Discussionmentioning

confidence: 74%

Interventions for head and neck cancer survivors: Systematic review

et al. 2022

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Background Interventions for head/neck cancer (HNC) survivors may not address their cancer‐related and general health needs. Methods Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA) guided this systematic review of studies from 2000 to 2021 of interventions targeting cancer survivors treated with curative‐intent, using MEDLINE, Embase, Emcare, and PsycINFO. Interventions were categorized into domains of the Quality of Cancer Survivorship Care Framework to characterize the scope and quality of interventions. Results We identified 28 studies for inclusion: 13 randomized and 15 non‐randomized. Most targeted surveillance/management of physical effects (n = 24) including 13 that also targeted psychosocial effects. Four studies addressed prevention/surveillance for recurrence/new cancers, one addressed health promotion/disease prevention, and one addressed chronic medical conditions. Most studies (n = 27) had medium‐high risk of bias. Conclusions There are few high‐quality studies addressing HNC survivorship. Future rigorously designed studies should address broader areas of care, including chronic disease management and health promotion/disease prevention.

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“…Furthermore, a direct relationship has been established between this symptomatic improvement and an improvement in terms of dependency. Analyzing the existing literature, we can see how this correlates directly with studies by Campbell, Covington or Sleight and his collaborators [43][44][45].…”

Section: Discussionmentioning

confidence: 78%

Multimodal physical exercise and functional rehabilitation program in oncological patients with cancer-related fatigue. A randomized clinical trial

Rodríguez

Gómez

Hernández

et al. 2022

Preprint

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Background The increase in life expectancy and survival time implies an increase in the possible side-effects of pharmacological treatments in these patients. Cancer-related fatigue is one of them. The main objective of this study is to evaluate the effects of a multimodal program of physical exercise and functional rehabilitation on asthenia, pain, functional capacity and quality of life in cancer patients with cancer-related fatigue. Methods This was a randomized, parallel-controlled clinical trial, with two arms (experimental and control group), and it was conducted over the course of a year in the Oncology Hospitalization Unit at the CAUSA. Participants were assessed at three points during the study. First assessment was prior to hospital discharge, second assessment was after 15 days, and final assessment was at one-month post-hospital follow-up. The main variables to be studied are the dependency levels (Barthel), cancer-related fatigue (FACT-An), health-related quality of life (EuroQoL-5D), functional capacity (SPPB) and kinesiophobia (TSK-F). Results Sample size (n = 44). Mean age 63.46 ± 12.36 years. Significant differences between control and experimental group participants in Barthel, FACT-An, TSK-F and SPPB scores (p = 0.000) at follow-up and final assessment. Conclusions There are beneficial effects of a multimodal physical exercise and functional rehabilitation program in improving the autonomy of cancer-related fatigue patients. Trials registration: The clinical trial was registered in ClinicalTrials.gov (NCT04761289). (18/02/2021). https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S000AP1U&selectaction=Edit&uid=U0004OJ7&ts=2&cx=bz92lb

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Systematic Review of Functional Outcomes in Cancer Rehabilitation

Cited by 44 publications

References 359 publications

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Integrating molecular biomarkers in breast cancer rehabilitation. What is the current evidence? A systematic review of randomized controlled trials

Interventions for head and neck cancer survivors: Systematic review

Multimodal physical exercise and functional rehabilitation program in oncological patients with cancer-related fatigue. A randomized clinical trial

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