Systematic review and meta-analysis on <i>Schistosoma mansoni</i> infection prevalence, and associated risk factors in Brazil

Casavechia, Maria Teresinha Gomes; Melo, Gessilda de Alcântara Nogueira de; Fernandes, Andréa Claudia Bekner da Silva; Castro, Kárin Reinhold de; Pedroso, Raíssa Bocchi; Santos, Thaís da Silva; Teixeira, Jorge Juarez Vieira

doi:10.1017/s0031182017002268

Cited by 30 publications

(20 citation statements)

References 60 publications

(112 reference statements)

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“…This shows an endemicity and moderate prevalence of S. mansoni infection found in Ethiopia [101]. This is comparable with meta-analysis studies conducted in Brazil [102]. However, this finding is higher than the pooled stool S S.mansoni estimated from migrants [103].…”

Section: Discussionsupporting

confidence: 82%

Prevalence ofSchistosoma mansoniinfection in Ethiopia: A systematic review and meta-analysis

Hussen¹,

Fenta²,

Shimelis³

2019

Preprint

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Background Schistosomiasis is the most predominant helminthic infection in tropics and subtropics mainly in sub-Saharan African countries including Ethiopia. S. mansoni infection is still becoming a public health problem since the risk of reinfection and recurrent disease remain, even in areas with high treatment coverage. There is no summarized data regarding prevalence of S. mansoni infection in Ethiopia. Therefore, this review was done to determine the pooled prevalence of S. mansoni infection in Ethiopia. Methods:The PRISMA guidelines protocol was followed to perform the systematic review and meta-analysis.Results: Eighty four studies were included in this review and meta-analysis. The pooled prevalence of S. mansoni among Ethiopian population was 18.7% (95%CI: 14.7-23.5). Southern regions of Ethiopia had a higher S.mansoni prevalence of 33.6% 995% CI: 20.2-50.4). S.mansoni was higher in rural areas and among males with a pooled prevalence, 20.8% (95% CI: 14.2-29.4) and 29.4% (95%CI: 23.2-36.6), respectively. Similarly, the prevalence of S.mansoni have been increased over the past 15 years. Conclusion:The review showed a moderate prevalence of S.mansoni infection in Ethiopia and disease is still a major health problem. Therefore, integrated control approach could be implemented to reduce the burden of this parasite in Ethiopia. Interventions leading to reduction of open water sources exposure to reduce schistosomiasis transmission, strengthen of deworming program, giving appropriate health education on the risk of schistosomal infection and transmission should be applied. from Medline, PubMed, Google scholar, HINARI and Cochrane Library. Eighty four studies were included in this review and meta-analysis. The limit of language was English and the limit of study group was human. The pooled prevalence of S. mansoni among Ethiopian population was 18.7%. Southern regions of Ethiopia had a higher S.mansoni prevalence and the parasite was higher in rural areas and among males. The prevalence of S.mansoni have been increased over the past 15 years. Our review showed a moderate prevalence of S.mansoni infection in Ethiopia and disease is still a major health problem. Therefore, appropriate controlling approach could be implemented. Interventions leadingto reduction of open water sources, strengthen of deworming program, and giving appropriate health education should be applied.

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Section: Discussionsupporting

confidence: 82%

Prevalence ofSchistosoma mansoniinfection in Ethiopia: A systematic review and meta-analysis

Hussen¹,

Fenta²,

Shimelis³

2019

Preprint

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“…A reduction in disease transmission was observed in all studies that examined prevalence after the implementation of monitoring programs. However, although there was a reduction, the disease transmission remained active in all the analyzed sites [34].…”

Section: Plos Onementioning

confidence: 92%

The influence of the age-period-cohort effects on the temporal trend mortality from schistosomiasis in Brazil from 1980 to 2014

2020

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Background Schistosomiasis is highly debilitating and related to poverty, leading to chronic health problems. This disease is important for public health due to the high prevalence, severity of clinical forms and heterogeneous spatial and temporal patterns. In Brazil, about 1.5 million people are at risk of infection with Schistosoma mansoni, with an annual average of 500 deaths. In this study, the temporal change in mortality was evaluated in relation to the effects of age, period and birth cohort, in Brazil and regions, from 1980 to 2014. Methods In this study, we analyzed the influence of age, period and birth cohort (APC effects) on the temporal evolution of schistosomiasis mortality in Brazil from 1980 to 2014, according to sex and geographic regions of the country. The death records were extracted from the SIM (Mortality Information System) of the DATASUS website (Department of National Health Informatics) of the Ministry of Health of Brazil. The temporal effects were estimated using Bayesian models and the INLA (Integrated Nested Laplace Approximations) method for parameter inference. Results More than 24 thousand deaths were registered in the analyzed period, mainly in men from the Northeast region. In Brazil, children under 14 years of age had protection against death from schistosomiasis. There was no significant effect for others ages. From 1990 to 1999, there was a protective effect for death from schistosomiasis and a null effect in the other periods. There was a decreasing trend in the risk of death among birth cohorts. The greatest risk was among people born from 1903 to 1912. There was a protective effect for death among people born after 1968. Men were at risk of death between 25 and 54 years old, while women were at risk after seventy years of age. The southern and central-western regions had a risk of death until 1989 and had a protective effect between1995 and 1999.

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“…In America, it is estimated that 1 to 3 million people are infected by S. mansoni and over 25 million live in risk areas, being Brazil and Venezuela the most affected (Zoni et al, 2016). The prevalence of this disease is correlated to social–economic and environmental factors (Gomes Casavechia et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Weighted Gene Co-Expression Analyses Point to Long Non-Coding RNA Hub Genes at Different Schistosoma mansoni Life-Cycle Stages

et al. 2019

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Long non-coding RNAs (lncRNAs) (>200 nt) are expressed at levels lower than those of the protein-coding mRNAs, and in all eukaryotic model species where they have been characterized, they are transcribed from thousands of different genomic loci. In humans, some four dozen lncRNAs have been studied in detail, and they have been shown to play important roles in transcriptional regulation, acting in conjunction with transcription factors and epigenetic marks to modulate the tissue-type specific programs of transcriptional gene activation and repression. In Schistosoma mansoni, around 10,000 lncRNAs have been identified in previous works. However, the limited number of RNA-sequencing (RNA-seq) libraries that had been previously assessed, together with the use of old and incomplete versions of the S. mansoni genome and protein-coding transcriptome annotations, have hampered the identification of all lncRNAs expressed in the parasite. Here we have used 633 publicly available S. mansoni RNA-seq libraries from whole worms at different stages (n = 121), from isolated tissues (n = 24), from cell-populations (n = 81), and from single-cells (n = 407). We have assembled a set of 16,583 lncRNA transcripts originated from 10,024 genes, of which 11,022 are novel S. mansoni lncRNA transcripts, whereas the remaining 5,561 transcripts comprise 120 lncRNAs that are identical to and 5,441 lncRNAs that have gene overlap with S. mansoni lncRNAs already reported in previous works. Most importantly, our more stringent assembly and filtering pipeline has identified and removed a set of 4,293 lncRNA transcripts from previous publications that were in fact derived from partially processed mRNAs with intron retention. We have used weighted gene co-expression network analyses and identified 15 different gene co-expression modules. Each parasite life-cycle stage has at least one highly correlated gene co-expression module, and each module is comprised of hundreds to thousands lncRNAs and mRNAs having correlated co-expression patterns at different stages. Inspection of the top most highly connected genes within the modules’ networks has shown that different lncRNAs are hub genes at different life-cycle stages, being among the most promising candidate lncRNAs to be further explored for functional characterization.

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Systematic review and meta-analysis on Schistosoma mansoni infection prevalence, and associated risk factors in Brazil

Cited by 30 publications

References 60 publications

Prevalence ofSchistosoma mansoniinfection in Ethiopia: A systematic review and meta-analysis

Prevalence ofSchistosoma mansoniinfection in Ethiopia: A systematic review and meta-analysis

The influence of the age-period-cohort effects on the temporal trend mortality from schistosomiasis in Brazil from 1980 to 2014

Weighted Gene Co-Expression Analyses Point to Long Non-Coding RNA Hub Genes at Different Schistosoma mansoni Life-Cycle Stages

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