Systematic Review and Meta-Analysis of COVID-19 Vaccination Acceptance

Abstract

IntroductionVaccination is an essential intervention to curb the coronavirus disease 2019 (COVID-19) pandemic. This review aimed to estimate the pooled proportion of COVID-19 vaccine acceptance worldwide.MethodsA systematic search of the MEDLINE (PubMed) database using “COVID-19,” “vaccine” and “acceptance” to obtain original research articles published between 2020 and July 2021. Only studies with full text and that were published in English were included. The Joanna Briggs Institute meta-analysis was used to assess the data quality. The meta-analysis was performed using generic inverse variance with a random-effects model using the Review Manager software.ResultsA total of 172 studies across 50 countries worldwide were included. Subgroup analyses were performed with regard to vaccine acceptance, regions, population, gender, vaccine effectiveness, and survey time. The pooled proportion of COVID-19 vaccine acceptance was 61% (95% CI: 59, 64). It was higher in Southeast Asia, among healthcare workers, in males, for vaccines with 95% effectiveness, and during the first survey.ConclusionCOVID-19 vaccine acceptance needs to be increased to achieve herd immunity to protect the population from the disease. It is crucial to enhance public awareness of COVID-19 vaccination and improve access to vaccines.Systematic Review RegistrationPROSPERO 2021, identifier CRD42021268645.

COVID-19 Vaccination: An Exploratory Study of the Motivations and Concerns Detailed in the Medical Records of a Regional Australian Population

“…The core concept of “uncertainty” in our study captured various aspects of uncertainty related to COVID-19 vaccination identified in previous studies [ 39 , 40 , 41 ], including the speed of development, perceived lack of sufficient testing, and long-term side effects. Past research comparing three hypothetical vaccine scenarios of vaccines being approved in one week, one year, or in two years, found that the shortest-term scenario was associated with significantly lower perceived vaccine efficacy and higher vaccine risks than the longer duration scenarios [ 40 ].…”

“…Insufficient evidence for COVID-19 vaccine effectiveness was identified as a leading reason for reduced confidence in vaccines among the general population identified in a systematic review and meta-analysis of 172 studies of approx. 800,000 people from 50 countries [ 41 ]. These uncertainties relate to individual risk perception via “ambiguity aversion”, where risks are avoided when the outcome is uncertain [ 34 ].…”

Acceptance towards COVID-19 vaccination in Latin America and the Caribbean: A systematic review and meta-analysis

“…Despite the rapid vaccine development process and implementation of vaccination campaigns against COVID-19, vaccination acceptance continues to be a challenge for health authorities [ 5 ]. Previous systematic reviews have found global vaccination acceptance rates ranging from 61 to 73% [ 6 , 7 ]. Also, these reviews highlight the great variability in vaccination acceptance rates depending on the geographic location.…”

“…For that reason, information on vaccine acceptance rates and its distribution across different population subgroups is needed. However, currently available reviews that synthetize vaccination acceptance rates mainly include studies from Europe and North America [ 6 , 7 ]. This could be explained by the databases used to conduct the search and the language restrictions when including the individual studies.…”

How Implicit Attitudes toward Vaccination Affect Vaccine Hesitancy and Behaviour: Developing and Validating the V-IRAP

“…Meanwhile, healthcare personnel who were not directly in contact with these patients reported greater hesitancy. However, a generally higher acceptance of vaccination among healthcare workers with respect to the general population was reported in the literature [ 25 ].…”