Systematic review and meta-analysis of epidemiologic data on vaccine response in relation to exposure to five principal perfluoroalkyl substances

Crawford, Lori; Halperin, Scott A.; Dzierlenga, Michael W.; Skidmore, Becky; Linakis, Matthew W.; Nakagawa, Shinichi; Longnecker, Matthew P.

doi:10.1016/j.envint.2023.107734

Cited by 26 publications

(10 citation statements)

References 57 publications

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“…56 Additionally, PFAS have also been associated with decreased vaccine response in children; however, we do not know of any studies evaluating the serum or plasma metabolome and decreased vaccine response in children, specifically using untargeted metabolomics. 14 Regardless, future studies could evaluate the metabolome as a mediator for the PFAS−vaccine response association.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…As PFAS have been consistently associated with adverse birthweight, future studies could examine the prenatal or infant metabolome as a mediator of associations between PFAS and adverse birth outcomes . Additionally, PFAS have also been associated with decreased vaccine response in children; however, we do not know of any studies evaluating the serum or plasma metabolome and decreased vaccine response in children, specifically using untargeted metabolomics . Regardless, future studies could evaluate the metabolome as a mediator for the PFAS–vaccine response association.…”

Section: Resultsmentioning

confidence: 99%

“…Prenatal exposure to individuals and mixtures of PFAS has been associated with reduced birthweight, preterm birth, decreased vaccine response in children, and unfavorable cardiometabolic outcomes. ,− Yet, the mechanisms by which PFAS exposure leads to these conditions are unclear. Thus, studies are needed to investigate the range of biological pathways with which PFAS interact to provide insight into the array of adverse health effects associated with PFAS exposures.…”

Section: Introductionmentioning

confidence: 99%

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Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study

Hall,

Fleury,

Papandonatos

et al. 2023

Environ. Sci. Technol.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study

Hall,

Fleury,

Papandonatos

et al. 2023

Environ. Sci. Technol.

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“…The health advisory values proposed by the U.S. EPA reflect the studies that show a disruption of the immune system for children (measured by a decreased response to vaccination for children) as well as disruption of lipid metabolism (affecting cholesterol levels in blood). A recent systematic review and meta-analysis of the epidemiological literature on PFAS and vaccine response concluded that the five principal PFAS are associated with reduced antibody levels for different antigens . Much of the movement to reinforce regulatory limits of PFAS rests on how the U.S. EPA has interpreted the immunotoxicological data for the lower vaccination response.…”

Section: Pfas In Drinking Watermentioning

confidence: 99%

How Should We Interpret the New Water Quality Regulations for Per- and Polyfluoroalkyl Substances?

Sauvé,

Barbeau,

Bouchard

et al. 2023

ACS EST Water

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Water quality regulations for per-and polyfluoroalkyl substances (PFAS) are currently in turmoil given the toxicological evidence of human health effects at background levels of exposure. Many countries are currently considering regulating the usage of PFAS as a group while also lowering the water quality standards for drinking water. It is somewhat disconcerting that different countries have different approaches to regulate PFAS in drinking water, focusing either on specific PFAS targets (such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS)) or on larger groups of PFAS ranging from 12 to roughly 30 target PFAS compounds. Considering that there are between 5000 and over 10 000 estimated potential PFAS compounds and that they may transform into one another in the environment, this poses significant regulatory challenges and may cause incoherent regulations across various jurisdictions. Regulatory policies for drinking water have evolved much more rapidly than other pathways of exposure, i.e., food, soil, dust, and atmospheric exposure. We must ensure that proposed regulations are coherent to minimize exposure and risks and that remediation approaches are balanced to reduce overall exposure across the various sources of exposure.

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“…Given their persistence, blood levels of some PFAS may increase over long periods of time [14]. Increasing epidemiologic research has suggested that exposure to high levels of PFAS might be associated with many adverse health conditions, including decreased fertility in men [15] and women [14], birth defects [16], delayed development [17], osteoporosis in young men [18], damage to the immune system [19], reduced antibody response after vaccination, allergy and asthma in children [20], liver disease [21], increased levels of serum cholesterol [22], impaired thyroid function [23], insulin resistance [24], gestational diabetes [25], pregnancy-induced hypertension [26], neuro-endocrine disruption [27] and cancer.…”

Section: Introductionmentioning

confidence: 99%

All-cause, circulatory disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980-2018)

Biggeri,

Stoppa,

Facciolo

et al. 2023

Preprint

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BackgroundPerfluoroalkyl substances (PFAS) are associated with many adverse health conditions. Among the main effects is carcinogenicity in humans, which deserves to be further clarified. A clear association has been reported for kidney cancer and testicular cancer. In 2013, a large episode of surface, ground and drinking water contamination with PFAS was uncovered in three provinces of the Veneto Region (north-eastern Italy) involving 30 municipalities and a population of about 150,000. We report on the temporal evolution of all-cause mortality and selected cause-specific mortality by calendar period and birth cohort in the local population between 1980 and 2018.MethodsThe Italian National Institute of Health and the Italian National Institute of Statistics made available the anonymous records of death certificates of residents of the provinces of Vicenza, Verona and Padova (males, n=29,629; females, n=29,518) who died between 1980 and 2018. Calendar period analysis was done by calculating standardized (European standard population 2013) mortality ratios using the total population of the three provinces in the same calendar period as a reference. The birth cohort analysis was performed using cumulative risks for ages 20-84 years.ResultsDuring the 33 years between 1985 (assumed as beginning date of water contamination) and 2018 (last year of available cause-specific mortality), in the resident population of theRed area(the municipalities being connect to the contaminated water plant) we observed 51,621 deaths as compared to 47,731 expected (age-sex SMR: 108; 90% CI: 107-109). We found evidence of raised mortality for diseases of the circulatory system (in particular, heart disease and ischemic heart disease) and malignant neoplastic diseases, including kidney cancer and testicular cancer.ConclusionsFor the first time, an association of PFAS exposure with mortality from circulatory disease mortality was formally demonstrated. Circumstantial evidence regarding kidney cancer and testicular cancer is consistent with previously reported data.

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Systematic review and meta-analysis of epidemiologic data on vaccine response in relation to exposure to five principal perfluoroalkyl substances

Cited by 26 publications

References 57 publications

Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study

Associations of a Prenatal Serum Per- and Polyfluoroalkyl Substance Mixture with the Cord Serum Metabolome in the HOME Study

How Should We Interpret the New Water Quality Regulations for Per- and Polyfluoroalkyl Substances?

All-cause, circulatory disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980-2018)

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