Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Truong, Lisa; Zaikova, Tatiana; Baldock, Brandi L.; Balik-Meisner, Michele R; To, Kimberly; Reif, David M.; Kennedy, Zachary C.; Hutchison, James E.; Tanguay, Robert L.

doi:10.1080/17435390.2019.1592259

Cited by 24 publications

(19 citation statements)

References 65 publications

(88 reference statements)

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“…ENM surface area has been linked to overall toxic response, with the most notable reasoning being the availability of a larger surface area for interactions when the mass per volume is held constant (Lee et al, 2018;Truong et al, 2019). We observe that the two ENM with the highest surface area, 1%Ag-SiO 2 and 10%Ag-SiO 2 exhibit the highest toxicity values.…”

Section: Variable Wagge Responses Across Pcc Reveal Intricate Characteristic Interactions For Toxicity Responsementioning

confidence: 82%

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Truong

Edwards

et al. 2019

NanoImpact

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Despite the increasing prevalence of engineered nanomaterials (ENMs) in consumer products, their toxicity profiles remain to be elucidated. ENM physicochemical characteristics (PCC) are known to influence ENM behavior, however the mechanisms of these effects have not been quantified. Further confounding the question of how the PCC influence behavior is the inclusion of structural and molecular descriptors in modeling schema that minimize the effects of PCC on the toxicological endpoints. In this work, we analyze ENM physico-chemical measurements that have not previously been studied within a developmental toxicity framework using an embryonic zebrafish model. In testing a panel of diverse ENMs to build a consensus model, we found nonlinear relationships between any singular PCC and bioactivity. By using a machine learning (ML) method to characterize the information content of combinatorial PCC sets, we found that concentration, surface area, shape, and polydispersity can accurately capture the developmental toxicity profile of ENMs with consideration to whole-organism effects.

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Section: Variable Wagge Responses Across Pcc Reveal Intricate Characteristic Interactions For Toxicity Responsementioning

confidence: 82%

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Truong

Edwards

et al. 2019

NanoImpact

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“…Zebrafish exposure to solid pigments analysis followed analysis in Troung et al [ 63 ]. Embryo Photomotor Response (EPR) behavior was analyzed by comparing the background, excitatory, and refractory intervals to the negative control (0 μg/mL of compound) activity using a combination of percent change and a Kolmogorov–Smirnov test (Bonferroni-corrected p -value threshold).…”

Section: Methodsmentioning

confidence: 99%

“…Concentration response modeling based on mortality and morphology data was carried out on mortality data at 24 hpf and at 120 hpf for tested compounds showing significant responses compared to the control. R was used to fit a Hill model to the average of all individuals at each exposure concentration following methods in Truong et al [ 63 ], using the four parameters of lower limit, upper limit, the median effective concentration (EC50) curve inflection point, and the “Hill” slope. Curves were fit with the drm() function in drc package in R, using least squares estimation.…”

Section: Methodsmentioning

confidence: 99%

Preliminary Examination of the Toxicity of Spalting Fungal Pigments: A Comparison between Extraction Methods

Almurshidi

Court

Gutierrez

et al. 2021

JoF

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Spalting fungal pigments have shown potential in technologies ranging from green energy generation to natural colorants. However, their unknown toxicity has been a barrier to industrial adoption. In order to gain an understanding of the safety of the pigments, zebrafish embryos were exposed to multiple forms of liquid media and solvent-extracted pigments with concentrations of purified pigment ranging from 0 to 50 mM from Chlorociboria aeruginosa, Chlorociboria aeruginascens, and Scytalidium cuboideum. Purified xylindein from Chlorociboria sp. did not show toxicity at any tested concentration, while the red pigment dramada from S. cuboideum was only associated with significant toxicity above 23.2 uM. However, liquid cultures and pigment extracted into dichloromethane (DCM) showed toxicity, suggesting the co-production of bioactive secondary metabolites. Future research on purification and the bioavailability of the red dramada pigment will be important to identify appropriate use; however, purified forms of the blue-green pigment xylindein are likely safe for use across industries. This opens the door to the adoption of green technologies based on these pigments, with potential to replace synthetic colorants and less stable natural pigments.

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“…A theme commonly addressed in these studies has been the nature of the relationships between different characteristics and toxicity/bioaccumulation. NM properties have been shown to influence toxicity in case studies with NM sets varying in their compositional chemistry, [ 2,3 ] size [ 4–6 ] and surface coating/charge, [ 7–9 ] allowing potential relationship between measurable structural particle properties and hazard to be proposed. However, not all such studies with differing NMs have found such relationships.…”

Section: Introductionmentioning

confidence: 99%

Nanomaterial Transformations in the Environment: Effects of Changing Exposure Forms on Bioaccumulation and Toxicity

Spurgeon

Lahive

Schultz

2020

Small

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In the environment, nanomaterials (NMs) are subject to chemical transformations, such as redox reactions, dissolution, coating degradation, and organic matter, protein, and macromolecule binding, and physical transformations including homo or heteroagglomeration. The combination of these reactions can result in NMs with differing characteristics progressing through a functional fate pathway that leads to the formation of transformed NM functional fate groups with shared properties. To establish the nature of such effects of transformation on NMs, four main types of studies are conducted: 1) chemical aging for transformation of pristine NMs; 2) manipulation of test media to change NM surface properties; 3) aging of pristine NMs water, sediment, or soil; 4) NM aging in waste streams and natural environments. From these studies a paradigm of aging effects on NM uptake and toxicity can be developed. Transformation, especially speciation changes, largely results in reduced potency. Further reactions at the surface resulting in processes, such as ecocorona formation and heteroagglomeration may additionally reduce NM potency. When NMs of differing potency transform and enter environments, common transformation reaction occurring in receiving system may act to reduce the variation in hazard between different initial NMs leading to similar actual hazard under realistic exposure conditions.

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Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Abstract: Systematic determination of the relationship between nanoparticle core diameter and toxicity for a series of structurally analogous gold nanoparticles in zebrafish

Cited by 24 publications

References 65 publications

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Multivariate modeling of engineered nanomaterial features associated with developmental toxicity

Preliminary Examination of the Toxicity of Spalting Fungal Pigments: A Comparison between Extraction Methods

Nanomaterial Transformations in the Environment: Effects of Changing Exposure Forms on Bioaccumulation and Toxicity

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