System of Hemopoiesis and Morphogenesis

Yushkov, B. G.; Chereshnev, V. А.; Tyumentseva, N. V.; Artashyan, O. S.; Kuz'min, A. I.

doi:10.1007/s10517-006-0040-4

Cited by 1 publication

(3 citation statements)

References 6 publications

(5 reference statements)

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“…The main pathway of MC activation under stress remains unclear. First, catecholamines produced by activation of the sympathoadrenal system directly affect MCs through adrenergic receptors [12], and thymus MCs are known to establish connections with catecholaminergic nerve terminals. Second, corticotropin-releasing hormone produced by the hypothalamus affects MC by binding to the KRG-Rl receptor, resulting in the release of histamine, which leads to increased permeability and vasodilation [1].…”

Section: Resultsmentioning

confidence: 99%

“…25, № 3 interactions, permeability of the hematothymic barrier, and migration of thymus lymphocytes through the production of IL-1, IL-2, IL-3, IL-4, IL-6, TNFα, GM-CSF, NGF [4,6,10]. Additionally, it is assumed that thymus is the place of formation and deposit of MCs [8,12]. In this regard, MCs can play an important role in the process of acute transformation of the thymus, affecting the extratimic migration of cells during the development of the stress reaction.…”

Section: тучные клетки тимуса и стрессmentioning

confidence: 99%

“…Acute thymus involution is known to be a manifestation of adaptation syndrome in response to stress. Under stress, the level of thymus polypeptides increases, which limits the stressdamaging effect of hypothalamic-pituitary-adrenal axis excessive activity [12]. In this case, the content of lymphoid cells in the thymus is reduced, and the number of epithelioreticulocytes and degenerating cells is increased.…”

Section: Introductionmentioning

confidence: 99%

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Thymus mast cells as a component of neuro-endocrine-immune interactions under stress

Artashyan

Khramtsova

2023

Med. immunol.

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Mast cells (MCs) are a required component of the thymus microenvironment. They affect intercellular interactions and permeability of the hematothymic barrier through cytokine production. There is speculation that the thymus is the site of MCs formation and deposition. MCs are under complex neuro-endocrine control and they can play an important role in the process of acute transformation of the thymus in the formation of a stress reaction, affecting the extrathymic migration of cells. The purpose of this study is to assess the functional involvement of MCs in the process of the thymus acute transformation at various hyper- and hypodynamic effects during the formation of stress response and without it.The study was conducted on male Wistar rats. The stress factors were physical activity (swimming) of different intensities and immobilization, which represent two opposite states of dynamic stress. MCs were classified on histological preparations; a degranulation coefficient and a mean histochemical coefficient (synthetic activity) were calculated.In groups with preserved adrenal glands after exposure a significant decrease in the thymus mass coefficient is noted, which indicates a weakening of its functional activity in response to the development of stress. At the same time, MCs of the thymus quickly respond to neuro-endocrine factors under stress. These cells are involved in a general reaction: their activity consists in a synchronous decrease of the synthesis of granules in the cytoplasm and an increased release of active substances accumulated earlier. The mass and structure of the thymus remain unchanged in groups with removed adrenal glands after immobilization. No changes in morphofunctional indicators of mast cells were detected either. Experiments with hypo- and hyperdinamic loading of animals with preserved and removed adrenal glands indicate that the MCs response is largely determined by the hypothalamic-pituitary-adrenal axis of the endocrine system. Removal of the adrenal glands (inability to release glucocorticoids) leads to a lack of functional response from the thymus MCs. The stimulating effect of adrenal glucocorticoids on MCs under stress is carried out in combination with other neuro-endocrine factors (catecholamines, corticotropin-releasing hormone, adrenocorticotropic hormone). When this axis is activated and a full-fledged stress reaction is formed by the body, MCs are actively involved in the process of acute transformation of the thymus through cytokine secretion. These is an important condition for the development of adaptation mechanisms by the immune system.

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Section: Resultsmentioning

confidence: 99%