Syrup of Ipecac—A Slow or Fast Emetic?

The Treatment of Salicylate Poisoning Using Mannitol and Forced Alkaline Diuresis

“…The experimental work of Arnold, Hodges & Barta (1959) suggested that induced emesis was the most effective method of emptying the stomach of aspirin, and that syrup of ipecacuanha was a suitable agent. Our experience has confirmed the favourable reports of other workers (Robertson, 1962;Dabbous, Bergman & Robertson, 1965;Marsh, 1966;Shirkey, 1966). The average time between administration of ipecacuanha and emesis was 30 min and only two patients failed to vomit within the hour.…”

Amazonian useful plants described in the book “Le Pays des Amazones” (1885) of the Brazilian propagandist Baron de Santa-Anna Nery: a historical and ethnobotanical perspective

“…Willd.) ipecacuanha, poaia 104 Not mentioned Native Emetic, expectorant, diaphoretic (sudorific) Expectorant † [ 131 ], emetic † [ 132 , 133 ], immunomodulatory [ 134 ] Genipa americana L. (= Genipa brasiliensis (Sprend.) Baill) jenipapo 106 Fruit Native Medicinal (undefined) Antiplatelet, anti-inflammatory [ 135 ]; neuroprotective [ 136 ]; antioxidant, anti-glycant [ 137 ]; antithrombotic [ 138 ]; anticonvulsant [ 139 ]; trypanocidal [ 140 ] Sapindaceae Paullinia cupana Kunth.…”

Clinical Pharmacokinetics of Oral Activated Charcoal in Acute Intoxications

“…High doses of ipecac syrup given with water cause emesis in about 90% of intoxicated patients, with a mean delay of 20 to 30 minutes. In most patients ipecac syrup seems to induce emesis despite the previous ingestion of antiemetics, but failures or serious delays, resulting in a considerable absorption of drugs, may occur (Karlsson and Noren, 1965;Manoguerra and Krenzelok, 1978;Robertson, 1962;Volans, 1981). Ifactivated charcoal and ipecac syrup are used concomitantly, ipecac should be given first, and, in general, not until it has induced vomiting should activated charcoal be added.…”