Syphilitic meningitis in HIV-patients with meningeal syndrome: report of two cases and review

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

“…However, a variety of presentations can occur. An increased frequency of ophthalmologic alterations as well as accelerated late manifestations of neurosyphilis have been described 4,15 . Two patients with confirmed neurosyphilis presented headache without an associated meningeal syndrome.…”

One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases

“…Instead, it is typically based on a combination of clinical evaluation and analysis of CSF findings. CSF VDRL, CSF treponemal tests, CSF pleocytosis, and CSF protein levels should be evaluated [113].…”

“…Syphilis is a serious infectious disease, which can damage multiple organ systems and present with various clinical presentations [109][110][111]. In 4-9% of patients infected with syphilis (Traponema pallidum) and left untreated, neurosyphilis (NS) might develop as the consequence of involvement of the central nervous system [112,113]. The disease can either be asymptomatic or might present with multiple neurological and psychiatric symptoms such as seizures, ocular disorders, psychiatric/behavioral changes, and less likely tabes dorsalis or general paresis [114].…”

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

“…However, a variety of presentations can occur. An increased frequency of ophthalmologic alterations as well as accelerated late manifestations of neurosyphilis have been described 4,15 . Two patients with confirmed neurosyphilis presented headache without an associated meningeal syndrome.…”

One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases

“…Instead, it is typically based on a combination of clinical evaluation and analysis of CSF findings. CSF VDRL, CSF treponemal tests, CSF pleocytosis, and CSF protein levels should be evaluated [113].…”

“…Syphilis is a serious infectious disease, which can damage multiple organ systems and present with various clinical presentations [109][110][111]. In 4-9% of patients infected with syphilis (Traponema pallidum) and left untreated, neurosyphilis (NS) might develop as the consequence of involvement of the central nervous system [112,113]. The disease can either be asymptomatic or might present with multiple neurological and psychiatric symptoms such as seizures, ocular disorders, psychiatric/behavioral changes, and less likely tabes dorsalis or general paresis [114].…”

Disruption of microglia histone acetylation and protein pathways in mice exhibiting inflammation-associated depression-like symptoms

“…NCL interacts with protein p42IP4/centaurin-alpha 1 in the brains of Alzheimer’s patients that often exhibit depression comorbidity (Reiser and Bernstein, 2004). Likewise, ACTN1 is differentially expressed in the frontal cortex of patients diagnosed with HIV and meningitis (Selvan et al, 2015) and these conditions exhibit depression comorbidity (Carmo et al, 2001).…”

Clinical characteristics and evolution of syphilis in 24 HIV+ individuals in Rio de Janeiro, Brazil

“…However, a variety of presentations can occur. An increased frequency of ophthalmologic alterations as well as accelerated late manifestations of neurosyphilis have been described 4,15 . Two patients with confirmed neurosyphilis presented headache without an associated meningeal syndrome.…”

One Patient, Three Providers: A Multidisciplinary Approach to Managing Common Neuropsychiatric Cases

“…Instead, it is typically based on a combination of clinical evaluation and analysis of CSF findings. CSF VDRL, CSF treponemal tests, CSF pleocytosis, and CSF protein levels should be evaluated [113].…”

“…Syphilis is a serious infectious disease, which can damage multiple organ systems and present with various clinical presentations [109][110][111]. In 4-9% of patients infected with syphilis (Traponema pallidum) and left untreated, neurosyphilis (NS) might develop as the consequence of involvement of the central nervous system [112,113]. The disease can either be asymptomatic or might present with multiple neurological and psychiatric symptoms such as seizures, ocular disorders, psychiatric/behavioral changes, and less likely tabes dorsalis or general paresis [114].…”