Syphilis serology today

Felman, Yehudi M.

doi:10.1001/archderm.116.1.84

Cited by 12 publications

(6 citation statements)

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“…Sensitivity of the T. pallidum immobilization test is 41-56% in primary, 94-97% in secondary and 92-98% in late syphilis. The haemagglutination tests have sensitivity similar to that of the FTA-ABS, except in primary syphilis in which non reactivity occurs in up to 36% of cases [16]. False-positive results have been reported in auto-immune diseases, alcoholic cirrhosis, lymphosarcoma, vaccination and individuals with no evidence of any disease.…”

Section: Discussionmentioning

confidence: 87%

Otoneurosyphilis Masquerading as Neurofibromatosis Type II

Ahmad

Lee

1999

ORL

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We present a case report of a 75-year-old patient with bilateral sensorineural hearing loss, vertigo and progressive neurological deficits. MRI scans showed multiple intracranial lesions. In the light of positive serological tests for syphilis, these unusual radiological features might represent gummatous lesions which were in keeping with a diagnosis of tertiary syphilis with otological and neurological involvement. The patient was treated with Bicillin and corticosteroids with initial improvement, but succumbed rapidly with multiple neurological deficits. The radiological differential diagnosis included neurofibromatosis type II in this case, which illustrates that neurosyphilis can mimic other neurological diseases. The literature on neurosyphilis is reviewed.

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Section: Discussionmentioning

confidence: 87%

Otoneurosyphilis Masquerading as Neurofibromatosis Type II

Ahmad

Lee

1999

ORL

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“…Para a sífilis a prevalência calculada de 4,1% poderia ser considerada superestimada devido a inespecificidade do VDRL por ser uma reação não treponêmica com possibilidade de resultados falso positivos 11,24 . Por este motivo e pela instabilidade do resultado do teste a validação da prevalência torna-se bastante difícil.…”

Section: Resultsunclassified

Rastreamento sorológico para doenças infecciosas em banco de sangue como indicador de morbidade populacional

et al. 1989

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É discutido o valor do rastreamento sorológico para doença de Chagas, sífilis, hepatite B e AIDS realizado por bancos de sangue como indicador de morbidade populacional. Foram analisados os dados referentes a 62.814 doações de sangue obtidas em dois bancos de sangue públicos e três privados correspondendo ao total das doações no período de outubro de 1985 a outubro de 1987 em Goiânia, Goiás (Brasil). A soroprevalência foi comparada com dados obtidos pela notificação compulsória das doenças e com inquéritos epidemiológicos disponíveis. Foi encontrada soroprevalência para AIDS de 0,0@% para um único exame de ELISA, estimando-se em 1.900 o número de indivíduos supostamente infectados em Goiás, número compatível com o esperado quando se trabalha com dados de notificação. Para a doença de Chagas, hepatite B e sífilis foram observadas soroprevalências de até 3,3%, 1,3% e 4,1%, respectivamente. Foram discutidas as dificuldades encontradas para validação desses resultados pela ausência de notificação compulsória e características particulares dos inquéritos sorológicos.

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“…The apparent lack of utility of VDRL testing may be explained by the truly rare occurrence of cerebral neurosyphilis. However, the use of the VDRL test in screening for cases of late syphilis has been questioned, since up to one‐quarter of afflicted patients have a falsely negative result 11,12 . The FTA‐ABS test, with a reported sensitivity of 95 per cent, has been recommended as the preferable screening test in this setting 13 .…”

Section: Discussionmentioning

confidence: 99%

The Role of Lumbar Puncture in the Evaluation of Dementia: The Durham Veterans Administration/Duke University Study

Becker

Feussner

Mulrow

et al. 1985

J American Geriatrics Society

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The use of lumbar puncture (LP) and cerebrospinal fluid (CSF) analysis in the routine, initial evaluation of patients with dementia continues to be questioned. This is especially true in the investigation of infectious causes of dementia. To explore this question further, the authors performed a retrospective analysis of 672 hospitalized patients specifically evaluated for dementia. LP and CSF analysis were performed on 402 patients (60 per cent); routine bacteriologic, acid-fast, and fungal cultures were also obtained for 333 of these patients. Most patients were white (64 per cent) and male (63 per cent), their mean age being 66 +/- 11 years. Four patients were diagnosed as having meningitis--two with Cryptococcus neoformans, one with apparent Mycobacterium tuberculosis, and one with coagulase-positive Staphylococcus aureus. These patients were characterized by a subacute change in mental status, fever or meningismus, and CSF pleocytosis with abnormal CSF chemistries. None of the patients were found to have newly diagnosed neurosyphilis. The authors conclude that LP and CSF analysis should not be part of the routine evaluation of patients with dementia and should be performed only in the presence of such indications as a subacute duration of dementia, fever, and signs of meningeal irritation.

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Syphilis serology today

Cited by 12 publications

References 0 publications

Otoneurosyphilis Masquerading as Neurofibromatosis Type II

Otoneurosyphilis Masquerading as Neurofibromatosis Type II

Rastreamento sorológico para doenças infecciosas em banco de sangue como indicador de morbidade populacional

The Role of Lumbar Puncture in the Evaluation of Dementia: The Durham Veterans Administration/Duke University Study

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