Syphilis oculaire : étude rétrospective de 27 cas au CHU de Nantes (France) de 2000 à 2013

Carbonnière, C.; Couret, C.; Guillouzouic, A.; Lefèbvre, M.; Lebranchu, Pierre; Weber, M.

doi:10.1016/j.revmed.2015.07.008

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…Eye involvement may even present as the only sign of syphilis requiring treatment [4,8]. Any part of the eye may be affected [5,9]. Syphilis was only diagnosed based on the ophthalmologic symptoms in patients 2, 3, and 4.…”

Section: Discussionmentioning

confidence: 99%

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Ocular syphilis – a case series of four patients

Jahnke

Sunderkötter

Lange

et al. 2021

J Deutsche Derma Gesell

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Summary Ocular manifestations of syphilis with visual impairment symptoms may occur already at the stage of secondary syphilis. They may also be the only manifestation of syphilis and mimic other diseases of the eye. Therefore, in all patients with uveitis, optic neuritis, optic atrophy, acute ocular muscle paresis, or loss of visual acuity, syphilis infection should be ruled out, even if the medical history does not initially raise suspicion. Ocular involvement should be treated as neurosyphilis. Delayed diagnosis and inadequate therapy are often associated with irreversible consequences for the affected patient. As with any syphilis infection, HIV infection should be considered and excluded, especially in the case of ocular manifestations.

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Section: Discussionmentioning

confidence: 99%

“…Ocular symptoms associated with syphilis infection have been reported to occur in 0.6-2.7% of all cases [4][5][6][7]. It should be noted that eye involvement may occur within a few weeks after infection, in the stage of early syphilis.…”

Section: Discussionmentioning

confidence: 99%

Ocular syphilis – a case series of four patients

Jahnke

Sunderkötter

Lange

et al. 2021

J Deutsche Derma Gesell

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“…of years)No. of patients/year†Present seriesBrazil2442011–2013 (2)22Hoogewoud et al [24]France2662003–2016 (14)4.7Bollemeijer et al [15]Netherlands5851984–2013 (29)2.9Tsuboi et al [27]Japan1201997–2015 (18)1.1Zhang et al [16]China1152012–2015 (3)5Shen et al [28]China1132009–2014 (5)2.6Carbonnière et al [29]France1272000–2013 (13)2.1Lee et al [30]USA1162008–2014 (6)2.7Moradi et al [19]USA1351984–2014 (20)1.75Northey et al [17]Australia1252007–2012 (5)5Yap et al [31]Singapore1122004–2009 (5)2.4Fonollosa et al [14]Spain8502000–2012 (12)4.2Mathew et al [11]United KingdomNational412009–2011 (2)20.5Yang et al [10]China1192004–2011 (7)2.7Li et al [32]USA1131991–2009 (18)0.7Balaskas et al [13]Switzerland1261999–2009 (10)2.6Fonollosa et al [5]Spain2122005–2007 (2)6Anshu et al [6]Singapore1…”

Section: Discussionmentioning

confidence: 99%

The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis

Queiroz

Inês

Diligenti

et al. 2019

J Ophthal Inflamm Infect

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BackgroundSyphilitic uveitis is reemerging globally, may lead to any type of intraocular inflammation, and is potentially sight-threatening. We aim to characterize clinical features and prognostic factors in patients with syphilitic posterior uveitis.MethodsRetrospective chart review at two tertiary university-based referral centers in Brazil. Clinical data, laboratory results, and treatment outcomes were analyzed. Statistical analysis was performed using Fisher’s exact test for categorical variables and Mann-Whitney U test for continuous variables.ResultsForty-four patients (81 eyes) were consecutively diagnosed with syphilitic posterior uveitis between March 2011 and April 2013.Thirty-one were male (70.5%) and the mean age was 43.8 years (range 15–81). HIV confection was disclosed in 12 patients (29.3%). The most prevalent finding was vitritis (85.2%), followed by retinal involvement (76.4%) and optic disc abnormalities (63.5%). After treatment, mean visual acuity improved from 1.2 (20/320) to 0.6 (20/80; median 20/30), but 19 eyes (23.5%) persisted with ≤ 1.0 (20/200). Factors associated with final visual acuity ≤ 1.0 despite therapy were prior use of systemic corticosteroids (p = 0.001), higher Venereal Disease Research Laboratory titers (p = 0.004), longer duration of symptoms (p = 0.024), and worse initial VA (p < 0.001).ConclusionsSyphilitic uveitis is reemerging. Delayed diagnosis and inadvertent use of systemic corticosteroids are potentially modifiable prognostic factors to be considered for possibly improving outcomes.

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“…Sie kann auch einziger Hinweis einer behandlungsbedürftigen Syphilis sein [4, 8]. Die Manifestation kann an jedem Teil des Augenapparates stattfinden [5, 9]. Bei den Patienten 2, 3 und 4 wurde erst aufgrund der ophthalmologischen Symptomatik eine Syphilis gesichert.…”

Section: Diskussionunclassified

“…Okuläre Symptome im Zusammenhang mit einer Syphilis-Infektion wurden in 0,6-2,7% aller Fälle beschrieben [4][5][6][7]. Beachtenswert ist, dass eine Augenbeteiligung bereits wenige Wochen nach Infektion und somit im Stadium der Frühsyphilis möglich ist.…”

Section: Diskussionunclassified

Okuläre Syphilis – eine Fallserie von vier Patienten

Jahnke

Lange

Wienrich

et al. 2021

J Deutsche Derma Gesell

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Zusammenfassung Okuläre Manifestationen einer Syphilis mit Visus‐beeinträchtigenden Beschwerdebildern können sich bereits im Sekundärstadium der Erkrankung ereignen. Sie können auch die einzige Manifestation einer Syphilis sein und andere Erkrankungen des Auges imitieren. Daher sollte bei allen Patienten mit Uveitis, Optikusneuritis, Optikusatrophie, akut aufgetretener Augenmuskelparese beziehungsweise bei ungeklärtem Visusverlust eine Syphilisinfektion ausgeschlossen werden. Dies gilt auch, wenn die anamnestischen Angaben zunächst keine Verdachtsmomente liefern. Die okuläre Manifestation der Erkrankung sollte wie eine Neurosyphilis behandelt werden. Eine verzögerte Diagnosestellung und inadäquate Therapie gehen vielfach mit irreversiblen Folgen für den betroffenen Patienten einher. Grundsätzlich ist bei Auftreten einer Syphilis immer das Vorliegen einer assoziierten HIV‐Infektion zu überprüfen.

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Syphilis oculaire : étude rétrospective de 27 cas au CHU de Nantes (France) de 2000 à 2013

Cited by 11 publications

References 23 publications

Ocular syphilis – a case series of four patients

Ocular syphilis – a case series of four patients

The ghost of the great imitator: prognostic factors for poor outcome in syphilitic uveitis

Okuläre Syphilis – eine Fallserie von vier Patienten

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