2002
DOI: 10.1086/342952
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Abstract: To measure the impact of maternal syphilis on pregnancy outcome in the Mwanza Region of Tanzania, 380 previously unscreened pregnant women were recruited into a retrospective cohort at delivery and tested for syphilis. Stillbirth was observed in 18 (25%) of 73 women with high-titer active syphilis (i.e., women with a rapid plasma reagin titer > or = 1 :8 and a positive Treponema pallidum hemagglutination assay or indirect fluorescent treponemal antibody test result), compared with 3 (1%) of 233 uninfected wome… Show more

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Cited by 217 publications
(199 citation statements)
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References 27 publications
(44 reference statements)
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“…In South Africa, for example, gonorrhoea has been associated with preterm delivery. Syphilis treatment may be omitted and significantly increases the risk of both preterm birth and stillbirth [41,42]. However, there is a problem of cause-and-effect in analysing these variables as mothers who had preterm deliveries will also have a shorter time in which to accumulate antenatal visits.…”
Section: Discussionmentioning
confidence: 99%
“…In South Africa, for example, gonorrhoea has been associated with preterm delivery. Syphilis treatment may be omitted and significantly increases the risk of both preterm birth and stillbirth [41,42]. However, there is a problem of cause-and-effect in analysing these variables as mothers who had preterm deliveries will also have a shorter time in which to accumulate antenatal visits.…”
Section: Discussionmentioning
confidence: 99%
“…45 In Tanzania, T pallidum is associated with 51% of stillbirths and 24% of preterm live births. 46 Neisseria gonorrhoeae is associated with a 2-fold increase in the risk of preterm delivery, 47 whereas the risk of early preterm delivery in the presence of Ctrachomatisinfectionis4timeshigher. 48 Untreated C trachomatis infects the eyes of50%ofnewbornsatdelivery,andpneumoniawilldevelopin10%to20%ofthese infants.…”
Section: Commentmentioning
confidence: 99%
“…Untreated syphilis in pregnancy is associated with adverse clinical outcomes for the infant, including stillbirth, fetal and neonatal death, prematurity, and low-birth weight. Further, over 50% of pregnant women with untreated syphilis experience adverse pregnancy outcomes [7][8][9].…”
Section: Introductionmentioning
confidence: 99%